A5040510963- Phagocytosis and Immune Regulation
- Biomedical and Engineering Education
- Cancer, Stress, Anesthesia, and Immune Response
- Adipokines, Inflammation, and Metabolic Diseases
- Biomedical Ethics and Regulation
- Diabetes and associated disorders
- IL-33, ST2, and ILC Pathways
- Ethics in Clinical Research
- Lipid metabolism and disorders
- Cytokine Signaling Pathways and Interactions
- Wound Healing and Treatments
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Antimicrobial Peptides and Activities
- Neuroscience of respiration and sleep
- Pluripotent Stem Cells Research
- Atherosclerosis and Cardiovascular Diseases
- Asthma and respiratory diseases
- Pancreatic function and diabetes
- Helicobacter pylori-related gastroenterology studies
- Neuropeptides and Animal Physiology
Wuhan No.1 Hospital
2016-2021
Huazhong University of Science and Technology
2016-2021
Central South University
2013-2015
Heidelberg University
1990
Sustained activation of NLRP3 inflammasome and release neutrophil extracellular traps (NETs) impair wound healing diabetic foot ulcers (DFUs). Our previous study reported that milk fat globule epidermal growth factor VIII (MFG-E8) attenuates tissue damage in systemic lupus erythematosus. However, the functional effect MFG-E8 on "NLRP3 inflammasome-NETs" inflammatory loop diabetes is not completely elucidated. In this study, neutrophils from DFU patients are susceptible to undergo NETosis,...
Summary Interleukin ( IL )‐17A is a pro‐inflammatory cytokine that markedly enhances inflammatory responses in the lungs by recruiting neutrophils and interacting with other mediators. Reducing expression of ‐17A could attenuate inflammation lungs. However, whether VIP exerts its anti‐inflammatory effects regulating has remained unclear. Here, we show there remarkable increase bronchoalveolar lavage fluid BALF ) lung tissue mice acute injury ALI ). Moreover, lipopolysaccharides LPS...
Milk fat globule-epidermal growth factor 8 (MFG-E8) is the key mediator in anti-inflammatory responses that facilitate phagocytosis of apoptotic cells, and play an essential role type 2 diabetes pregnancy, both which are under a low-grade inflammatory state. However, action MFG-E8 gestational mellitus (GDM) unclear. We measured plasma levels pregnancy GDM for first time, elucidated possible relationships between its various metabolic parameters.Plasma were quantified by enzyme-linked...
Abstract Inflammation is the most important link between obesity and type 2 diabetes (T2D). Although milk fat globule‐epidermal growth factor 8 (MFG‐E8) a key mediator in anti‐inflammatory responses, its role not yet completely understood. We aimed to measure MFG‐E8 serum levels explore of T2D. Fasting were quantified by enzyme‐linked immunosorbent assay for 168 individuals, whose oral glucose tolerance test was conducted, inflammatory factors, including tumor necrosis factor‐α (TNF‐α)...
Abstract Angiopoietin-like 8 (ANGPTL8) is closely linked to obesity-associated metabolic diseases and insulin resistance. The aim of the current study was investigate ability ANGPTL8 reverse resistance in obese mice. administration reduced weight gain improved glucose tolerance mice with diet-induced obesity. In addition, modified macrophage infiltration, monocyte chemoattractant protein-1 (MCP-1) interleukin-1β(IL-1β) levels, increased adiponectin gene expression inguinal white adipose...
Over the last few decades, China has greatly expanded its scope of stem cell research, generating various scientific advances and medical applications. However, knowledge extent characteristics domestic development, particularly workers’ opinions, is lacking. This study’s purposes were to analyze growth trends China’s community identify attitudes held by Chinese workers regarding research. We found that there are currently 13 high-quality research centers with more than 400 PhD-level...