A5079345119- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Pregnancy and Medication Impact
- Neuroscience and Neuropharmacology Research
- Reproductive Health and Contraception
- Neonatal and fetal brain pathology
- Diabetes Treatment and Management
- Neuroendocrine regulation and behavior
- Hypothalamic control of reproductive hormones
- Diabetes Management and Research
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Bariatric Surgery and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Hormonal and reproductive studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Risk Factors
- Estrogen and related hormone effects
- Menstrual Health and Disorders
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diabetes Management and Education
- Dementia and Cognitive Impairment Research
Brigham and Women's Hospital
2024
Joslin Diabetes Center
2014-2022
Beth Israel Deaconess Medical Center
2006-2017
Columbia University
2017
North Shore University Hospital
2012
University of Southern California
2012
Thomas Jefferson University Hospital
2012
Cornell University
2012
Newton Wellesley Hospital
2009
University of Virginia
2009
To assess progesterone treatment of intractable seizures in women with partial epilepsy.This randomized, double-blind, placebo-controlled, phase III, multicenter, clinical trial compared the efficacy and safety adjunctive cyclic natural therapy vs placebo 294 subjects randomized 2:1 to or placebo, stratified by catamenial noncatamenial status. It treatments on proportions ≥50% responders changes seizure frequency from 3 baseline treated menstrual cycles.There was no significant difference...
To determine whether rates of unintended pregnancy in women with epilepsy (WWE) vary by contraceptive category and when stratified antiepileptic drug (AED) category.These retrospective data come from the Epilepsy Birth Control Registry (EBCR) web-based survey 1,144 WWE community, 18-47 years age, who provided demographic, epilepsy, AED, contraceptive, data. Participants indicated pregnancies were intended or unintended, as well type AED used at conception. We report failure relative to...
Abstract This investigation assessed the frequency of catamenial epilepsy in 87 women who charted seizures and menses during three cycles. Catamenial designation was made if two cycles showed at least one previously defined patterns. Among ovulatory cycles, average daily seizure significantly greater perimenstrual preovulatory phases. anovulatory substantially less midfollicular phase than remainder cycle. Overall, 39.1% had epilepsy. Ann Neurol 2004;56:431–434
Previous reports have suggested that hormone replacement therapy (HRT) could increase seizure activity in women with epilepsy. We sought to determine whether adding HRT the medication regimen of postmenopausal epilepsy was associated an frequency.This a randomized, double-blind, placebo-controlled trial effect on frequency epilepsy, taking stable doses antiepileptic drugs (AEDs), and within 10 years their last menses. After 3-month prospective baseline, subjects were randomized placebo,...
To determine whether 1) combined oral contraceptive (COC) use affects serum levels of valproate (VPA) as well lamotrigine (LTG) and 2) the naturally occurring high (mid-luteal) low (early-mid follicular) reproductive steroid level phases menstrual cycle might affect antiepileptic drug well.This investigation compared at two timepoints during a single in four groups women with epilepsy: 12 on VPA, VPA plus COC (VPA-COC), LTG, LTG (LTG-COC).Both were lower (p < 0.01) active than inactive pill...
<h3>Importance</h3> Inflammation may contribute to pathological associations among obesity, diabetes mellitus, and cardiovascular disease. <h3>Objective</h3> To determine whether targeting inflammation using salsalate compared with placebo reduces progression of noncalcified coronary artery plaque. <h3>Design, Setting, Participants</h3> In the Targeting Using Salsalate in Cardiovascular Disease (TINSAL-CVD) trial participants were randomly assigned between September 23, 2008, July 5, 2012,...
Summary Objective To report the contraceptive practices of women with epilepsy ( WWE ) in community, predictors highly effective contraception use, and reasons provide for selection a particular method. Methods These cross‐sectional data come from Epilepsy Birth Control Registry EBCR web‐based survey regarding 1,144 ages 18–47 years. We demographic, epilepsy, antiepileptic drug AED characteristics as well use. determined frequency use that is, methods failure rate <10%/year, conducted...
Objective: The temporal distribution of seizures in women with localization-related epilepsy occurs periodically according to a model “clock” the peak phase occurrence corresponding menstrual onset. location and laterality epileptic lesion as well patient age may affect periodicity.Methods: Baseline data from seizure diaries ∼3 months duration were obtained 100 enrolled trial hormonal therapy for epilepsy. Durations individual cycles normalized common period. Normalized then combined create...
