A5056613505- Neuroscience and Neuropharmacology Research
- RNA Interference and Gene Delivery
- Neonatal and fetal brain pathology
- Meat and Animal Product Quality
- Retinal Diseases and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Tract Infections Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Retinal Development and Disorders
- Nanoparticle-Based Drug Delivery
- RNA regulation and disease
- Bacterial Identification and Susceptibility Testing
- Neuroscience of respiration and sleep
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Aquaculture disease management and microbiota
- Calcium signaling and nucleotide metabolism
- Lipid Membrane Structure and Behavior
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Artificial Intelligence in Healthcare and Education
- Zoonotic diseases and public health
- Veterinary Medicine and Surgery
- Cancer Cells and Metastasis
University of Turin
2004-2024
Bitron (Italy)
2010
University of Chieti-Pescara
2006
Ospedale San Luigi Gonzaga
1997
Antimicrobial resistance (AMR) is defined by the entire scientific community as major threat for human health and it responsible an increase in morbidity mortality rates. The reasons behind this phenomenon are complex solution achievable only considering One Health approach, that encompasses integration implementation of health, veterinary medicine environmental status. Authors aimed to write review summarize readers three milestones One-Health, underlying most important topics which mostly...
Antimicrobial stewardship programs (ASPs) have been suggested to reduce antimicrobial resistance phenomena in veterinary medicine, as antibiotics are commonly used without microbiological confirmation. The aim of the present study is design a specific working flow for tailored treatment case canine and feline urinary tract infections (UTIs). Urine samples were collected by cystocentesis from 16 dogs 12 cats presenting acute signs UTI. therapy was decided according minimal inhibitory...
Osteosarcoma (OSA) is the most frequently diagnosed primary malignant bone tumor in humans and dogs. In both species, standard chemotherapy can be limited by multidrug resistance of neoplastic cells, which prevents intracellular accumulation cytotoxic drugs, resulting failure. this study, a lipophilic ester doxorubicin (C12DOXO) was loaded into nanoparticles (NPs) using "cold microemulsion dilution" method. The NPs were then coated with calcium phosphate (CaP) two different ways to have or...
The vanilloid receptor type 1 (TRPV1) plays a pivotal role in modulating thermal, chemical, and inflammatory pain. TRPV1s are expressed some dorsal horn (DH) neurons, but their contribution, if any, to central pain processing still remains unclear. We studied the effects of 2microM capsaicin-induced TRPV1 activation organotypically cultured substantia gelatinosa neurons from post-natal (8-12) mice. Capsaicin affected sIPSC frequency (272+/-60% control, n=14, P<0.02), not amplitude (131+/-12%...
Abstract Apoptosis can be modulated by K + and Ca 2+ inside the cell and/or in extracellular milieu. In murine organotypic cultures, membrane potential‐regulated signaling through calcineurin phosphatase has a pivotal role development maturation of cerebellar granule cells (CGCs). P8 cultures were used to analyze levels expression B lymphoma 2 (BCL2) protein, and, after particle‐mediated gene transfer CGCs, study posttranslational modifications BCL2 fused fluorescent tag response...
Canine otitis externa is frequently encountered in veterinary practice, caused by primary factors with bacteria and yeast overgrowth acting as secondary perpetuating factors. The pharmacological support includes anti-inflammatory, antimicrobials, antimycotic drugs, but therapeutic failure antimicrobial resistance are leading to alternative strategies based on phytotherapic products. This study aimed evaluate an essential oil blend (Otogen
Abstract Naturally occurring neuronal death (NOND) has been described in the postnatal cerebellum of several species, mainly affecting cerebellar granule cells (CGCs) by an apoptotic mechanism. However, little is known about cellular pathway(s) CGC apoptosis vivo . By immunocytochemistry, situ detection fragmented DNA, electron microscopy, and Western blotting, we demonstrate here existence two different molecular mechanisms rabbit cerebellum. These affect CGCs at stages their maturation...
A 3-months-old male domestic kitten was referred for repeated seizures. Analysis revealed Cryptococcus neoformans. Levetiracetam and fluconazole were administered without significant clinical improvements negativization. Hypothesizing resistance, therapy switched to amphotericin B. Seizure disappeared. Haematological controls highlighted transitory increasing of CK, BUN, ALP cholesterol. PCR two weeks after the treatment negative Nowadays cat is 5 years old, no seizures occurred since age months.
Osteosarcoma (OSA) is a bone cancer that affects both humans and animals, with dogs being particularly vulnerable. Standard therapy often limited by multidrug resistance (MDR), primarily due to the overexpression of P-glycoprotein (P-gp), which expels drugs from cells, reducing their efficacy. To overcome this challenge, drug delivery systems (DDS) P-gp modulators have been explored. However, developing DDS selectively target cells remains difficult, many current options lacking efficiency....
Myxomatous mitral valve degeneration (MMVD) is the most common acquired cardiac disease in canine species, and valvular interstitial cells (VICs) are considered main responsible for development of this pathology. The scientific interest focused on isolating characterizing these cells. aims present study were to verify a novel VICs mechanical isolation method characterize isolated using immunocytochemistry immunofluorescence, with parallel histological immunohistochemistry assays bovine...
Transient receptor potential vanilloid type 1 (TRPV1) has been investigated in humans and mammals; recent years, some researchers have focused on this fishes. The present study aimed to identify TRPV1 receptors cultures of RT-gill W1 cells the organs rainbow trout (Oncorhynchus mykiss), addition evaluating possible modulation induced by super critical fluid extract basil (Ocimum basilicum), named F1-BEO. In vitro evaluation consisted cell immunocytochemistry assays. During vivo experimental...