Supplementation of dietary fiber has been proved to be an effective strategy prevent and relieve inflammatory bowel disease (IBD) through gut microbiota modulation. However, more attention paid the efficacy soluble than that insoluble (IDF). In present study, we investigated whether IDF from barley leaf (BLIDF) can inhibit inflammation via modulating intestinal in DSS-induced colitis mice. The mice were fed 1.52% BLIDF-supplemented diet for 28 days. Results demonstrated feeding BLIDF...

Akkermansia muciniphila is well known for the amelioration of inflammatory responses and restoration intestinal barrier function. The beneficial effect A. occurred through contacting Toll-like receptor 2 (TLR2) on epithelial cells by wall components. In this case, downstream mechanism pasteurized stimulating TLR2 ameliorated function worth investigating. study, we evaluated live protecting dysfunction Caco-2 induced lipopolysaccharide (LPS). We discovered that both could attenuate an...

Acrylamide (AA) is a widespread environmental and dietary-derived neurotoxin, which can induce oxidative stress associated inflammation in the brain. Anthocyanins widely occur as natural antioxidant anti-inflammatory phytochemicals. Herein, protective effects of blueberry anthocyanins extract (BAE) against AA-induced neurotoxicity were investigated rats. The rats pretreated with BAE (175 mg/kg body weight/day) by oral gavage for first 7 days, followed co-administration AA (35 next 12 days....

Adherent-invasive Escherichia coli plays an important role in the pathogenesis of inflammatory bowel disease. Blocking adhesion E. to intestinal epithelial cells appears be useful for attenuating Lycopene has been reported have anti-inflammatory and antimicrobial activities. The aim this study was test intervention effect lycopene on colitis mice investigate possible mechanism through which affects cells. (12 mg/kg BW) attenuated dextran sulfate sodium (DSS)-induced colitis, decreased...

LLM-as-a-Judge, which generates chain-of-thought (CoT) judgments, has become a widely adopted auto-evaluation method. However, its reliability is compromised by the CoT reasoning's inability to capture comprehensive and deeper details, often leading incomplete outcomes. Existing methods mainly rely on majority voting or criteria expansion, insufficient address limitation in CoT. We propose Crowd-based Comparative Evaluation, introduces additional crowd responses compare with candidate...

High hydrostatic pressure (HHP) is a non-thermal pasteurization technology for the enhancement of food products’ safety and quality. The components tomato juice can be affected by HHP processing. Little known about effects HHP-processed on gut microbiome metabolism. Here, we performed high-throughput sequencing metabolomics profiling to determine critical differences in microbiota structure metabolic profiles mice administered with juice. Tomato administration significantly increased...

The presence of pesticide residues in cowpea raises serious health concerns. In this study, a novel, sensitive, high-performance method was developed to simultaneously analyze the 35 pesticides samples from growing areas Hainan province China, November 2018 June 2021. employs modified QuEChERS sample pretreatment coupled with gas chromatography-tandem mass spectrometry. limits quantification matrix ranged 1.0 8.0 μg/kg. Twenty-seven were detected, twelve which are banned for use on legumes...

The incidence and prevalence of inflammatory bowel disease (IBD) have been increasing globally progressively in recent decades. Barley leaf (BL) is a nutritional supplement that shown to health-promoting effects on intestinal homeostasis. Our previous study demonstrated BL could significantly attenuate Citrobacter rodentium (CR)-induced colitis, but whether it exerts prophylactic or therapeutic effect remains elusive. In this study, we supplemented before during CR infestation investigate...

Abstract In this paper, a rapid and accurate method was developed for the determination of paraquat by resonance light scattering (RLS) quenching technique with common spectrofluorometer. presence paraquat, intensity (I RLS ) DNA-HCL system significantly quenched. A peak at 308 nm found. At wavelength, decrease in I proportion to concentration paraquat. The linear range calibration curve approximately 0.05–1.0 μg mL−1 detection limit (S/N = 3) 0.036 mL−1. recovery rates river water, rice,...

Inflammatory bowel disease (IBD) has become a global public health challenge. Our previous study showed that barley leaf (BL) significantly reduces Citrobacter-rodentium (CR)-induced colitis, but its mechanism remains elusive. Thus, in this study, we used non-targeted metabolomics techniques to search for potentially effective metabolites. results demonstrated dietary supplementation with BL enriched arginine and intervention ameliorated CR-induced colitis symptoms such as reduced body...

Abstract Postbiotics is a novel category of biotics that encompasses dead cells, metabolites, and derivatives from gut microbiota. These substances can exhibit their effects without containing such as in cell‐free supernatants spent media. Examples widely studied postbiotics include short‐chain fatty acids, exopolysaccharides, cell wall fragments, bacterial lysates. Evidence suggests have numerous benefits for human health, including antiaging, anti‐inflammatory properties, participation...

Sustainable herbicide-loaded nanocarriers with pH-responsiveness, good translocation and herbicidal activity were fabricated using a supramolecular assembly approach.

As a crucial step to enhance LLMs alignment with human intentions, Instruction Fine-Tuning (IFT) has high demand on dataset quality. However, existing IFT datasets often contain knowledge that is inconsistent LLMs' internal learned from the pre-training phase, which can greatly affect efficacy of IFT. To address this issue, we introduce NILE (iNternal consIstency aLignmEnt) framework, aimed at optimizing unlock capability further. operates by eliciting target pre-trained LLM's corresponding...

With the cooperation of bacteria and human body, nutrients in food are deeply digested, utilized, shared. In addition, symbiosis is formed between microorganisms hosts. Such a delicate combination makes form inherent flora body. They obtain biological basis for survival, provide necessary regulation support host terms immunity nutrition, through their functional metabolism population signals. At present, most researches focus on isolation evaluation components plants, such as plant...

Gypsum-adobe wall structure is a new type of green earth building. The feature its that the uses adobe and plaster as main materials.The erected by putting rods or stems plants between layers adobe, poured gypsum slurry into gaps bricks on surface. Then solidify come to composite structure. Finally，Gypsum interact bear stress together. This paper focuses fully describing shaking table test 1/4 scale house model Test results engineering practice show single-storey gypsum-adobe has good...

Abstract A simple, rapid, and environmentally friendly method has been established for the determination of chlorpyrifos residue in green tea by dispersive liquid-liquid microextraction(DLLME) gas chromatography-flame photometric detection (GC-FPD). Some experimental parameters that influence extraction efficiency, such as kind volume disperser solvents solvents, time, addition salt pH, were investigated. And optimal conditions obtained, quantitative analysis was carried out using external...