A5057071203- CAR-T cell therapy research
- Genetic Mapping and Diversity in Plants and Animals
- Hepatitis B Virus Studies
- Genetic Associations and Epidemiology
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Microbial Natural Products and Biosynthesis
- Blind Source Separation Techniques
- Nanowire Synthesis and Applications
- Sparse and Compressive Sensing Techniques
- Functional Brain Connectivity Studies
- Gene expression and cancer classification
- Immune Cell Function and Interaction
- Viral Infectious Diseases and Gene Expression in Insects
- Genomic variations and chromosomal abnormalities
- Phytochemical compounds biological activities
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- MRI in cancer diagnosis
- Ecology and Vegetation Dynamics Studies
- Advanced Graph Neural Networks
- Graph Theory and Algorithms
University of Chicago
2020-2025
North Carolina State University
2022-2024
Shandong University
2021-2024
The University of Texas Southwestern Medical Center
2023
Washington University in St. Louis
2019-2022
Metabolic reprogramming of tumor cells is an emerging hallmark cancer. Among all the changes in cancer metabolism, increased glucose uptake and accumulation lactate under normoxic conditions (the "Warburg effect") a common feature cells. In this study, we develop lactate-responsive drug delivery platform by targeting Warburg effect. We design test gold/mesoporous silica Janus nanoparticle system as gated carrier, which gold particles are functionalized with oxidase capped α-cyclodextrin...
SUMMARY Chimeric antigen receptor (CAR) T-cell therapy has expanded therapeutic options for patients with diffuse large B-cell lymphoma (DLBCL). However, progress in improving clinical outcomes been limited by an incomplete understanding of CAR differentiation patients. To comprehensively investigate vivo, we performed single-cell, multi-modal, and longitudinal analyses CD28-costimulated T cells from infusion product peripheral blood (day 8-28) DLBCL who were successfully treated...
Abstract Background: Chimeric antigen receptor (CAR) T-cell therapy has expanded therapeutic options for patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). However, progress in improving clinical outcomes been limited by an incomplete understanding of CAR differentiation patients. Methods: To comprehensively investigate vivo, we performed single-cell, multi-modal, and longitudinal analyses CD28-costimulated T cells from infusion product peripheral blood (day 8-28)...
Piperazate (Piz) is a nonproteinogenic amino acid noted for its unusual N–N bond motif. Piz proline mimic that imparts conformational rigidity to peptides. Consequently, piperazyl molecules are often bioactive and desirable therapeutic exploration. The in vitro characterization of Kutzneria enzymes KtzI KtzT recently led biosynthetic pathway Piz. However, anabolism vivo has remained completely uncharacterized. Herein, we describe the systematic interrogation actinobacterial metabolism using...
Purpose: Alum adjuvant in HBV prophylactic vaccines is poor inducing cellular immunity with the inhibition of IL-12 secretion, and approximately 5– 10% immunised individuals fail to clear upon infection. plasmids (pIL-12) as adjuvants enhance significant humoral immune response vaccines. However, finding a novel delivery system protect pIL-12 from enzymatic degradation achieve efficient remains major challenge. Methods: We prepared chitosan nanovaccine-loaded expression plasmid (termed...
Rare actinomycetes represent an underexploited source of new bioactive compounds. Here, we report the use a targeted metabologenomic approach to identify piperazyl compounds in rare actinomycete Lentzea flaviverrucosa DSM 44664. These efforts molecules that incorporate piperazate building blocks resulted discovery and structural elucidation two dimeric biaryl-cyclohexapeptides, petrichorins A B. Petrichorin B is symmetric homodimer similar known compound chloptosin, but petrichorin unique...
In this study we present a data-driven method called false negative control (FNC) screening to address the challenge of detecting weak signals in underpowered genome-wide association studies (GWASs), where true are often obscured by large amount noise. Our approach focuses on controlling negatives and efficiently regulates proportion at user-specified level realistic settings with arbitrary covariance dependence between variables. We calibrate overall using parameter that aligns existing...
SUMMARY Profiling the binding of T cell receptors (TCRs) cells to antigenic peptides presented by MHC proteins is one most important unsolved problems in modern immunology. Experimental methods probe TCR-antigen interactions are slow, labor-intensive, costly, and yield moderate throughput. To address this problem, we developed pMTnet-omni, an Artificial Intelligence (AI) system based on hybrid protein sequence structure information, predict pairing TCRs αβ with peptide-MHC complexes (pMHCs)....
Polygenic risk score (PRS) is a quantity that aggregates the effects of variants across genome and estimates an individual's genetic predisposition for given trait. PRS analysis typically contains two input data sets: base effect size estimation target individual-level prediction. Given availability large-scale data, it becomes more common ancestral background do not perfectly match. In this paper, we treat GWAS summary information obtained in as knowledge learned from pre-trained model,...
Abstract The geographic ranges in which species live is a function of many factors underlying ecological and evolutionary contingencies. Observing the range an individual provides valuable information about these historical contingencies for lineage, determining distribution distantly related tandem large‐scale constraints on processes generally. We present linear regression method that allows discrimination various hypothetical biogeographical models landscape distributional pattern best...
Chronic hepatitis B virus (HBV) infection is a global health problem that substantially increases the risk of developing liver disease. The development novel strategy to induce anti-HB seroconversion and achieve long-lasting immune response against chronic HBV remains challenging. Here, we found affected signaling pathway involved in STING-mediated induction host responses dendritic cells (DCs) then generated lymph node-targeted nanovaccine co-delivered surface antigen (HBsAg) cyclic...
Cancers eventually kill hosts even when infiltrated by cancer-specific T cells. We examined whether cell receptors of CD4
ABSTRACT Accurate delineation of functional brain regions adjacent to tumors is imperative for planning neurosurgery that preserves critical functions. Functional magnetic resonance imaging (fMRI) plays an increasingly pivotal role in presurgical counseling and planning. In the analysis fMRI data, impact false negatives on patients surpasses positives because failure identify unintentionally resecting tissues can result severe harm patients. This paper introduces a novel metric, Bayesian...
Abstract Polygenic risk score (PRS) is a quantity that aggregates the effects of variants across genome and estimates an individual’s genetic predisposition for given trait. PRS analysis typically contains two input data sets: base effect size estimation target individual-level prediction. Given availability large-scale data, it becomes more common ancestral background do not perfectly match. In this paper, we treat GWAS summary information obtained in as knowledge learned from pre-trained...