A5107006105- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Hepatitis B Virus Studies
- Plant Pathogens and Resistance
- Food Drying and Modeling
- Antimicrobial Peptides and Activities
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Phytochemicals and Antioxidant Activities
- SARS-CoV-2 and COVID-19 Research
- Phytochemical compounds biological activities
- Yeasts and Rust Fungi Studies
- Viral Infections and Outbreaks Research
- Synthesis and biological activity
- Postharvest Quality and Shelf Life Management
- Insect Resistance and Genetics
- Hepatitis C virus research
- Immune Response and Inflammation
- Fungal Infections and Studies
- Animal Virus Infections Studies
- Multicomponent Synthesis of Heterocycles
- Microbial Natural Products and Biosynthesis
Shandong University
2022-2024
Thomas Jefferson University Hospital
2021
Shenyang Agricultural University
2021
McMaster University
2015
University of Louisville
2005-2006
Tokyo Medical and Dental University
2005-2006
Kyoto University
2005-2006
Augusta University
2005-2006
St. Marianna University School of Medicine
2005-2006
Previously, we have identified a highly potent CXCR4 antagonist 2 [cyclo(-d-Tyr1-Arg2-Arg3-Nal4-Gly5-)] and its Arg2 epimer 3 [cyclo(-d-Tyr1-d-Arg2-Arg3-Nal4-Gly5-)] by the screening of cyclic pentapeptide libraries that were designed based on structure−activity relationship studies 14-residue peptidic 1. In present study, new series analogues synthesized to evaluate influences peptide side-chain backbone modification bioactivities. Based Ala-scanning in which each residue was replaced with...
A highly potent CXCR4 antagonist, compound 2, was previously found by using two orthogonal cyclic pentapeptide libraries involving conformation-based and sequence-based based on the pharmacophore of a 14-mer peptidic 1. Herein, tetrapeptides derived from replacements dipeptide unit (Nal-Gly) with γ-amino acid pseudopeptides cyclized disulfide olefin bridges were synthesized to find novel scaffold structures different that pentapeptides. These compounds contain reduced number peptide bonds...
Structure–activity relationship studies on CXCR4 antagonists, which were previously found by using cyclic pentapeptide libraries, performed to optimize side-chain functional groups, involving conformationally constrained analogues. In addition, a new lead of pentapeptides with the introduction novel pharmacophore was developed.
A linear type of several low molecular weight CXCR4 antagonists were developed based on T140 analogs, which previously found to be strong that block X4-HIV-1 entry and have inhibitory activities against cancer metastasis/progression rheumatoid arthritis.
Abstract The severe acute respiratory coronavirus-2 (SARS-CoV-2) is the cause of global outbreak COVID-19. Evidence suggests that virus evolving to allow efficient spread through human population, including vaccinated individuals. Here we report a study viral variants from surveillance Delaware Valley, city Philadelphia, and infecting subjects. We sequenced analyzed complete genomes 2621 samples March 2020 September 2021 compared them genome sequences 159 vaccine breakthroughs. In early...
Chronic hepatitis B virus (HBV) infection is a global health problem that substantially increases the risk of developing liver disease. The development novel strategy to induce anti-HB seroconversion and achieve long-lasting immune response against chronic HBV remains challenging. Here, we found affected signaling pathway involved in STING-mediated induction host responses dendritic cells (DCs) then generated lymph node-targeted nanovaccine co-delivered surface antigen (HBsAg) cyclic...