A5042158426- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Hepatitis Viruses Studies and Epidemiology
- Bacteriophages and microbial interactions
- Virology and Viral Diseases
- Respiratory viral infections research
- Trypanosoma species research and implications
- Virus-based gene therapy research
Centers for Disease Control and Prevention
2020-2025
National Center for Immunization and Respiratory Diseases
2020-2023
Center for Disease Control
2023
Abstract Rotavirus is a leading cause of diarrhea among children but less known as adults. We describe clinical, epidemiologic, and genotype characteristics rotavirus outbreak adults in King County, Washington occurring January-June 2023. Adult incidence 2023 was ten times higher than the same period 2022 (5% versus 0.5% samples). Disease severity mild. G9P[4], an uncommon, non-vaccine strain USA, predominant genotype. Genotyping suggested spillover from with subsequent spread Our study...
Rotavirus vaccine evaluations have noted small differences in effectiveness (VE) against rotavirus genotypes, defined by the two outer capsid proteins (VP7 or G-type and VP4 P-type). However, genomic landscape of group A (RVA) impact remaining nine genome segments (i.e., “backbone”) on VE are not fully understood. We incorporated whole sequence (WGS) data to characterize viruses responsible for rotavirus-associated gastroenteritis (RVGE) between vaccinated unvaccinated individuals United...
Rotavirus vaccine evaluations have noted small differences in effectiveness (VE) against rotavirus genotypes, defined by the two outer capsid proteins (VP7 or G-type and VP4 P-type). However, genomic landscape of group A (RVA) impact remaining nine genome segments (i.e., “backbone”) on VE are not fully understood. We incorporated whole sequence (WGS) data to characterize viruses responsible for rotavirus-associated gastroenteritis (RVGE) between vaccinated unvaccinated individuals United...
Rotavirus group A (RVA) is the most common cause of severe childhood diarrhea worldwide. The introduction rotavirus vaccination programs has contributed to a reduction in hospitalizations and mortality caused by RVA. From 2016 2021, we conducted surveillance monitor RVA prevalence genotype distribution Nam Dinh Thua Thien Hue (TT Hue) provinces where pilot Rotavin-M1 vaccine (Vietnam) implementation took place from 2017 2020. Out 6626 stool samples, was detected 2164 (32.6%) ELISA. RT-PCR...
Abstract Rwanda was the first low-income African country to introduce RotaTeq vaccine into its Expanded Programme on Immunization in May 2012. To gain insights overall genetic make-up and evolution of Rwandan G1P[8] strains pre- post-vaccine introduction, rotavirus positive fecal samples collected between 2011 2016 from children under age 5 years as part ongoing surveillance were genotyped with conventional RT-PCR based methods whole genome sequenced using Illumina MiSeq platform. From a...
Introduction: Rotavirus vaccine evaluations have noted small differences in effectiveness (VE) against rotavirus genotypes, defined by the two outer capsid proteins (VP7 or G-type and VP4 P-type). However, genomic landscape of group A (RVA) impact remaining nine genome segments (i.e., "backbone") on VE are not fully understood. We incorporated whole sequence (WGS) data to characterize viruses responsible for rotavirus-associated gastroenteritis (RVGE) between vaccinated unvaccinated...
Abstract Objective Rotavirus A (RVA) remains the main causative agent of gastroenteritis in young children and many mammalian avian species. In this study we describe a RVA strain detected from 6-month-old child Central African Republic (CAR). Results We report 11 open reading frame sequences G29-P[6]-I2-R2-C2-M2-A2-N2-T2-E2-H2 rotavirus strain, RVA/Human-wt/CAR/CAR91/2014/G29P[6]. Nine genes (VP1–VP3, VP6, NSP1–NSP5) shared 90–100% sequence similarities with genogroup 2 rotaviruses....
Rotavirus (RV) was a common healthcare-associated infection prior to the introduction of RV vaccine. Following widespread vaccination, rotavirus cases are rare. We describe an investigation cluster infections in pediatric hospital which uncommon genotype not typically circulating United States detected.
In this study, we report the detection of a G6P[14] rotavirus strain from human stool sample within United States. The full genotype constellation was identified as G6-P[14]-I2-R2-C2-M2-A11-N2-T6-E2-H3.
This study reports the coding-complete genome sequences of three rotavirus A (RVA) reference strains previously adapted in tissue culture: RVA/Mouse-tc/USA/EDIM/XXXX/G16P[16] with a G16-P[16]-I7-R7-C7-M8-A7-N7-T10-E7-H9 genotype constellation, RVA/Human-tc/USA/Ph158/1998/G9P[6] G9-P[6]-I2-R2-C2-M2-A2-N2-T2-E2-H2 and RVA/Human-tc/USA/CC425/1998/G3P[9] G3-P[9]-I2-R2-C2-M2-A3-N2-T1-E2-H3 constellation.
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Abstract Background Rotavirus group A (RVA) was the most common cause of infectious gastroenteritis among young children before introduction rotavirus vaccine in United States 2006. Following widespread vaccination, U.S. hospital acquired (HA) cases are rare. We describe a cluster infections pediatric with genotype uncommon children. Methods Patient HA gastrointestinal (GI) illness were detected through hospital-wide microbiology surveillance, performed by Infection Prevention and Control...