A5007880092- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Micro and Nano Robotics
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Nuclear Receptors and Signaling
- Polymer Surface Interaction Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
University Hospital Münster
2022-2024
Max Planck Institute for Medical Research
2020
Lipid-based vesicles have found widespread applications in the life sciences, allowing for fundamental insights into membrane-based processes cell biology and as carrier systems drug delivery purposes. So far, mostly small unilamellar (SUVs) with diameters of ~100 nm been applied biomedical applications. Despite this progress, several systematic limitations arisen due to SUV dimensions, e.g., size total amount applicable cargo is limited. Giant (GUVs) might offer a pragmatic alternative...
Microglia, the resident immune cells of central nervous system (CNS), are derived from yolk-sac macrophages that populate developing CNS during early embryonic development. Once established, microglia population is self-maintained throughout life by local proliferation. As a scalable source microglia-like (MGLs), we here present forward programming protocol for their generation human pluripotent stem (hPSCs). The transient overexpression PU.1 and C/EBPβ in hPSCs led to homogenous mature...
Hyperexcitability is associated with neuronal dysfunction, cellular death, and consequently neurodegeneration. Redox disbalance can contribute to hyperexcitation increased reactive oxygen species (ROS) levels are observed in various neurological diseases. NOX4 an NADPH oxidase known produce ROS might have a regulating function during oxidative stress. We, therefore, aimed determine the role of on firing, hyperexcitability, hyperexcitability-induced changes neural network function. Using...
Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases. Mutations in the tau-encoding MAPT-gene lead to hereditary cases frontotemporal lobar degeneration (FTLD)-tau, which span wide phenotypic and pathological spectrum. Some these mutations, such as N279K mutation, result shift physiological 3R/4R ratio towards more aggregation prone 4R isoform. Other mutations V337M cause decrease vitro affinity tau microtubules reduced ability promote microtubule assembly....