A5054599209- Lymphatic System and Diseases
- Pharmacological Effects of Natural Compounds
- Click Chemistry and Applications
- Biochemical and Molecular Research
- Ginseng Biological Effects and Applications
- Toxin Mechanisms and Immunotoxins
- Quinazolinone synthesis and applications
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Amino Acid Enzymes and Metabolism
- Synthesis and Characterization of Heterocyclic Compounds
- Natural Compound Pharmacology Studies
- Microbial Metabolism and Applications
- Calpain Protease Function and Regulation
- Pharmacological Effects and Toxicity Studies
- Effects of Vibration on Health
- Proteoglycans and glycosaminoglycans research
- GABA and Rice Research
- Mast cells and histamine
- Sympathectomy and Hyperhidrosis Treatments
- Synthesis and Reactivity of Heterocycles
University of Toyama
2012-2024
University of South Florida
2019-2023
Tohoku Medical and Pharmaceutical University
2011
Assiut University
2003
In the current study, potential contributions of ryanodine receptors (RyRs) to intrinsic pumping and responsiveness substance P (SP) were investigated in isolated rat mesenteric collecting lymphatic vessels. Responses SP characterized vessels absence or presence pretreatment with nifedipine block L-type Ca 2+ channels, caffeine normal release uptake from sarcoplasmic reticulum, all RyR isoforms, dantrolene more selectively RyR1 RyR3. expression localization lymphatics was also assessed by...
Abstract Brain-derived neurotrophic factor (BDNF) is a key player in synaptic plasticity, and consequently, learning memory. Because of its fundamental role numerous neurological functions the central nervous system, BDNF has utility as biomarker drug target for neurodegenerative neuropsychiatric disorders. Here, we generated screening assay to mine inducers Bdnf transcription neuronal cells, using primary cultures cortical cells prepared from transgenic mouse strain, specifically,...
Chemokine receptors CCR3 and CCR4 are preferentially expressed by Th2 cells, mast and/or eosinophils, all of which involved in the pathogenesis allergic diseases. Therefore, have long been highlighted as potent therapeutic targets for Japanese traditional herbal medicine Kampo consists multiple crude drugs/herbs, further consist numerous chemical substances. Recent studies demonstrated that such substances appear to promising sources development novel agents. Based on these findings, we...
In chronic renal failure, hypoxia of tissue is thought to be the common final pathway leading end‐stage failure. this study effects hachimijiogan, a Kampo formula, were studied with respect hypoxia‐inducible factor (HIF). Using remnant kidney rats, we hachimijiogan on function in comparison angiotensin II receptor blocker. The result showed that oral administration for seven days suppressed urinary protein excretion and 8‐OHdG, marker antioxidant activity, equally as well candesartan...
Rhynchophylline (Rhy) effectively obstructs the expansive signaling pathways of degenerative diseases, including Alzheimer disease, Parkinson epilepsy and amyotrophic lateral sclerosis, stimulates neurogenesis. Maintenance stemness cell proliferation requires sophisticated intracellular environments to achieve pluripotency via specific expression genes proteins. We examined whether Rhy promotes this regulation in bone marrow human mesenchymal stromal cells (BM-hMSCs). Results revealed (i)...
The effects of keishibukuryogan on the early stage progressive renal failure were examined in rats subjected to 5/6 nephrectomy. Keishibukuryogan, one traditional herbal formulations, was given orally at a dose 1% (w/w) and 3% chow. Administration started 1 week after nephrectomy continued for 4 weeks. At end experiment, Azan staining did not reveal any severe histological changes kidneys nephrectomized rats. On other hand, significant increases mRNA expressions transforming growth...
We evaluated the effect of kigikenchuto (KKT), a traditional Japanese formula, in modified rat pressure-loading skin ulcer model. Rats were divided into three groups, KKT extract orally administered (250 or 500 mg/kg/day for 35 days) and control. shortened duration until healing. Immunohistochemically, increased CD-31-positive vessels early phase α-smooth muscle actin-(α-SMA-) positive fibroblastic cells decreased them late wound By Western blotting, showed potential to decrease inflammatory...
