A5013713344- Advanced Polymer Synthesis and Characterization
- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Luminescence and Fluorescent Materials
- Polymer Surface Interaction Studies
- Click Chemistry and Applications
- Supramolecular Self-Assembly in Materials
- Polymer composites and self-healing
- Molecular Sensors and Ion Detection
- Chemical Synthesis and Analysis
- Covalent Organic Framework Applications
- Supercapacitor Materials and Fabrication
- Dendrimers and Hyperbranched Polymers
- Protein Interaction Studies and Fluorescence Analysis
- Advanced battery technologies research
- Synthesis of Indole Derivatives
- Adenosine and Purinergic Signaling
- Fluorine in Organic Chemistry
- Axial and Atropisomeric Chirality Synthesis
- Dental Research and COVID-19
- ATP Synthase and ATPases Research
- Synthesis and Catalytic Reactions
- Biosensors and Analytical Detection
- Oxidative Organic Chemistry Reactions
- Microbial Natural Products and Biosynthesis
Sichuan University
2023-2025
The University of Texas at Austin
2024-2025
University of Massachusetts Amherst
2019-2023
Zhengzhou University
2013-2017
A practical and transition-metal-free oxidative cyclization of acylhydrazones into 1,3,4-oxadiazoles has been developed by employing stoichiometric molecular iodine in the presence potassium carbonate. The conditions this reaction also work well with crude acylhydrazone substrates obtained from condensation aldehydes hydrazides. series symmetrical asymmetrical 2,5-disubstituted (aryl, alkyl, and/or vinyl) can be conveniently generated an efficient scalable fashion.
2-Amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles were synthesized via condensation of semicarbazide/thiosemicarbazide the corresponding aldehydes followed by I2-mediated oxidative C–O/C–S bond formation. This transition-metal-free sequential synthesis process is compatible with aromatic, aliphatic, cinnamic aldehydes, providing facile access to a variety diazole derivatives bearing 2-amino substituent in an efficient scalable fashion.
Self-assembly of amphiphilic polymers in aqueous solution builds up versatile carrier platforms for therapeutic delivery. Amphiphilic specifically provide "hydrophobic pockets" the encapsulation water-insoluble small-molecule drugs, along with effective strategies to control cargo release. Random and block copolymers have been separately demonstrated affect In this study, we present self-assembled structures blended random tune release lipophilic molecules. The hydrophilic–lipophilic balance...
A Pd(0)-catalyzed annulation of 2-iodoaromatic acids with ynamides is described for the efficient synthesis 3,4-disubstituted isocoumarins excellent regioselectivities.
Nitrogen-doped carbon materials have been developing rapidly over the past decade as ideal metal-free electrocatalysts in oxygen reduction reaction (ORR). Nevertheless, several challenges persist postdoping methods, including uneven distribution of active sites and low nitrogen contents, disturbing electrocatalytic performances obtained materials. In this study, we present a simple straightforward approach for situ synthesis graphyne-based catalysts via Sonogashira nitrogen-rich acetylene-...
Green fluorescent protein (GFP) chromophores are widely studied as moieties for sensing and imaging applications. Herein, we present a straightforward synthetic strategy that involves the reaction of glycine amides with 1,3-diketones to form imidazolones through an unusual molecular fragmentation recombination pathway. Mechanistic investigations, including crossover experiments, inspired competing incorporates exogenous ketones into products, yielding GFP chromophore analogues. This method...
Abstract Dynamic covalent polymer networks (DCPNs) are a class of cross‐linked polymeric materials with good self‐healing properties, processability, and recyclability. These generally possess dynamic bonds which can undergo reversible cleavage reformation under certain conditions. The cross‐linking nature the endows them needed mechanical strength as well processibility, effectively bridging gap between traditional thermosets thermoplastics. However, in many cases, relying on alone cannot...
A highly torquoselective process for simultaneous control of central and axial chirality by the annulation terminally substituted ynamides with o-quinone methides is reported. In presence AlCl3, a sequence comprising [2 + 2] cycloaddition followed 4π-electrocyclic ring opening 6π-electrocyclic closure leads to stereoselective formation diastereoisomeric 4-amino-2H-chromenes. Terminally unsubstituted undergo AlCl3-catalyzed [4 providing 2-amino-4H-chromenes.
