A5023557269- Neurobiology and Insect Physiology Research
- Natural product bioactivities and synthesis
- Free Radicals and Antioxidants
- Bioactive Compounds and Antitumor Agents
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive natural compounds
- Antioxidant Activity and Oxidative Stress
- Plant biochemistry and biosynthesis
- Photochromic and Fluorescence Chemistry
- Cancer therapeutics and mechanisms
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Biochemical effects in animals
- Phenothiazines and Benzothiazines Synthesis and Activities
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Drug Transport and Resistance Mechanisms
- Coenzyme Q10 studies and effects
- ATP Synthase and ATPases Research
- Sirtuins and Resveratrol in Medicine
- Phytochemical compounds biological activities
- Ginger and Zingiberaceae research
- Ginseng Biological Effects and Applications
- Insect Utilization and Effects
- Synthesis of Organic Compounds
University of Szeged
2016-2025
HUN-REN Szegedi Biológiai Kutatóközpont
2024-2025
Kaohsiung Medical University
2011-2025
Hungarian Academy of Sciences
2022
Institute of Pharmacology
2016-2021
Eötvös Loránd University
2018
European Commission
2012-2013
National Health Research Institutes
2012
Kaohsiung Medical University Chung-Ho Memorial Hospital
2012
China Medical University Hospital
2012
The leaves of the white mulberry tree (Morus alba L.) are used worldwide in traditional medicine as anti-diabetics. Various constituents leaves, such iminosugars (i.e. 1-deoxynojirimicin), flavonoids and related compounds, polysaccharides, glycopeptides ecdysteroids, have been reported to exert anti-diabetic activity, but knowledge about their contribution overall activity is limited. objective present work was determine vivo an extract (MA), examine what extent three major constituents,...
Developing green anticorrosive films is gaining great attention in science and engineering. Citrus fruit peels are mainly discarded as waste, although they can be an excellent repository of phytochemicals, that exploited mitigating agents for corrosion. Herein, we report the high anticorrosion activity a citrus extract low-carbon steel 1 M HCl solution at different temperatures. The main constituents were identified by MS NMR. Two polymethoxyflavones (PMFs), namely nobiletin...
Phytoecdysteroids like 20-hydroxyecdysone ("ecdysterone") can exert a mild, non-hormonal anabolic/adaptogenic activity in mammals, and as such, are frequently used food supplements. Spinach is well-known for its relatively low ecdysteroid content. Cyanotis arachnoidea, plant native China, among the richest sources of phytoecdysteroids, extracts this marketed tons per year amounts via internet at highly competitive prices. Here we report investigation series supplements produced Germany...
Polyphenols synthesized by plants and fungi have various pharmacological effects. The ability of polyphenols to modulate sirtuins has gained considerable interest due the role in aging, insulin sensitivity, lipid metabolism, inflammation, cancer. In particular, sirtuin 6 (SIRT6) importance regulating a variety cellular processes, including genomic stability glucose metabolism. On other hand, quercetin been demonstrated protect against several chronic diseases. this study, two derivatives,...
Multidrug resistance (MDR) is a major cause of failure cancer chemotherapy. Fifty-eight ecdysteroids, herbal analogues the insect molting hormone and their semisynthetic derivatives, were tested for activity against L5178 mouse T-cell lymphoma cells (non-MDR) subcell line transfected with pHa MDR1/A retrovirus overexpressing human ABCB1 efflux pump (MDR cell line). The compounds showed very low antiproliferative activities but modulated rhodamine 123 mediated by transporter. Roughly...
Resveratrol is a well-known natural polyphenol with plethora of pharmacological activities. As potent antioxidant, resveratrol highly oxidizable and readily reacts reactive oxygen species (ROS). Such reaction not only leads to decrease in ROS levels biological environment but may also generate wide range metabolites altered bioactivities. Inspired by this notion, the current study, our aim was take diversity-oriented chemical approach study space oxidized metabolites. Chemical oxidation...
Phenolic compounds are the main special metabolites of Cyperaceae species from phytochemical, pharmacological, and chemotaxonomical points view. The present study focused on isolation, structure determination, pharmacological investigation constituents Carex praecox. Twenty-six compounds, including lignans, stilbenes, flavonoids, megastigmanes, chromenes, phenylpropanoids, were identified methanol extract plant. Five these namely, carexines A–E, previously undescribed natural products. All...