In a one pot procedure, 18 compounds of 7-(substituted phenyl)-2-substituted-6,7-dihydro-4H-[1,2,4]triazolo[1,5-a] pyrimidin-5-one derivatives (16-33) have been synthesized. 3(5)-Amino-5(3)-substituted-1,2,4-triazole (7-12) were used as synthomes which cyclo-condensed by fusion with substituted methyl cinnamate esters (13-15) to afford the target (16-33). an effort develop new non-nucleoside antiviral agents, 16-33 evaluated for their anti-HIV-1 and anti-HSV-1 activities. Complete inhibition...
Abstract Background Goreisan is a traditional herbal formulation with diuretic properties tested as clinical therapeutic to alleviate lymphedema in Japan. The present study aimed determine how and its five different components affect lymphatic pump function. Methods Mesenteric collecting lymphatics were isolated from anesthetized Sprague–Dawley rats mounted on resistance‐matched glass micropipettes 37°C physiological salt solution bath for studies. Diameter was continuously measured obtain...
近年,漢方薬は様々な疾患に幅広く用いられ,その中でも五苓散は漢方医学において体内の水分代謝調節作用を持ち,生体恒常性の維持に有意に作用するとされ,臨床的にも使用頻度の高い漢方方剤のひとつである.また,多くの疾患がチャネル遺伝子の異常であることが明らかになり,正常なチャネルの局在が生理機能の恒常性維持に重要であることが分ってきた.そのひとつに腎障害があり,腎臓の集合管に存在する水チャネルであるアクアポリン(aquaporin:AQP)の発現異常により尿濃縮障害が生じることも証明されている.また,慢性腎不全モデルである5/6腎摘ラットにおいて集合管でのアクアポリン2のmRNAおよびタンパク質発現量が比較的保存されていることが報告され,これが残存尿濃縮力を支えていることが示唆されている.そこで本研究では高血糖状態を介さずに,線維化を惹起する5/6腎摘ラットを用い,五苓散の尿濃縮機能と腎組織中のアクアポリン1~3タンパク質発現量,さらに腎障害進展抑制作用に対する五苓散の影響について検討した.五苓散を投与することにより,尿中タンパク量を低下させることから,腎障害進展抑制作用を有する.また,...
Abstract Aim The purpose of this study was to explore the effects goreisan (GRS) on rats through analysis 1 H‐NMR urine samples, assess variations in metabolites affected by GRS, and gain a new metabolomic understanding Kampo medicine. Methods Male Wistar were randomly divided into two groups: control group that fed standard diet, GRS 1% diet. conducted over four‐week period. At end experiment, samples analyzed using spectroscopy evaluate metabolic changes induced administration....
In recent years, consumers’ interest in health foods has increased significantly. Among these foods, fermented are used traditionally Japanese food culture and have contributed to the maintenance of people's health. Recently, biological effects brown rice bran by Aspergillus oryzae (FBRA) been comprehensively studied, inhibitory on carcinogenesis reported. Regarding bioactive chemical constituents FBRA, involvement ferulic acid activity this study, we quantitatively investigated dependence...
In a previous paper, we analyzed the amounts of ferulic acid and its derivatives produced in fermentation brown rice bran by Aspergillus oryzae (FBRA). Ferulic are considered to be biologically active constituents FBRA these compounds increase remarkably depending on time. Another benefit is that it nutritional value food. this study, examined changes components, such as dipeptides free forms water soluble vitamins, using LC-MS analysis.
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is deeply involved in development and higher function nervous system, including learning memory. By contrast, reduction BDNF levels associated with various neurological disorders such as dementia depression. Therefore, inducers Bdnf expression might be valuable ameliorating or protecting against decline brain functions. We previously reported that, through high-throughput screening to identify Bdnf-luciferase...
A number of immunostimulant effects herbal medicines have been reported; however, the underlying mechanisms their immunostimulatory not elucidated in detail. Our previous study showed that sugar‑based nanoparticles derived from cell walls acted as component boiled Glycyrrhizae radix water extracts. Therefore, aim present was to clarify molecular by which these wall‑based functioned immunostimulants. Mouse macrophage RAW‑blue cells were stimulated and several immunological investigated. When...
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