A Sn(IV)-promoted annulation reaction of ynamides is described for the efficient synthesis 3-substituted 2-aminochromones under mild conditions. This novel method allows a concomitant construction C–C and C–O bonds between 2-methoxyaroyl chlorides by tandem Friedel–Crafts acylation/oxo-Michael addition/elimination strategy.
Mitochondria are therapeutic targets in many diseases including cancer, metabolic disorders, and neurodegenerative diseases. Therefore, strategies to deliver therapeutics of interest mitochondria important for development. As delocalized lipophilic cations (DLCs) preferentially accumulate mitochondria, DLC-conjugation has been utilized facilitate delivery systems with mitochondrial targeting capability. Here we report that upon DLC-conjugation, anionic polymers exhibit significantly improved...
Although chemical methods for the selective derivatization of amino acid (AA) side chains in peptides and proteins are available, N-terminal labeling is challenging, especially glycine, which has no chain at α-carbon position. We report here a double activation glycine's α-methylene group that allows this AA to be differentiated from other 19 AAs. A condensation reaction dibenzoylmethane with glycine results formation an imine, subsequent tautomerization followed by intramolecular...
Understanding the cellular uptake mechanism of materials is fundamental importance that would be beneficial for design with enhanced biological functions. Herein, we report interplay pharmacological and genetic approaches to minimize possible misinterpretation on mechanism. A library amphiphilic polymers was used as a model system evaluate reliability such methodological interplay. To probe polymers, utilized an orthogonal end-group labeling strategy conjugate one fluorescent molecule each...
A new multicomponent reaction involving 2-hydroxybenzaldehyde, amine, and 2-mercaptobenzaldehyde (HAM reaction) has been developed applied to polymerization controlled radical for the construction of random block copolymers. This chemistry features mild conditions, high yield, simple isolation, water as only byproduct. With advantages distinct nucleophilicity thiol hydroxyl groups, could be used stepwise labeling modifications on primary amines. The Janus chemical joint formed from this...
Optimization of metabolic regulation is a promising solution for many pathologies, including obesity, dyslipidemia, type 2 diabetes, and inflammatory liver disease. Synthetic thyroid hormone mimics-based balance in the showed promise but was hampered by low biocompatibility harmful effects on extrahepatic axis. In this work, we show that specifically directing thyromimetic to utilizing nanogel-based carrier substantially increased therapeutic efficacy diet-induced obesity mouse model,...
The dynamics of temperature-sensitive assemblies is affected by the dehydration oligoethylene glycol and thermally-promoted molecular motions. transition point sub-LCST can be modulated subtle variations in structure.
Reporting the activity of a specific viral protease remains an acute need for rapid point-of-care detection strategies that can distinguish active infection from resolved infection. In this work, we present simple colorimetric approach reporting through direct color conversion on cotton swab, which has potential to be extended detect corresponding virus. We use SARS-CoV-2 as proof-of-concept model system. 4-aminomalachite green (4-AMG) base chromophore structure design CoV2-AMG reporter, is...
Abstract Supramolecular assemblies from synthetic polymers have been widely used in materials science and biological applications. Developing convenient efficient methods to tune polymer structures architectures is important for achieving desired self‐assembly behaviors. Among various strategies, multicomponent reactions drawn significant interest due the high reaction efficiency, chemical selectivity, atom economy one‐pot manner. These features make it manipulate properties by varying...
A binding-induced supramolecular dissociation strategy is developed with the ratio of monomer and excimer fluorescence as tool for protein sensing quantification, exhibiting excellent selectivity.
Reversible addition-fragmentation chain-transfer (RAFT) polymerization is a commonly used methodology to generate synthetic polymers. The products of RAFT polymerization, i.e., polymers, have been widely employed in several biologically relevant areas, including drug delivery, biomedical imaging, and tissue engineering. In this article, we summarize display an azide group at the chain end polymer, thus presenting reactive site on polymer terminus. This platform enables click reaction between...