A5023315675- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Physics of Superconductivity and Magnetism
- Ginseng Biological Effects and Applications
- Glycosylation and Glycoproteins Research
- Magnetic properties of thin films
- Neurological Disease Mechanisms and Treatments
- Oral microbiology and periodontitis research
- Nanoplatforms for cancer theranostics
- Plant-based Medicinal Research
- Magnetic and transport properties of perovskites and related materials
- Biological and pharmacological studies of plants
- Receptor Mechanisms and Signaling
- Click Chemistry and Applications
- Drug Transport and Resistance Mechanisms
- 2D Materials and Applications
- Superconductivity in MgB2 and Alloys
- Retinoids in leukemia and cellular processes
- Phytochemistry and Biological Activities
- Monoclonal and Polyclonal Antibodies Research
- Traditional Chinese Medicine Studies
- Topological Materials and Phenomena
- Pharmacological Effects of Medicinal Plants
- Proteoglycans and glycosaminoglycans research
- Natural product bioactivities and synthesis
Anhui University of Technology
2023-2024
Zhejiang University
2024
Shanghai University of Traditional Chinese Medicine
2020-2022
Max Planck Institute for Chemical Physics of Solids
2022
Beijing Radiation Center
2020
Peking University
2000-2019
Western Sydney University
2019
Center for Life Sciences
2016
Cornell University
1992
Vasoactive intestinal peptide (VIP) activates adenylylcyclase in sympathoadrenal cells at concentrations greater than 10(-6) M. We demonstrate here that two forms of a newly discovered with homology to VIP named pituitary adenylate cyclase-activating polypeptide (PACAP) are much more potent activators signal transduction PC12 cells. Both the 27- and 38-amino acid PACAP elevate cAMP levels stimulate membranes, an EC50 near 10(-9) PACAP38 additionally is activator inositol lipid cascade cells,...
Metabolic labeling of glycans with bioorthogonal reporters has been widely used for glycan imaging and glycoproteomic profiling. One the intrinsic limitations metabolic is lack cell-type selectivity. The recently developed liposome-assisted reporter (LABOR) strategy provides a promising means to overcome this limitation, but mechanism LABOR not investigated in detail. In work, we performed mechanistic study on explored its multiplexing capability. Our studies support an endocytosis-salvage...
Abstract The spin–orbit coupling (SOC) lifts the band degeneracy that plays a vital role in search for different topological states, such as insulators (TIs) and semimetals (TSMs). In TSMs, SOC can partially gap degenerate nodal line, leading to formation of Dirac/Weyl (DSMs/WSMs). However, SOC-induced structure along line TSMs has not yet been systematically investigated experimentally. Here, we report direct observation magnetic WSM Co 3 Sn 2 S using high-resolution angle-resolved...
Neu5Ac, Neu5Gc, and KDN are three forms of sialic acids in vertebrates that possess distinct biological functions. Herein, we report the synthesis metabolic incorporation 9-azido analogues acid mammalian cells. The incorporated enable fluorescent imaging cell-surface sialoglycans proteomic profiling sialoglycoproteins. Furthermore, apply them to metabolically engineer cell surfaces with terminated or their analogues. remodeled cells expressing specific sialoglycoforms show binding affinity...
The Naoxinqing (NXQ) tablet is a standardised proprietary herbal product containing an extract of persimmon leaves (Diospyros kaki) for the management cardio- and cerebrovascular diseases. Although previous reports suggested that efficacy NXQ at least partly mediated by its anti-oxidative property, effect major components has not been studied systematically. For quality control purposes, only analytical methods limited to 3 marker analytes have reported, extent which other affect explored....
Abstract Background OPD and OPD' are the two main active components of Ophiopogon japonicas in Shenmai injection (SMI). Being isomers each other, they supposed to have similar pharmacological activities, but actual situation is complicated. The difference hemolytic behavior between vivo vitro was discovered reported by our group for first time. In vitro, only showed hemolysis reaction, while vivo, both caused hemolysis. primary cause has been confirmed be related physical chemical properties...
Ophiopogonin D (OPD) and <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:msup> <a:mrow/> <a:mrow> <a:mo>′</a:mo> </a:mrow> </a:msup> </a:math> (OPD <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" id="M2"> <c:msup> <c:mrow/> <c:mrow> <c:mo>′</c:mo> </c:mrow> </c:msup> </c:math> ) are two bioactive ingredients in Ophiopogon japonicus. Previously published studies have often focused on the therapeutic effects related to OPD’s antioxidant capacity but underestimated...
Ethnopharmacological relevance: JinHong Formula (JHF) was from the famous prescription for appendicitis: Rhubarb and Moutan Decoction. It first recorded in classic of “Jingui Yaolve” written by Zhang Zhongjing. JHF is a promising traditional Chinese medicine (TCM) with broad application treating inflammatory diseases. However, clinical effects sepsis its comprehensive mechanisms remained largely unknown.Aim study: The aim this study to evaluate effect treatment try explore mechanism network...
Abstract Background OPD and OPD’ are the two main active monomers of Ophiopogon japonicus in Shenmai injection, being isomers each other with same chemical formula similar structure. According to common sense, they supposed have pharmacological activities, but actual situation is exactly opposite. The difference distinct hemolytic behavior between vivo vitro was discovered reported by our group for first time. In hemolysis experiment vitro, only showed reaction, while vivo, both revealed...
Abstract Background : OPD and OPD' are the two main active components of Ophiopogon japonicas in Shenmai injection (SMI). Being isomers each other, they supposed to have similar pharmacological activities, but actual situation is complicated. The difference hemolytic behavior between vivo vitro was discovered reported by our group for first time. In , only showed hemolysis reaction, while both caused hemolysis. primary cause has been confirmed be related physical chemical properties OPD',...
Abstract Background : OPD and OPD' are the two main active components of Ophiopogon japonicas in Shenmai injection (SMI). Being isomers each other, they supposed to have similar pharmacological activities, but actual situation is complicated. The difference hemolytic behavior between vivo vitro was discovered reported by our group for first time. In , only showed hemolysis reaction, while both caused hemolysis. primary cause has been confirmed be related physical chemical properties OPD'....