Fermented soybean products are traditionally consumed and popular in many Asian countries the northeastern part of India. To search for potential agents interruption Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike glycoprotein 1 (S1) human angiotensin-converting enzyme (ACE2) receptor interactions, silico antiviral prospective peptides identified from proteome kinema was investigated. Soybean fermented using Bacillus licheniformis KN1G, amyloliquefaciens KN2G two different...

Background: The recent outbreak of novel coronavirus disease (COVID-19) pandemic caused by SARS-CoV-2 has posed a tremendous threat to mankind. unavailability specific drug or vaccine been the major concern date. Spike (S) glycoprotein plays most crucial role in viral infection and immunopathogenesis, hence this protein appears be an efficacious target for discovery. Objective: objective study was identify potent bioactive phytocompound that can spike human TLR4 reduce immunopathological...

Evolution of resistance among insects to action pesticides has led the discovery several insecticides (neonicotinoids and organophosphates) with new targets in insect nervous system. Present study evaluates mode inhibition acetylchlonesterase (AChE), biochemical efficacy, molecular docking 2,3-dimethylmaleic anhydride, against Periplaneta americana Sitophilus oryzae. The knockdown activity anhydride was associated vivo AChE. At KD99 dosage, showed more than 90% AChE test insects. A...

Palm wine fermentation is a complex microbial process that evolves with tapping times. The dynamics in microbiota and metabolites throughout palm days still not established, which are critical for the distinctive characteristics of taste quality, thus mastery daily quality fluctuation during tapping. We analyzed changes community structure by amplicon sequencing bacterial 16S rRNA gene fungal internal transcribed spacer (ITS) region, metabolite profile using mass spectrometry collected over...

Objective: The effect of artificial light at night (ALAN) on “transcriptome” is prominent owing to its capacity for “desynchronization” organismal physiology. Light influences the circadian rhythm. This study aims explore ALAN-induced ovarian transcriptome zebrafish desynchronization life processes. Methods: Four experimental conditions were set up female zebrafish: one normal 12-hour and dark (LD) cycle, three continuous exposures ALAN week (LLW), month (LLM), year (LLY). whole data...

Vegetation biomass production in North-East India within Indo-Burma biodiversity hotspot is luxuriant and available from April to October consider their potential for bioethanol production. Potential of six lignocellulosic (LCB) sources; namely, sugarcane bagasse (BG), cassava aerial parts (CS), ficus fruits (Ficus cunia) (FF), 'phumdi' (floating biomass) (PH), rice straw (RS) sawdust (SD) were investigated using standard techniques. Morphological chemical changes evaluated by Scanning...

Diabetes mellitus is rapidly emerging creating major health problem worldwide.Though synthetic drugs are available, due to their association with side effect, there always interest for search of herbal formulation.Quercus serrata a plant used by traditional healers Manipur, India as folk remedy treat diabetes mellitus.The objective this study bioassay guided isolation -glucosidase inhibitory compound from the leaves Quercus and check postprandial antihyperglycaemic effect isolated in...

Vibrio parahaemolyticus is a renowned enteropathogen known for infecting humans. The infection usually involves various genes which help bacterium bypass the immune system of host. Type III secretion (T3SS) an essential factor infection. present study introduces probable structure VopJ, T3SS effector V. parahaemolyticus. vopJ gene was amplified and sequenced from model generated through homology modelling showed Z score around 2.5, fits quite near in standard available databases. has only...

Graphical Abstract Light dark cycle influences the levels of Leptin and Ghrelin O-Acyl Transferase (GOAT).

Every physiological function, including feeding and energy homeostasis is vital for animal sustainability. Melatonin the neuroendocrine transducer of circadian photoperiod able to synchronize these functions. The present study demonstrates daily variation in gut melatonin mRNA expression appetite regulating hormone [leptin, nesfatin-1, orexin, ghrelin o-acetyltransferase (goat)] relation Gastrointestinal Somatic Index (Ga-SI) zebrafish ( Danio rerio ), under various lighting schedule- LD...

Abstract Citrus indica Tanaka is a wild endangered and one of the progenitor species citrus endemic to North East (NE) India, which reported in Nokrek Biosphere Reserve Garo hills Meghalaya. A orange morphologically claimed be C. was encountered Dailong forest Tamenglong district, Manipur located Indo-Burma biodiversity hotspot region. Surveys were conducted establish exact identity possible study natural habitat area. The traditional morpho-taxonomic description for identification plant...

Involvement of neuropeptides in the reproduction fish (seasonal/regular) is known. The daily rhythmicity and their possible interaction four major namely gnih, gonadotropin-inhibitory hormone; gnrh, gonadotropinreleasing kiss1/2, kisspeptin 1/2; not known to any fish. Our present study on whole brain zebrafish (Danio rerio) aimed at mRNA expression these a 12 h light/12 dark photoperiod (LD). Only kiss2 its gives but other three peptides are rhythmic. Moreover, gnih 10-fold lower than gnrh3....

The alternation of light (L) and darkness (D) cycle is the most important zeitgeber (“time giver”) circadian system. Still, feeding time also acts as a potent synchronizer teleost In fish, impact altered photoperiodic condition known, but cycles in daily rhythm fish system largely unknown. objective this work was to explore how 12 hr shift alters expression genes concerned with melatonin synthesizing enzymes zebrafish testis tissue. study, maintained under light-12 were fed at phase...