A5009455702- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Alzheimer's disease research and treatments
- Sexual function and dysfunction studies
- Sexuality, Behavior, and Technology
- Neuroscience and Neuropharmacology Research
- Cancer-related gene regulation
- RNA Research and Splicing
- Traditional Chinese Medicine Analysis
- Mitochondrial Function and Pathology
- 14-3-3 protein interactions
- Physical Activity and Health
- Sports injuries and prevention
- Metabolomics and Mass Spectrometry Studies
- Nuclear Receptors and Signaling
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Prion Diseases and Protein Misfolding
- Analytical Chemistry and Chromatography
- Lung Cancer Research Studies
- Sport Psychology and Performance
- Amino Acid Enzymes and Metabolism
- Evolutionary Psychology and Human Behavior
- MicroRNA in disease regulation
- Circular RNAs in diseases
Wuhan University of Science and Technology
2024
University of British Columbia
2020-2023
Xuzhou Medical College
2023
University of Kentucky
2012-2020
Yichang Central People's Hospital
2014
China Three Gorges University
2014
Huazhong University of Science and Technology
2004-2008
Hyperphosphorylated tau is the major protein subunit of neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. It not understood, however, why tangle-containing neurons seen AD brains do die apoptosis but rather degeneration even though they are constantly awash a proapoptotic environment. Here, we show that cells overexpressing exhibit marked resistance to induced by various apoptotic stimuli, which also causes correlated hyperphosphorylation glycogen synthase kinase 3...
Microtubule-associated protein tau is abnormally hyperphosphorylated in Alzheimer's disease (AD) and other tauopathies believed to lead neurodegeneration this family of diseases. Here we show that infusion forskolin, a specific cAMP-dependent kinase A (PKA) activator, into the lateral ventricle brain adult rats induced activation PKA by severalfold concurrently enhanced phosphorylation at Ser-214, Ser-198, Ser-199, or Ser-202 (Tau-1 site) Ser-396 Ser-404 (PHF-1 site), which are among major...
Abstract The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq RNA Bind-N-Seq technologies, show binds ∼4,900 RNAs enriched for GGUA motifs adult mouse brains. exhibit similar binding patterns introns, are 3′ untranslated regions alter genes distinct from TDP-43. However, unlike has a minimal role alternative splicing. In human neural progenitors, affect turnover...
The C-terminal nuclear localization sequence of FUsed in Sarcoma (FUS-NLS) is critical for its import mediated by transportin (Trn1). Familial amyotrophic lateral sclerosis (ALS) related mutations are clustered FUS-NLS. We report here the structural, biochemical and cell biological characterization FUS-NLS clinical implications. crystal structure FUS-NLS/Trn1 complex shows extensive contacts between two proteins a unique α-helical binding affinity Trn1 (wide-type 12 ALS-associated mutants)...
Cervical cancer ranks fourth in women terms of incidence and mortality. The RNA-binding protein YTH N6-methyladenosine F2 (YTHDF2) contributes to progression by incompletely understood mechanisms. We show how YTHDF2 controls the fate cervical cells whether could be a valid target for therapy cancer. Sphere formation alkaline phosphatase staining assays were performed evaluate tumor stemness following knockdown. Apoptosis was detected flow cytometry TUNEL assay. compounds 4PBA SP600125 used...
Mutations in Fused sarcoma (FUS) gene cause a subset of familial amyotrophic lateral sclerosis (ALS), fatal motor neuron degenerative disease. Wild-type FUS is largely localized the nucleus, but mutant accumulates cytoplasm and forms inclusions. It unclear whether depletion from nucleus or inclusions triggers degeneration. In this study, we revealed that nuclear cytoplasmic proteins form distinct local distribution patterns. The oligomers appears granular under confocal microscope. contrast,...
FUsed in sarcoma (FUS) is a multifunctional DNA/RNA-binding protein that possesses diverse roles, such as RNA splicing, transport, DNA repair, translation, and transcription. The network of enzymes processes regulated by FUS far from being fully described. In this study, we have focused on the mechanisms FUS-regulated manganese superoxide dismutase (MnSOD) gene transcription.Here demonstrate component transcription complex regulates expression MnSOD. Overexpression increased MnSOD...
1. Chlorogenic acids (CGAs), one kind of major bioactive constituents isolated from Flos Lonicera Japonica, possess many biological activities, such as antibacterial, antioxidant and antiviral activities. In this study, we established an efficient strategy using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) to profile the in vivo metabolic fate CGAs rat urine plasma.2. The extract Japonica was orally administrated...
Abstract Fused in sarcoma (FUS) is a ubiquitously expressed RNA/DNA‐binding protein that plays different roles the cell. FUS pathology has been reported neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations have also linked to subset of familial ALS. mainly localized nucleus although it shuttles between cytoplasm. ALS‐linked mutations cause accumulation cytoplasm where forms stress granule‐like inclusions. The protein‐ RNA‐containing...
Asexuality has garnered much attention, and empirical data support its classification as a sexual orientation. is defined lack of attraction to others, with approximately 1% the population falling in this category. As theoretical models situate attention central component response, current study examined attentional processing erotic stimuli asexuals heterosexuals. We hypothesized that heterosexual participants would have initial controlled visual patterns favoring images over non-erotic...
Objectives We examined changes in frequency of sexual behaviors, dyadic desire, relationship satisfaction, and COVID-19 stress Canadians across the pandemic, considering partner status.Methods Participants completed online questionnaires.Results with live-in partners single participants decreased behaviors. In August–September 2020, engaged more behaviors than participants. November 2021, all partnered Decreases were observed.Conclusions Findings suggest that despite decreases stress, there...
Abstract Background Colorectal cancer (CRC) is one of the most common types affecting both men and women. MicroRNA-492 (miR-492) plays an important role in development various malignant tumours; however, its specific related mechanisms CRC remain unclear. Hence, we aimed to explore relationship between miR-492 prognosis patients involved CRC. Methods The GSE29622 dataset was downloaded from Gene Expression Omnibus database analyse expression level overall survival with Forty-four pairs...