A5001464008- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Fungal Infections and Studies
- Cytomegalovirus and herpesvirus research
- Bacterial Identification and Susceptibility Testing
- Antifungal resistance and susceptibility
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- Cervical Cancer and HPV Research
- Biosensors and Analytical Detection
- Reproductive tract infections research
- Infection Control and Ventilation
- Infectious Encephalopathies and Encephalitis
- Streptococcal Infections and Treatments
- Viral Infections and Immunology Research
- Vector-borne infectious diseases
- Virus-based gene therapy research
- Long-Term Effects of COVID-19
- Autoimmune Neurological Disorders and Treatments
- Syphilis Diagnosis and Treatment
- Virology and Viral Diseases
Mayo Clinic
2015-2024
Mayo Clinic in Arizona
2008-2024
Oregon Medical Research Center
2022
Lindsay Unified School District
2022
University of Pittsburgh
2022
New York Proton Center
2022
Communities In Schools of Orange County
2022
Manhattan Institute for Policy Research
2022
University of Minnesota Rochester
2020
WinnMed
2006-2020
The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between physician/advanced practice provider and microbiologists who provide enormous value to healthcare team. This document, developed by experts adult pediatric clinical medicine, provides information on which tests are valuable contexts, that add little or no diagnostic decisions. document presents system-based approach rather than specimen-based approach,...
The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between physician/advanced practice provider and microbiologists who provide enormous value to healthcare team. This document, developed by experts adult pediatric clinical medicine, provides information on which tests are valuable contexts, that add little or no diagnostic decisions. document presents system-based approach rather than specimen-based approach,...
ABSTRACT The detection of pathogens associated with gastrointestinal disease may be important in certain patient populations, such as immunocompromised hosts, the critically ill, or individuals prolonged that is refractory to treatment. In this study, we evaluated two commercially available multiplex panels (the FilmArray [GI] panel [BioFire Diagnostics, Salt Lake City, UT] and Luminex xTag pathogen [GPP] [Luminex Corporation, Toronto, Canada]) using Cary-Blair stool samples ( n = 500)...
Ehrlichiosis is a clinically important, emerging zoonosis. Only Ehrlichia chaffeensis and E. ewingii have been thought to cause ehrlichiosis in humans the United States. Patients with suspected routinely undergo testing ensure proper diagnosis ascertain cause.
The coronavirus disease (COVID-19) pandemic has placed the clinical laboratory and testing for SARS-CoV-2 front center in worldwide discussion of how to end outbreak. Clinical laboratories have responded by developing, validating, implementing a variety molecular serologic assays test infection. This played an essential role identifying cases, informing isolation decisions, helping curb spread disease. However, as demand COVID-19 increased, professionals faced growing list challenges,...
Several vaccines are now available under emergency use authorization in the United States and have demonstrated efficacy against symptomatic COVID-19. Vaccine impact on asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is largely unknown.
Abstract The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between physician and microbiologists who provide enormous value to healthcare team. This document, developed by experts both adult pediatric clinical medicine, provides information on which tests are valuable contexts, that add little or no diagnostic decisions. Sections divided into anatomic systems, including Bloodstream Infections Cardiovascular...
Rapid and accurate laboratory tests are important for the timely diagnosis treatment of central nervous system infections. The FilmArray meningitis/encephalitis (ME) panel (BioFire Diagnostics, Salt Lake City, UT) is an FDA-cleared, multiplex molecular that allows detection 14 pathogens (bacterial [n = 6], viral 7], fungal 1] pathogens) from cerebrospinal fluid (CSF). In this study, we evaluated performance characteristics ME using clinical, residual CSF samples (n 291) tested positive by a...
ABSTRACT Blastomyces dermatitidis and Histoplasma capsulatum are dimorphic fungi that often cause self-limited respiratory infections. However, they may also severe disseminated disease, depending on the level of exposure to organism host immune status. In addition, patients with infections caused by these have very similar clinical presentations. Although microbiologic culture is a standard method for detecting pathogens, their recovery require days weeks, manipulation cultures presents...
To report the frequency of coexisting herpes viruses (herpes simplex virus 1 [HSV-1] or HSV-2, varicella zoster virus, Epstein-Barr [EBV], cytomegalovirus, human 6 [HHV-6]) and autoantibodies in patients with encephalitis autoimmune) clinical laboratory service.Three groups were evaluated for antibodies: group 1-patients whose CSF was positive a by real-time PCR over period months; 2-patients an autoimmune encephalitis-associated antibody 5 years (e.g., NMDA receptor [NMDA-R] antibody), same...
Autoimmune encephalitis (AE) cases after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported, but the frequency is unknown. We aimed to determine and diagnostic features of disease 2019 (COVID-19)-related AE.Residual sera from 556 consecutive Mayo Clinic Rochester patients (laboratory cohort) who underwent autoimmune encephalopathy neural immunoglobulin G (IgG) evaluation were tested for total antibodies against SARS-CoV-2 spike glycoprotein using a Food...
Importance Little is known about the burden and outcomes of respiratory syncytial virus (RSV)–positive acute infection (ARI) in community-dwelling older adults. Objective To assess incidence RSV-positive ARI before during COVID-19 pandemic, to for Design, Setting, Participants This was a community-based cohort study adults residing southeast Minnesota that followed up with 2325 aged 50 years or 2 RSV seasons (2019-2021) ARI. The assessed at 4 weeks, 6 7 months, 12 13 months after Exposure...
Coccidioides spp. are dimorphic fungal pathogens endemic to the semiarid regions of North, Central, and South America. Currently, direct smear culture most common means identifying While these methods offer relatively sensitive specific detecting spp., growth in may take up 3 weeks, potentially delaying diagnosis initiation appropriate antifungal therapy. In addition, organism represents a significant safety risk laboratory personnel. The need for rapid safe diagnosing coccidioidomycosis...
ABSTRACT The diagnosis of syphilis is challenging and often relies on serologic tests to detect treponemal or nontreponemal antibodies. Recently, the Centers for Disease Control Prevention Association Public Health Laboratories proposed an update serology testing algorithm, in which serum samples are first tested using a treponema-specific test positive analyzed with assay. goal this study was compare performance seven assays (BioPlex 2200 IgG [Bio-Rad, Hercules, CA], fluorescent antibody...
ABSTRACT We describe the first direct comparison of reverse and traditional syphilis screening algorithms in a population with low prevalence syphilis. Among 1,000 patients tested, results for 6 were falsely reactive by screening, compared to none testing. However, identified 2 possible latent that not detected rapid plasma reagin (RPR).
ABSTRACT We compared an FDA-cleared rapid (<20 min) PCR assay (Cobas Liat; Roche Diagnostics) to our routine influenza A and B real-time (Simplexa Flu A/B & RSV Direct; Focus using respiratory swabs ( n = 197). The Cobas Liat assays demonstrated sensitivities of 99.2% (123/124) 100% (23/23), respectively, while showing a specificity for each target.