A5043395309- Cardiac Valve Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Electrospun Nanofibers in Biomedical Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Congenital heart defects research
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Parathyroid Disorders and Treatments
- Cardiac and Coronary Surgery Techniques
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Structural Anomalies and Repair
- Neuroendocrine Tumor Research Advances
- Photoreceptor and optogenetics research
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Congenital Heart Disease Studies
- Angiogenesis and VEGF in Cancer
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
MedStar Washington Hospital Center
2023-2024
UNSW Sydney
2024
MedStar Heart & Vascular Institute
2022-2023
Cleveland Clinic
2019-2022
Penn State Milton S. Hershey Medical Center
2020
Akron General Medical Center
2020
Northeast Ohio Medical University
2020
Stanford University
2013-2019
Stanford Medicine
2019
Palo Alto Veterans Institute for Research
2019
Solar-powered heart? Harnessing light to create myocardial renewable energy.
Exogenously delivered chemokines have enabled neovasculogenic myocardial repair in models of ischemic cardiomyopathy; however, these molecules short half-lives vivo. In this study, we hypothesized that the sustained delivery a synthetic analog stromal cell-derived factor 1-α (engineered [ESA]) induces continuous homing endothelial progenitor cells and improves left ventricular function rat model infarction.Our previously designed ESA peptide was synthesized by addition fluorophore tag for...
Background: The conventional method of implanting balloon-expandable SAPIEN-3 (S3) valve results in a final 70:30 or 80:20 ratio the aorta:left ventricular outflow tract with published rates permanent pacemaker around 10%. We sought to evaluate whether higher implantation S3 reduces conduction abnormalities including need for pacemaker. Methods: included consecutive patients who underwent transfemoral transcatheter aortic replacement using between April 2015 and December 2018 compared...
Background— Neuregulin-1β (NRG) is a member of the epidermal growth factor family possessing critical role in cardiomyocyte development and proliferation. Systemic administration NRG demonstrated efficacy cardiomyopathy animal models, leading to clinical trials using daily infusions. This approach hindered by requiring infusions off-target exposure. Therefore, this study aimed encapsulate hydrogel be directly delivered myocardium, accomplishing sustained localized delivery. Methods Results—...
Background— Endothelial progenitor cells (EPCs) possess robust therapeutic angiogenic potential, yet may be limited in the capacity to develop into fully mature vasculature. This problem might exacerbated by absence of a neovascular foundation, namely pericytes, with simple EPC injection. We hypothesized that coculturing EPCs smooth muscle (SMCs), components surrounding vascular wall, cell sheet will mimic native spatial orientation and interaction between SMCs create supratherapeutic...
After myocardial infarction, there is an inadequate blood supply to the myocardium, and surrounding borderzone becomes hypocontractile.To develop a clinically translatable therapy, we hypothesized that in preclinical ovine model of modified endothelial progenitor stem cell chemokine, engineered stromal cell-derived factor 1α analog (ESA), would induce chemotaxis, limit adverse ventricular remodeling, preserve contractility.Thirty-six adult male Dorset sheep underwent permanent ligation left...
Background Numerous quality metrics for heart failure (HF) care now exist based on process and outcome. What remains unclear, however, is if the correct are being emphasized. To determine validity of certain measures, we compared correlations between measures reliability over time. Measures assessed include guideline-recommended β-blocker (BB), any BB, angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker, mineralocorticoid antagonist, hydralazine/isosorbide dinitrate...
There exists a substantial body of work describing cardiac support devices to mechanically the left ventricle (LV); however, these lack biological effects. To remedy this, we implemented cell sheet engineering approach utilizing chondrocytes, which in their natural environment produce relatively elastic extracellular matrix (ECM) for cushioning effect. Therefore, hypothesized that chondrocyte applied infarcted and borderzone myocardium will biologically enhance ventricular ECM increase...
Coronary obstruction during transcatheter aortic valve replacement (TAVR) is a rare, yet life-threatening, complication. The routine use of left main (LM) protection with or without stent placement in high-risk patients remains controversial. aim this study was to evaluate the outcomes LM TAVR and identify anatomic factors associated need for placement.
Abstract Background Baseline conduction abnormalities are known risk factors for permanent pacemaker (PPM) implantation after transcatheter aortic valve replacement (TAVR). We sought to determine the impact of baseline right bundle branch block (RBBB), left (LBBB), anterior hemiblock (LAHB), first‐degree atrioventricular (AVB) and atrial fibrillation/flutter (AF) on TAVR outcomes. Methods Consecutive patients who underwent transfemoral with SAPIEN‐3 (S3) were included. excluded prior PPM,...
Ischemic heart disease is a major health problem worldwide, and current therapies fail to address microrevascularization. Previously, our group demonstrated that the sustained release of novel engineered stromal cell-derived factor 1-a analogue (ESA) limits infarct spreading, collagen deposition, improves cardiac function by promoting angiogenesis in region surrounding infarct, restores tensile properties infarcted myocardium. In this study, using well-established rat model ischemic...