A5008815192- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gastrointestinal motility and disorders
- Cardiac Imaging and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Microscopic Colitis
- Acute Myocardial Infarction Research
- Cancer, Lipids, and Metabolism
- Sphingolipid Metabolism and Signaling
- Lipid metabolism and disorders
- Protease and Inhibitor Mechanisms
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Clinical Laboratory Practices and Quality Control
- Retinoids in leukemia and cellular processes
- SARS-CoV-2 detection and testing
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal disorders and treatments
- Lymphatic Disorders and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Congenital gastrointestinal and neural anomalies
- Estrogen and related hormone effects
- Atrial Fibrillation Management and Outcomes
- SARS-CoV-2 and COVID-19 Research
Mayo Clinic in Arizona
2016-2025
WinnMed
2015-2024
Mayo Clinic
2015-2024
Mayo Clinic in Florida
2016-2024
Universidade Federal de Alfenas
2024
Jacksonville College
2024
National Institutes of Health
2022
National Heart Lung and Blood Institute
2022
University of Minnesota Rochester
2016-2021
University of Minnesota
2021
Objective— Ceramides are sphingolipids involved with cellular signaling. Synthesis of ceramides occurs in all tissues. accumulate within tissues and the blood plasma during metabolic dysfunction, dyslipidemia, inflammation. Elevations predictive cardiovascular mortality. We sought to verify utility concentrations 4 ceramides: N-palmitoyl-sphingosine [Cer(16:0)], N-stearoyl-sphingosine [Cer(18:0)], N-nervonoyl-sphingosine [Cer(24:1)], N-lignoceroyl-sphingosine [Cer(24:0)] predicting major...
Summary Background About one‐third of patients with IBS ‐diarrhoea (irritable bowel syndrome‐D) have evidence increased bile acid synthesis or excretion. Aims To assess effects the sequestrant, colesevelam, on faecal excretion BA s, hepatic and diarrhoea in ‐D; to appraise whether individual random stool samples accurately reflect 48‐h total proportions main acids excreted study fat response colesevelam. Methods A single‐centre, unblinded, single‐dose trial 1875 mg [3 tablets (625 tablets)]...
Retinoic acid (RA) displays pronounced anticarcinogenic activities in several types of cancer. Whereas the mechanisms that underlie this activity remain incompletely understood, tumor suppression by RA is believed to emanate primarily from its ability regulate transcription multiple target genes. Here, we investigated molecular events through which inhibits growth MCF-7 mammary carcinoma cells, focusing on involvement two proteins mediate transcriptional activation RA, nuclear hormone...
Abstract The anticarcinogenic activities of retinoic acid (RA) are believed to be mediated by the nuclear RA receptor (RAR) and RA-binding protein cellular protein-II (CRABP-II). In MCF-7 mammary carcinoma cells, growth inhibition entails an early cell cycle arrest followed induction apoptosis. Here, we aimed obtain insights into initial response. We show that a 3- 5-h pulse is sufficient for inducing robust 2 4 days later, demonstrating G1-S transition triggered immediate-early RAR targets...
Approximately 25% of patients with irritable bowel syndrome-diarrhea (IBS-D) have increased total fecal bile acids (BA) and serum C4 (surrogate for BA synthesis). synthesis-related genes (KLB FGFR4) are associated colonic transit (CT) in IBS-D. Our aims were: (i) to compare phenotype pathophysiology IBS-D or normal excretion synthesis BA; (ii) explore association variations two candidate bile-acid these subgroups IBS-D.A 64 underwent on one occasion: fasting FGF19, fat excretion, CT,...
OBJECTIVES: Rifaximin relieves irritable bowel syndrome (IBS) symptoms, bloating, abdominal pain, and loose or watery stools. Our objective was to investigate digestive functions in rifaximin-treated IBS patients. METHODS: In a randomized, double-blind, placebo-controlled, parallel-group study, we compared the effects of rifaximin, 550 mg t.i.d., placebo for 14 days nonconstipated no evidence small intestinal bacterial overgrowth (SIBO). All subjects completed baseline on-treatment...
Summary Background The serum biomarkers, elevated 7αC4 (C4) and decreased FGF19, have been proposed as screening tests for bile acid diarrhoea. Aim To analyse prevalence, specificity reproducibility of fasting C4 FGF19 in identifying diarrhoea patients with irritable bowel syndrome predominant or functional (summarised IBS‐D). Methods We prospectively studied 101 IBS‐D patients; we reviewed data from 37 the prior 30 faecal acids per 48 hours. compared results normal values (C4 ≥52.5 ng/mL...
Objective: Cardiovascular disease remains a leading cause of mortality worldwide. Ceramide scores have been associated with adverse outcomes in patients established coronary artery disease. The prognostic value ceramide score has not assessed the general population. We tested hypothesis that are major cardiac events (MACE) community-based cohort average burden at enrollment. Approach and results: In prospective cohort, we performed passive follow-up using record linkage system to ascertain...
Abstract Background A valid biomarker is ‘an indicator of normal biologic or pathogenic processes, pharmacological responses to a therapeutic intervention’. There no validated for irritable bowel syndrome ( IBS ). The aim the study was assess ability three quantitative traits identify treatable processes discriminate between ‐diarrhea ‐D) patients, ‐constipation ‐C) patients and healthy volunteers HV Methods In 30 , ‐C 64 ‐D we characterized symptoms quantitated pathophysiological...
The pathobiology of irritable bowel syndrome (IBS) is multifaceted. We aimed to identify candidate genes predisposing quantitative traits in IBS. In 30 healthy volunteers, IBS-constipation, and 64 IBS-diarrhea patients, we measured symptoms, bile acid (BA) synthesis (serum 7α-hydroxy-4-cholesten-3-one FGF19), fecal BA fat, colonic transit (CT by scintigraphy), intestinal permeability (IP 2-sugar excretion). assessed associations controlling metabolism ( KLB rs17618244 FGFR4 rs351855),...
Abstract Background The accurate measurement of Low-density lipoprotein cholesterol (LDL-C) is critical in the decision to utilize new lipid-lowering therapies like PCSK9-inhibitors (PCSK9i) for high-risk cardiovascular disease patients that do not achieve sufficiently low LDL-C on statin therapy. Objective To improve estimation by developing a equation includes apolipoprotein B (apoB) as an independent variable, along with standard lipid panel test results. Methods Using β-quantification (...
Laboratory evaluation of α(1)-antitrypsin (A1AT) deficiency involves measurement circulating A1AT protein (quantitation) and characterization genetic polymorphisms (phenotyping or genotyping). This study compared adult pediatric reference ranges in patients with nondeficiency alleles examined concentrations multiple other phenotypes. phenotype quantitation were retrospectively collected on (n = 21,444) 2,469) samples that submitted for laboratory deficiency. The 95% normal populations the...
Summary Background Biomarkers in irritable bowel syndrome ( IBS ) may guide targeted therapy this multifactorial disease. It has been suggested that 75% accuracy and cost <$500 categorise biomarkers as cost‐effective. Aim To identify differences faecal bile acids, fat fasting serum C4 (7a‐hydroxy‐4‐cholesten‐3‐one) fibroblast growth factor 19 (FGF19) among patients with IBS‐D, IBS‐C healthy controls to determine accurate, cost‐effective for clinically relevant diarrhoea constipation....