A5076312089- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Lymphocytic Leukemia Research
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- T-cell and Retrovirus Studies
- Advanced Chemical Sensor Technologies
- Pediatric health and respiratory diseases
- Gastric Cancer Management and Outcomes
- Congenital Diaphragmatic Hernia Studies
- Transplantation: Methods and Outcomes
- Air Quality and Health Impacts
- CNS Lymphoma Diagnosis and Treatment
- Nursing Diagnosis and Documentation
- Cystic Fibrosis Research Advances
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
New York University
2024-2025
Hebrew University of Jerusalem
2021-2024
Hadassah Medical Center
2015-2024
Pulmonary and Critical Care Associates
2024
SleepMed
2024
University Medical Center
2015
Abstract The role of dietary fiber in colon cancer prevention remains controversial. We investigated its impact on anti-tumor immunity and the gut microbiota APCmin/+ mice infected with Enterotoxigenic Bacteroides fragilis. Mice were fed high-fiber, low-fiber, or chow diets, tumor burden, survival, cytokines, microbiota, metabolites analyzed. Contrary to belief that high inhibits progression, it had no significant compared diet. However, low-fiber diet significantly reduced burden improved...
<p>Supplementary Figure S7 shows that how dietary fiber modulates gut microbiota composition and immune landscape in ETBF-inoculated APCmin/+ mice. Mice were fed normal chow, a low-fiber diet, or high-fiber diet for 8 weeks. Cecal was analyzed using 16S rRNA gene sequencing. Panel A alpha diversity based on the Shannon index, with significant differences between groups. B presents beta analysis PCoA, revealing C depicts relationship landscape, as determined by RDA ordination....
<p>Supplementary Figure S8 examines the impact of dietary fiber on fecal bile acid profiles in ETBF-inoculated APCmin/+ mice. Fecal acids were analyzed using LC-MS, comparing high-fiber and low-fiber diet groups. Panel A shows primary colon contents. B compares secondary between two groups.</p>
<p>Supplementary Figure S1 shows the impact of dietary fiber intake on colorectal carcinogenesis. Panel A displays representative H&E-stained images colon tissues from mice fed either a normal chow or low-fiber diet 8 weeks post-ETBF inoculation. B quantifies tumor numbers in APCmin/+ different diets. C body weight changes over time for each group.</p>
<p>Supplementary Figure S4 shows the effects of dietary fiber on IL-17A-producing RORgt+ Tregs in ETBF-inoculated APCmin/+ mice. Panel A presents flow cytometry analysis percentage RORγt+ LPLs mice fed normal chow, low-fiber, or high-fiber diets 8 weeks post-ETBF. B quantifies these cells across diet groups.</p>
<p>Supplementary Figure S5 shows the growth response of ETBF to a high-fiber diet in APCmin/+ mice. Mice were inoculated with at day 0 and fed either low-fiber or diet. Fecal samples collected designated time points, expression B. fragilis toxin 2 (BFT-2) was measured using qPCR as surrogate for abundance. The relative percentage each point calculated pre-inoculation levels.</p>
<div>Abstract<p>The role of dietary fiber in colon cancer prevention remains controversial. We investigated its impact on antitumor immunity and the gut microbiota <i>APC</i><sup><i>min/+</i></sup> mice infected with enterotoxigenic <i>Bacteroides fragilis</i>. Mice were fed high-fiber, low-fiber, or chow diets, tumor burden, survival, cytokines, microbiota, metabolites analyzed. Contrary to belief that high inhibits progression, it...
<p>Supplementary Figure S3 shows the impact of dietary fiber composition on immune cell subsets in ETBF-inoculated APCmin/+ mice. Flow cytometric (FACS) and CyTOF analyses were conducted to evaluate populations spleen, mesenteric lymph nodes (MLN), lamina propria lymphocytes (LPLs) 8 weeks post-inoculation. Panels A–C display frequencies neutrophils, monocytes, myeloid-derived suppressor cells, macrophages, dendritic cells MLN, LPLs, respectively. Panel D provides a tSNE plot from...
<p>Supplementary Figure S6 shows that gut microbiota are essential for high-fiber diet-mediated colorectal tumorigenesis. APCmin/+ mice inoculated with ETBF were fed either a low-fiber or diet, without antibiotic treatment, to deplete microbiota. Colon tumor numbers quantified, highlighting the dependency of tumorigenesis on microbiota.</p>
<p>Supplementary Figure S2 shows the modulation of colon cytokine and chemokine expression patterns by dietary fiber. ETBF/APCmin/+ mice were fed different diets tissues analyzed 8 weeks post-infection to quantify 23 cytokines chemokine.</p>
Acute cellular rejection (ACR) after lung transplant is a leading risk factor for chronic allograft dysfunction. Prior studies have demonstrated dynamic microbial changes occurring within the and gut that influence local adaptive innate immune responses. However, microbiome's overall impact on ACR remains poorly understood.
Combination of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) is regarded as standard care for diffuse large B-cell lymphoma (DLBCL) upfront intensification therapy still controversial. The current study aimed to dertermine whether the addition high-dose methotrexate (HDMTX) affects long-term outcomes could also prevent central nervous system (CNS) relapse. Medical records 480 patients with DLBCL treated between 1994 2013 at Rambam Hadassah medical centers in...
Background Nucleic acid amplification tests (NAAT) are considered the gold standard for COVID-19 diagnosis. These require professional manpower and equipment, long processing swab sampling which is unpleasant to patients. Several volatile organic compounds (VOCs) have been identified in breath of Detection these VOCs using a test could help rapidly identify
Chronic lymphocytic lymphoma (CLL) can be associated with several malignancies, but rarely myelofibrosis. Only isolated case reports in the literature described association between CLL and primary myelofibrosis (PMF) same patient. We describe a of characterized by development PMF review literature. an 86-year-old female diagnosed as having followed splenomegaly progressively rising LDH levels 27 months later. A bone marrow biopsy was consistent diagnosis PMF, positive JAK-2 V617F mutation....