A5073954668- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Brain Tumor Detection and Classification
- Cell death mechanisms and regulation
- Thyroid Disorders and Treatments
- Soil and Unsaturated Flow
- Stroke Rehabilitation and Recovery
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Peroxisome Proliferator-Activated Receptors
- Photoacoustic and Ultrasonic Imaging
- Groundwater flow and contamination studies
- Metabolism and Genetic Disorders
- CO2 Sequestration and Geologic Interactions
- Heme Oxygenase-1 and Carbon Monoxide
- Genetic Associations and Epidemiology
Ningbo University Affiliated Hospital
2024
Zhejiang University
2022-2024
Ningbo University
2023-2024
Shanghai East Hospital
2023
Ningbo First Hospital
2018-2022
Background and Purpose: This study aimed to evaluate the treatment effect of intraarterial versus intravenous tirofiban during endovascular thrombectomy in acute ischemic stroke. Methods: retrospectively examined 503 patients with stroke large vessel occlusion who received within 24 hours onset. Patients were divided into 3 groups: no (n=354), (n=79), (n=70). The groups compared terms recanalization rate, symptomatic intracerebral hemorrhage, in-hospital death 3-month death, outcomes...
Background and Purpose— This study aimed to explore safety of tirofiban in endovascular treatment acute ischemic stroke. Methods— Two hundred eighteen stroke patients receiving thrombectomy were prospectively recruited, with 94 treated intra-arterial 124 not. The 2 groups compared terms symptomatic intracranial hemorrhage (ICH) fatal ICH rate by the χ test logistic regression. Results— Patients those without had significantly higher (14.6% versus 5.7%; P =0.027) (8.8% 1.6%; =0.014)....
Introduction: Our collaborative team has previously developed a prognostic model for acute ischemic stroke (AIS). This model, known as the clinical decision support system (CDSS), aims to provide personalized assistance clinicians in making treatment decisions and improving patient prognosis. The objective of this study was externally validate using Chinese AIS patients. Methods: All enrolled patients arrived at hospital within 24 hours after onset. primary outcome likelihood favorable...
Background To evaluate the causal relationship between lipoprotein(a) Lp(a) and stroke risk. Method Adopting two grand scale genome-wide association study (GWAS) databases, instrumental variables were selected on basis that genetic loci met criteria of being independent each other closely related to Lp(a). Summary-level data for outcomes, ischemic its subtypes acquired from UK Biobank MEGASTROKE consortium databases. Two-sample MR analyses achieved using inverse variance-weighted (IVW)...
Atrial fibrillation (AF) is associated with poorer functional outcomes in acute stroke patients. It has been hypothesized that this due to poor collateral recruitment.This study aimed investigate the relationship between AF and collaterals outcome thrombectomy patients.This retrospective cohort identified 1036 ischemic patients from INternational Stroke Perfusion Imaging REgistry. The was divided into two groups: 432 604 without AF. Patients were stratified by grades as good, moderate, poor....
Objective We hypothesized that quantitative net water uptake (NWU), a novel neuroimaging marker of early brain edema, can predict symptomatic intracranial hemorrhage (sICH) after acute ischemic stroke (AIS). Methods enrolled patients with AIS who completed admission multimodal computed tomography (CT) within 24 h onset. NWU the core and penumbra was calculated based on CT, namely NWU-core NWU-penumbra. sICH defined as presence ICH in infarct area 7 days onset, accompanied by clinical...
To investigate the difference in early edema, quantified by net water uptake (NWU) based on computed tomography (CT) between ischemic core and penumbra to explore predictors of NWU test its predictive power for clinical outcome.Retrospective analysis was conducted patients admitted Ningbo First Hospital with anterior circulation stroke multi-modal CT. In 154 included patients, were calculated compared Mann-Whitney U test. Correlations variables including age, infarct time (time from symptom...
Abstract BACKGROUND AND PURPOSE Tenecteplase was demonstrated pharmacological superiority over alteplase, potentially translating into clinical benefits. Numerous studies have confirmed that the effectiveness and safety of tenecteplase in acute ischemic stroke (AIS) treatment may not be inferior to it has potential workflow advantages. This study aimed evaluate whether tenecteplase’s use routine practice time management advantages corresponding METHODS The included AIS patients treated with...
Background This retrospective observational cohort study aimed to evaluate whether tenecteplase’s use for acute ischemic stroke (AIS) has time management advantages and clinical benefits. Methods 144 AIS patients treated with alteplase 120 tenecteplase were included. We compared baseline characteristics, key reperfusion therapy indices [onset-to-treatment (OTT), door-to-needle (DNT), door-to-puncture (DPT)] outcomes (24-h post-thrombolysis NIHSS improvement, intracranial hemorrhage...
Background and aim Good collateral circulation is recognized to maintain perfusion contribute favorable clinical outcomes in acute ischemic stroke. This study aimed derive validate an optimal time measurement on computed tomography imaging for patients with Methods included 106 stroke complete large vessel occlusions. In deriving cohort of 23 patients, the parasagittal region hemisphere was divided into six pial arterial zones according branches middle cerebral artery. Within 85 vessels,...
The study aimed to explore the association between midline shift (MLS) and net water uptake (NWU) within ischemic penumbra in acute stroke patients.This was a retrospective cohort that examined patients with anterior circulation stroke. Net core calculated using data from admission multimodal CT scans. primary outcome severe cerebral edema measured by presence of MLS on 24 48 h follow-up significant defined deviation septum pellucidum scans at least 3 mm or greater due mass effect edema....
Abstract Background Severe cerebral edema (CED) increases the poor prognosis and mortality rate of acute ischemic stroke (AIS) reduces benefit intravascular therapy. Uric acid (UA) has been reported to possess a potential protective effect against AIS. The aim our study was explore association between UA severe CED after Method We conducted retrospective cohort patients with large vascular occlusion (LVO-AIS) who underwent endovascular thrombectomy (EVT) had an mTICI grade 2b-3 EVT. A total...
Abstract Background The effectiveness of Tirofiban administration to acute ischemic stroke patients undergoing endovascular thrombectomy (EVT) after intravenous thrombolysis (IVT) remains unclear. This study examined the effect intraarterial or tirofiban during following thrombolysis. Methods Patients with who received EVT were selected from International Stroke Perfusion Imaging Registry, and divided into three groups according administration. Safety outcomes symptomatic intracerebral...
Objective To review the experience on screening, diagnosis and treatment for neonatal congenital hypothyroidism (CH) in Xuancheng City, Anhui Province. Methods From Jan 2008 to Dec 2014, peripheral blood samples from heel were collected among 83 787 neonates sent screening center test level of thyroid stimulating hormone (TSH). Neonates with abnormal TSH admitted our hospital further free tetraiodothyronine (FT4) tests. CH given standard treatments levothyroxine their function,...
1Department of Neurology, Ningbo First Hospital, Haishu District, Ningbo, Zhejiang, PR China 2Department Neurosurgery, Li Hui Hospital City Medical Treatment Cente, Yinzhou Supported by the Traditional Chinese Medicine Science and Technology Project Zhejiang Province (grant no. 20182A107). The authors have no conflicts interest to declare. Yufei Wu conceived designed study. J. Yang performed literature search data extraction. Z. He analyzed data. Yuefei drafted manuscript.