Several antibiotic candidates are in development against Gram-positive bacterial pathogens, but their long-term utility is unclear. To investigate this issue, we studied the laboratory evolution of resistance to antibiotics that have not yet reached market. We found that, with exception compound SCH79797, generally readily evolves Staphylococcus aureus . Cross-resistance was detected between such and currently clinical use, including vancomycin, daptomycin, promising candidate teixobactin....
Globally, the incidence of obesity among adults has significantly risen since 1990, with a more than twofold rise in prevalence. Similarly, adolescents increased fourfold. Overweight constitutes significant health and social issue developed nations globally. Conventional therapies such as lifestyle modification (nutrition physical activity) have limited weight reduction. Drug therapy is often not possible or cannot be afforded due to poor patient compliance therapeutic side effects....
Rosamines represent one of the most promising groups xanthene dyes. Their excellent photophysical properties allow their widespread application. use as photosensitizers in photodynamic therapy has recently gained considerable attention. Here, we report facile, effective, microwave-assisted synthesis rosamine Pyridylbenzaldehyde derivatives were reacted with 1,3-dialkylaminophenols or 8-hydroxyjulolidine toluene without any additive. The resulting pyridyl rosamines investigated for cytotoxic...
Central nervous system (CNS) tumors are exceptionally difficult to treat, and oxidative stress-inducing radiotherapy is an important treatment modality. In this study, we examined self-assembling pro-drug nanoconjugates of naturally derived antitumor ecdysteroids, which were designed interfere with stress in brain tumor cells. Eight ecdysteroid-squalene conjugates semi-synthesized formulated into self-assembled aqueous nanosuspensions, showed excellent stability for up 16 weeks. The...
The leaves of Morus alba L. have a long history in Traditional Chinese Medicine and also became valued by the ethnopharmacology many other cultures. worldwide known antidiabetic use drug has been suggested to arise from complex combination effect various constituents. Moreover, is potential antihyperuricemic agent. Considering that type 2 diabetes hyperuricemia are vice-versa each other's important risk factors, mulberry originated phytotherapeutics might provide an excellent option for...
Cancer cells generally possess higher levels of reactive oxygen species than normal cells, and this can serve as a possible therapeutic target. In proof-of-concept study, an antioxidant-inspired drug discovery strategy was evaluated using hydroxycinnamic acid derivative. The processing oxidized mixtures p-coumaric methyl ester (pcm) revealed new antitumor lead, graviquinone. Graviquinone bypassed ABCB1-mediated resistance, induced DNA damage in lung carcinoma but exerted protective activity...
Naringenin is one of the most abundant dietary flavonoids exerting several beneficial biological activities. Synthetic modification naringenin continuous interest. During this study our aim was to synthesize a compound library oxime and ether derivatives naringenin, investigate their Two oximes five were prepared; structure has been elucidated by NMR high-resolution mass spectroscopy. The antiproliferative activity prepared compounds evaluated MTT assay against human leukemia (HL-60)...
Ginger (Zingiber officinale) is widely used as a spice and traditional medicine. Many bioactivities have been reported for its extracts the isolated compounds, including cardiovascular protective effects. Different pathways were suggested to contribute these effects, like inhibition of platelet aggregation. In this study, we synthesised fourteen 6-gingerol derivatives, eight new studied their antiplatelet, COX-1 inhibitor, antioxidant activities. silico docking selected compounds h-COX-1...
Abstract DNA damage caused during cancer treatment can rapidly activate the ataxia telangiectasia-mutated (ATM) and ATM Rad3-related (ATR)-dependent phosphorylation of Chk2 Chk1 kinases, which are hallmarks response (DDR). Pharmacologic inhibition ATR causes a synthetic lethal effect on ATM- or p53-defective cancers, suggesting that such is an effective way to improve sensitivity cancers DNA-damaging agents. Here, both natural compound protoapigenone (WYC02) its derivative WYC0209 exhibited...
P-glycoprotein (P-gp, ABCB1) over-expression, causing a multi-drug resistant (MDR) phenotype, is major problem in cancer chemotherapy that urgently requires novel approaches. Our previous studies showed certain ecdysteroid derivatives as promising chemo-sensitizers against MDR and non-MDR cell lines while also exerting mild to moderate inhibition of P-gp function. Here we report the preparation set substituted 2,3-dioxolane poststerone, known vivo metabolite 20-hydroxyecdysone (20E). In...