Rasagiline mesylate (RSM) is a hydrophilic drug with poor oral bioavailability (36%) because of hepatic first-pass metabolism. The present study focuses on delivering RSM directly to the brain through its inclusion within transferosomal in situ gel administered intranasal (IN) route. Transferosomes were formed by thin-film hydration method aid Design-Expert® software varying edge activator (EA) type absence or presence cholesterol. By desirability calculations, optimum formulation was...

Moringa oleifera is rich in various active phyto-constituents (tannins, sterols, terpenoids, flavonoids, saponins, anthraquinones, alkaloids, and vitamins) addition to different minerals its leaves seeds. Presence of these constituents responsible for the antioxidant activity ability protect against oxidative damage. Based on measurements cytotoxic activities, M. were found be more effective than plant Therefore, selected preparation silver nano-extract during present study. The...

To circumvent the low and erratic absorption of orally administrated cinnarizine (CN), intranasal lyophilized gels containing unsaturated fatty acid liposomes (ufasomes) encapsulating CN were prepared from oleic using a simple assembling strategy. The effects varying drug concentration cholesterol percentage on ufasomes size, polydispersity index entrapment efficiency investigated 3(1)4(1) full factorial design. optimized that contained 14% relative to displayed spherical morphology with...

The present study involves the preparation of cubic liquid crystalline nanoparticles (cubsomes) for liver targeting to assess potential a formulated bioactive polysaccharide isolated from hot aqueous extract Ulva fasciata as an alternative natural agent with anti-hyperlipidaemic activity. Cubosomal were prepared by disrupting gel phase and water in presence surfactant. Different lipid matrices stabilizers tested. All formulations nanosize range showed sufficient negative charge inhibit...

Bile salts containing vesicles (bilosomes) represent a portentous vesicular carrier that showed prosperous results in delivering active moieties the gastrointestinal tract (GIT). In this study, bilosomes were exploited to deliver sulfated polysaccharide-protein complexes of Enteromorpha intestinalis (EHEM) and enhance its activity against hepatocellular carcinoma as well resist harsh GIT conditions. Bilosomes prepared using sodium salt three different bile acids (cholic, deoxycholic,...

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease treated by nonsteroidal anti-inflammatory drugs (NSAIDs) including lornoxicam (LX). Nanocarriers have been used to increase the efficacy and reduce side effects of various drugs. The objective present study was compare therapeutic systemic administration lornoxicam-loaded nanomicellar formula (LX-NM) with that free LX. Materials methods: LX-loaded mixed polymeric prepared direct equilibrium technique. Two rat models were...

Tolnaftate is a thiocarbamate antifungal drug which therapeutically active against dermatophytes that cause various forms of tinea. Due to the small amount tolnaftate released from ordinary ointment bases and insufficient penetration through infected skin layers need incorporate in more suitable pharmaceutical form has evolved. A provesicular system one such can solve these problems. Once contact with skin, dilution moisture occurs rapidly transforms into vesicular one. Provesicular systems...

Defects in cardiac contractility and heart failure (HF) are common following doxorubicin (DOX) administration. Different miRs play a role HF, their targeting was suggested as promising therapy. We aimed to target miR-24, suppressor upstream of junctophilin-2 (JP-2), which is required affix the sarcoplasmic reticulum T-tubules, hence release Ca2+ excitation-contraction coupling using pachymic acid (PA) and/or losartan (LN). HF induced with DOX (3.5 mg/kg, i.p., six doses, twice weekly) 24...

Colorectal cancer (CRC) categorized as the most common type of gastrointestinal cancers affected both genders equally. Chemotherapeutic drugs became limited due to their deleterious side effects. Therefore, efficiency M. oleifera leaves extract increased by incorporating silver nanoparticles (Ag-NPs) then studied against colon induced azoxymethane (AOM) in rats.Different hematological and biochemical measurements addition specific tumor inflammatory markers were quantified. Histopathological...