Visceral leishmaniasis affects people from 70 countries worldwide, mostly Indian, African and south American continent. The increasing resistance to antimonial, miltefosine frequent toxicity of amphotericin B drives an urgent need develop antileishmanial drug with excellent efficacy safety profile. In this study we have docked series febrifugine analogues (n = 8813) against trypanothione reductase in three sequential docking modes. Extra precision resulted into 108 ligands showing better...

Malaria is an endemic disease caused by the protozoan parasite Plasomodium falciparum. Febrifugine analogues are natural compound obtained from traditional Chinese herbs have shown significant antimalarial and anticancerous efficacy in experimental model. Development of resistance against existing drug has alarmed scientific innovators to find a potential molecule which can be further used countries for elimination this disease. In study, structure-based virtual screening molecular dynamics...

Abstract The cloves are grown as plantation crops in the agroclimatic conditions of Indian island Little Andaman. dried leaves, on hydrodistillation, gave 4.8% oil. GC and GC–MS analysis oil resulted identification 16 compounds. major compound was eugenol (94.4%) followed by β‐caryophyllene (2.9%). clove from Andaman found to be comparable with best produced south India terms its content. It is suggested that can an economically viable crop Andaman, Nicobar Lakshdeep islands. Copyright ©...

Introduction Open fractures remain one of the true orthopedic emergencies. Despite recent advances in surgery, management compound is still a challenge to an surgeon. are result high-speed injuries and associated with several complications such as infections, non-unions, or sometimes eventual amputation. Infection major problem open due soft tissue damage, contamination, neurovascular compromise. Presently, requires early aggressive debridement followed by limb salvage definitive...

Abstract The leaves of Indian yew Taxus wallichiana , growing in Gulmarg, Jammu and Kashmir, on hydrodistillation, gave 0.025% oil a fresh weight basis. GC GC‐MS analysis the resulted identification 62 constituents, representing 93.3% oil. main constituents identified leaf were ( E )‐2‐octen‐1‐ol (14.5%), n ‐pentacosane (8.1%), caryophyllene oxide (7.1%), 1‐octanol (6.5%), hexanoic acid (5.5%) Z )‐3‐hexenol (4.1%). Copyright © 2006 John Wiley & Sons, Ltd.

Ruchi Malika*, Pakhuri Mehtaa, Shubham Srivastavaa, Bhanwar Singh Choudharya & Manish Sharmaba Department of Pharmacy, School Chemical Sciences and Central University Rajasthan, NH-8, Bandarsindri, Kishangarh, Ajmer, Rajasthan 305817, Indiab Maharishi Markandeshwar University, Sadopur, Ambala, Haryana 134007, India

In the world of data transmission, crowded places like colleges, hospitals, railway stations and various other are facing problem wired notice boards with much complex circuitry which is problematic because one has to present in office order change information board.We suggest an authenticated system can overcome these obstacles.We need replace all this a circuit that prepared components GSM module, wireless display unit, microcontroller some important elements.Here it mention board based...

Alzheimer's disease (AD), a progressive neurodegenerative disorder is the most common cause of dementia among elderly people. To date, successful therapeutic strategy to treat AD maintaining levels acetylcholine via inhibiting acetylcholinesterase (AChE). The present study involves identification newer AChE inhibitors by dual approach e-pharmacophore and structure-based virtual screening Asinex library. Robustness docking protocol was validated enrichment calculation with ROC value .71...

Increased expression of target genes that code for proinflammatory chemical mediators results from a series intracellular cascades triggered by activation dysregulated NF-κB signaling pathway. Dysfunctional NF-kB amplifies and perpetuates autoimmune responses in inflammatory diseases, including psoriasis. This study aimed to identify therapeutically relevant inhibitors elucidate the mechanistic aspects behind inhibition. After virtual screening molecular docking, five hit opted, their...

Background Vitamin D deficiency is prevalent globally, with potential consequences for bone health and trauma outcomes. This study aimed to assess the prevalence of vitamin in orthopedic patients investigate its correlation various demographic injury-related factors. Methodology A cross-sectional investigation was undertaken at a tertiary care center. An evaluation serum 25-hydroxyvitamin D3 levels conducted on 124 individuals, aged 20 70 years, who were hospitalized injuries. Demographic...

Plants are the major source of natural flavour ingredients reported for their wide applications in food and pharmaceuticals, oral care wellness products, etc. We have investigated water-soluble fractions (WSF) basil tetraploid (O. basilicum L.) toxicity biological potential against Salmonella Typhimurium, a pathogen causing around one million cases illnesses United States every year. The WSF obtained using Clevenger-type apparatus was further divided into two equal parts, each in-vivo...

Biological mechanism attributing mutations in KCNQ2/Q3 results benign familial neonatal epilepsy (BFNE), a rare form of and thus neglected. It offers potential target for antiepileptic drug discovery. In the present work, pharmacophore-based 3D-QSAR model was generated series N-pyridyl pyrimidine benzamides possessing opening activity. The pharmacophore contains one hydrogen bond donor (D), hydrophobic (H), two aromatic rings (R). They are crucial molecular write-up detailing predicted...

Microbial biofilms have been recognized for a vital role in antibiotic resistance and chronic microbial infections 2-3 decades; still, there are no 'anti-biofilm drugs' available human applications. There is an urgent need to develop novel 'anti-biofilms' therapeutics manage biofilm-associated infectious diseases. Several reports suggested that targeting molecules involved quorum sensing or biofilm-specific transcription may inhibit biofilm formation. However, the possibility of other...

The dipeptidyl peptidase-IV (DPP-IV) family of receptors possesses a large binding cavity that imparts promiscuity for number ligand which is not common to other receptors. This feature increases the challenge using computational methods identify DPP-IV inhibitors, therefore both pharmacophore and structure-based screening seems be reliable approach. Mining novel inhibitors by integrating these in silico techniques was reported. Pharmacophore model (Model_008) obtained from structurally...