A5038842664- Respiratory viral infections research
- Global Maternal and Child Health
- Infection Control and Ventilation
- Organ Transplantation Techniques and Outcomes
- Vector-borne infectious diseases
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Infection Control in Healthcare
- Viral Infections and Vectors
- Child Nutrition and Water Access
- Respiratory Support and Mechanisms
- Renal Transplantation Outcomes and Treatments
- Influenza Virus Research Studies
- Emergency and Acute Care Studies
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Neonatal and Maternal Infections
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Herpesvirus Infections and Treatments
- Data-Driven Disease Surveillance
- Vaccine Coverage and Hesitancy
Children's Hospital of Philadelphia
2016-2024
University of Pennsylvania
2018-2024
Children's Health Ireland at Crumlin
2024
Pediatrics and Genetics
2021
Office of Infectious Diseases
2016
Tufts University
2015
Baystate Medical Center
2014
The severe acute respiratory coronavirus-2 (SARS-CoV-2) is the cause of global outbreak COVID-19. Evidence suggests that virus evolving to allow efficient spread through human population, including vaccinated individuals. Here, we report a study viral variants from surveillance Delaware Valley, city Philadelphia, and infecting subjects. We sequenced analyzed complete genomes 2621 samples March 2020 September 2021 compared them genome sequences 159 vaccine breakthroughs. In early spring 2020,...
Abstract Background: Implementing antimicrobial stewardship programs (ASPs) can be challenging due to prescriber resistance. Although barriers implementing new ASPs have been identified, little is known about how prescribers perceive established programs. This information critical promoting the sustainability of ASPs. Objective: To identify an pediatric inpatient ASP that primarily utilizes prior authorization. Methods: We conducted a cross-sectional survey administered from February through...
Influenza vaccination of healthcare workers (HCWs) has been recommended for more than 30 years. In 2009, HCWs were designated as a priority group by the Centers Disease Control and Prevention. Current HCW rates are 78% across all settings reach approximately 92% among those employed in hospital settings. Over last decade, it become clear that mandatory vaccine policies result maximal immunization.In this observational 10-year study, we describe implementation influenza policy dedicated...
Attention-deficit hyperactivity disorder (ADHD) is the most common neurobehavioral of childhood, affecting 5-8% children. It has been observed that these children have poor sedation experiences; however, to date there minimal research on procedural in this population.To examine whether with ADHD required larger doses propofol for magnetic resonance imaging (MRI) sedation.The hospital's administrative billing database was used identify all codes MRI brain scans (with and without contrast)...
Surgical site infections (SSIs) are a common complication in liver transplant (LT) recipients. Lack of pediatric prophylaxis guidelines results variation preventative antibiotic regimens.
Objectives A disproportionate number of neonatal deaths occur in low/middle-income countries, with sepsis a leading contributor mortality. In this study, we investigate risk factors for mortality cohort high-risk hospitalised neonates Botswana. Independent predictors infants experiencing either or non-sepsis-related death are described. Methods This is prospective observational study enrolled from July to October 2018 at the unit (NNU) Princess Marina Hospital (PMH) Gaborone, Data on...
Data on the potential benefits and risks of induction therapy in pediatric liver transplantation (LT) are limited. This was a retrospective cohort study 2748 LT recipients at 26 children's hospitals between January 1, 2006 to May 31, 2017 using data from health information system linked United Network for Organ Sharing database. The regimen obtained day-by-day pharmacy resource utilization. Cox proportional hazards evaluated association (none/corticosteroid-only, nondepleting, depleting)...
An 8-year old girl presented to our facility with a 10-day history of fever, fatigue, abdominal pain and refusal walk. She recently travelled from her native Algeria where she first developed symptoms. On evaluation, was ill-appearing, febrile tachycardic hepatosplenomegaly lymphadenopathy noted on examination. A strong musty odor also the child. Laboratory evaluation revealed pancytopenia, hyponatremia, an elevated AST, ALT, LDH. Malaria testing negative, as PPD. further questioning, family...
