A5079913874- Infant Nutrition and Health
- Erythrocyte Function and Pathophysiology
- Ubiquitin and proteasome pathways
- Neonatal Respiratory Health Research
- Peptidase Inhibition and Analysis
- Fungal Infections and Studies
- Inflammasome and immune disorders
- Galectins and Cancer Biology
- Anesthesia and Pain Management
- Essential Oils and Antimicrobial Activity
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Organophosphorus compounds synthesis
- Immunotherapy and Immune Responses
- Inflammation biomarkers and pathways
- Protease and Inhibitor Mechanisms
- Laser Applications in Dentistry and Medicine
- Bacterial biofilms and quorum sensing
- Research on Leishmaniasis Studies
- Radiomics and Machine Learning in Medical Imaging
- Bee Products Chemical Analysis
- AI in cancer detection
- Lysosomal Storage Disorders Research
- Advanced Neural Network Applications
- Venous Thromboembolism Diagnosis and Management
Sun Yat-sen University
2021-2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Guangdong Polytechnic of Science and Technology
2024
Hebei University
2023
China Medical University
2023
Huizhou Central People's Hospital
2022
Sichuan University
2021
West China Hospital of Sichuan University
2021
Fungal keratitis (FK) remains a treatment challenge, necessitating new therapeutic targets. Piezo1, mechanosensitive ion channel, regulates calcium signaling and immune cell function. This study investigates its role in macrophage-mediated antifungal responses FK. Piezo1 Pyrin expression corneas bone marrow-derived macrophages (BMDMs) were assessed by RNAseq, quantitative real-time PCR (qRT-PCR), Western blot, immunofluorescence. Intracellular concentration was detected Fluo-4 AM fluorescent...
Abstract Fungal pathogens are common causes of superficial clinical infection. Their increasing drug resistance gradually makes existing antifungal drugs ineffective. Heat stable factor (HSAF) is a novel natural product with unique structure. However, the application HSAF has been hampered by very low yield in current microbial producers and from extremely poor solubility water solvents. In this study, we developed an effective mode treatment applying to fungal infections. The marine‐derived...
Galectin-3 is one of the galectin family members which are master regulators immune homeostasis, especially in infectious diseases. However, its mechanism regulation fungal keratitis has not been thoroughly studied. Our study aimed at clarifying role galectin-3 mouse model vivo, thereby providing a new biomarker antifungal therapy. In our study, aspergillus, most common pathogenic fungi keratitis, was identified and isolated by corneal tissue fungus culture. Then, RNA expression levels...
PurposeTo investigate the efficiency and underlying mechanism of myeloid-derived suppressor cells (MDSCs) in corneal alkali burns (CAB).MethodsCD11b+ Gr-1+ from C57BL/6J mice bone marrow were cultured induced. Cell activity immunoregulative function assessed by flow cytometry vitro. The ideal strategy MDSCs therapy was slit-lamp microscopy, vivo. therapeutic effects critical signaling pathway investigated hematoxylin-eosin (HE) staining, cytometry, immunofluorescence. expression level NLRP3...
Fungal keratitis, one of the most common infectious eye diseases in China, often results a poor prognosis due to delayed diagnosis and insufficiency effective therapy. There is an urgent need identify specific biomarkers for disease. In this study, we screened out tear proteins patients with fungal keratitis by microsphere-based immunoassay analysis. Levels cytokine expression were determined both human corneal epithelial cell models vitro corneas western blot, quantitative polymerase chain...
Abstract Antibiotic resistance in gram‐negative pathogens has become one of the most serious global public health threats. The role N ‐acyl homoserine lactone (AHL)‐mediated signaling pathway, which is widespread bacteria, bacterial process should be studied depth. Here, we report a degrading enzyme AHLs, MomL, that inhibits antibiotic Pseudomonas aeruginosa through novel mechanism. MomL‐mediated reactivation kanamycin highly associated with relA ‐mediated starvation stringent response....
Clear cell renal carcinoma (ccRCC) represents the most frequent form of (RCC), and accurate International Society Urological Pathology (ISUP) grading is crucial for prognosis treatment selection.This study presents a new deep network called Multi-scale Fusion Network (MsfNet), which aims to enhance automatic ISUP grade ccRCC with digital histopathology pathology images.The MsfNet overcomes limitations traditional ResNet50 by multi-scale information fusion dynamic allocation channel...