Transplant center performance and practice variation for pediatric post-liver transplantation (LT) outcomes other than survival are understudied. This was a retrospective cohort study of LT recipients who received transplants between January 1, 2006, May 31, 2017, using United Network Organ Sharing (UNOS) data that were merged with the Pediatric Health Information System database. Center effects acute rejection rate at 1 year after (AR1) UNOS coding biliary complication (BC1) inpatient...
Abstract The severe acute respiratory coronavirus-2 (SARS-CoV-2) is the cause of global outbreak COVID-19. Evidence suggests that virus evolving to allow efficient spread through human population, including vaccinated individuals. Here we report a study viral variants from surveillance Delaware Valley, city Philadelphia, and infecting subjects. We sequenced analyzed complete genomes 2621 samples March 2020 September 2021 compared them genome sequences 159 vaccine breakthroughs. In early...
Objectives: Data on triage practices of children admitted to Princess Marina Hospital in Gaborone, Botswana is limited. The inpatient triage, assessment, and treatment score was developed for low resource settings predict mortality children. We assess its performance among their demographic, clinical, risk factors death. Methods: This a secondary data analysis prospective cohort study comprising 299 ages 1 month 13 years June September 2018. Descriptive statistics, bivariate analysis,...
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Influenza is a significant cause of childhood morbidity and death; it contributes to up 16% hospitalizations for respiratory illnesses worldwide. Novel rapid viral diagnostic tests, including molecular have the potential significantly affect both time diagnosis selection optimal anti-infective therapy. However, little known about current treatment algorithms used in US hospitals. In this study, hospitalized children United States, we aimed define approaches influenza explore reasons their...
Abstract Intravenous immunoglobulin (IVIg) therapy is increasingly used in the pediatric population, particular among children with immune‐compromising conditions. Pooled products are routinely tested for hepatitis B surface antigen (HBsAg) and nucleic acid; however, screening core antibody (anti‐HBc) not commonly performed. Thus, administration of IVIg containing anti‐HBc to conditions may complicate interpretation serologic testing that a positive test represent passive transfer from or...
Abstract Background The Centers for Disease Control and Prevention (CDC) recommends upper respiratory tract (URT) polymerase chain reaction (PCR) testing as the initial diagnostic test Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Lower (LRT) patients requiring mechanical ventilation is also recommended. goal of this study was to evaluate concordance between paired URT LRT specimens in children undergoing pre-admission/procedure screening or testing. We hypothesized that...
Over the past decade, concerning trends in antimicrobial resistance have emerged Southern Africa. Given a paucity of pediatric data, our objectives were to (1) describe antibiotic utilization at national referral center Africa and (2) assess proportion patients receiving antibiotics appropriately. In addition, risk factors for inappropriate use explored.We performed prospective cohort study on medical surgical aged below 13 years admitted country's tertiary care hospital Gaborone, Botswana....
Abstract Early in the coronavirus disease 2019 (COVID-19) pandemic, CDC recommended collection of a lower respiratory tract (LRT) specimen for severe acute virus 2 (SARS-CoV-2) testing addition to routinely upper (URT) mechanically ventilated patients. Significant operational challenges were noted at our institution using this approach. In report, we describe experience with routine paired URT and LRT sample testing. Our results revealed high concordance between sources, that all children...
OBJECTIVES Empirical broad-spectrum antibiotics are routinely administered for short durations to children with suspected bacteremia while awaiting blood culture results. Our aim this study was estimate the proportion of antibiotic use accounted by these “rule-outs.” METHODS The Pediatric Health Information System used identify aged 3 months 20 years hospitalized between July 2016 and June 2017 who received bacteremia. Using an electronic definition a rule-out, we estimated all days therapy...
• While common in chronic HIV, acute pancreatitis has rarely presented as primary HIV infection. We describe the second ever reported case of an adolescent who with masquerading Acute or infection is time from initial until complete seroconversion. Given high levels viremia and positive correlation transmission, such patients are highly infectious.
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Rotavirus (RV) was a common healthcare-associated infection prior to the introduction of RV vaccine. Following widespread vaccination, rotavirus cases are rare. We describe an investigation cluster infections in pediatric hospital which uncommon genotype not typically circulating United States detected.