Summary The purpose of this study was to determine whether seizure frequency and cycle days with occurrence vary across the menstrual cycle. subjects were first 100 women intractable focal onset seizures, 13–45 years old, who completed baseline phase National Institutes Health ( NIH ) Progesterone Trial. Each subject recorded seizures menses during a 3‐month phase. Data consisted (1) numbers for each day (2) occurrence. Statistical comparisons performed using generalized estimating equation...
Abstract Context Plasma betaine correlates with insulin sensitivity in humans. Betaine supplementation improves metabolic effects mice fed a high-fat diet. Objective To assess of oral obese participants prediabetes. Design A 12-week, parallel arm, randomized, double-masked, placebo-controlled trial. Setting University-affiliated hospital. Participants and Interventions Persons obesity prediabetes (N = 27) were randomly assigned to receive 3300 mg orally twice daily for 10 days, then 4950 12...
Purpose: To determine if seizure frequency differs between anovulatory and ovulatory cycles. Methods: The data came from the 3-month baseline phase of an investigation progesterone therapy for intractable focal onset seizures. Of 462 women who enrolled, 281 completed 92 had both cycles during phase. Midluteal levels ≥5 ng/ml were used to designate as ovulatory. Among women, average daily (ADSF) all seizures combined each type considered separately (secondary generalized tonic–clonic –...
The aim of this study was to determine whether categories contraception differ in their impact on seizures women with epilepsy and the varies by antiepileptic drug category.Retrospective survey data came from 2712 contraceptive experiences reported 1144 epilepsy. We compared risk ratios for reports increase decrease seizure frequency hormonal versus nonhormonal contraception, stratified categories.More a change (28.2%) than (9.7%) (p<0.0001). ratio (18.7%) (4.2%) 4.47 (9.5%) (5.5%) 1.71,...
Background: Postbariatric hypoglycemia (PBH) is a complication of bariatric surgery with limited therapeutic options. We developed an event-based system to predict and detect based on continuous glucose monitor (CGM) data recommend delivery minidose liquid glucagon. Methods: performed iterative development clinical study employing novel glucagon system: Dexcom CGM connected Windows tablet running prediction algorithm Omnipod pump filled investigational stable formulation. Meal tolerance...
Summary Purpose: Little consensus exists for the definition of catamenial epilepsy. Few studies have evaluated periodicity seizures to test hypothesis that in women periodic patterns occurrence independent a priori hormonal considerations. In present study, we determined seizure according “menstrual clock” provided by common phase marker onset menses. Methods: Seizure and menstrual diaries ∼3 months duration were obtained from enrolled trial therapy localization‐related Midluteal...
To assess long-term efficacy and safety of salsalate to improve glycemia in persons with diabetes risk, who are overweight statin-treated, stable coronary heart disease.Glycemic status was assessed 192 without at baseline a pre-specified secondary analysis from Targeting INflammation Using SALsalate CardioVascular Disease (TINSAL-CVD), multi-center, double-masked, randomized (1:1), placebo-controlled, parallel clinical trial.Participants were mostly Caucasian males, age 60±7 years, BMI...
Some ovarian steroids such as estradiol (E)1,2 and progesterone (P)3,4 have neuroactive properties that can affect neuronal excitability. Cyclic changes in the serum concentrations of these relation to menstrual cycle may induce variation seizure frequency has been termed catamenial epilepsy.5,6 There is statistical evidence support existence at least three patterns: 1) perimenstrual (C1: day −3 3), 2) periovulatory (C2: 10 −13) ovulatory cycles, 3) luteal (C3: anovulatory cycles. Day 1...
Summary Objective To report the reasons for discontinuation of contraceptive methods by women with epilepsy ( WWE ). Methods These retrospective data come from a web‐based survey regarding practices 1,144 in community, ages 18–47 years. We determined frequencies discontinuations and discontinuation. compared risk ratios rates among categories. used chi‐square analysis to test independence various categories when stratified antiepileptic drug AED ) Results Nine hundred fifty‐nine 2,393...
The aim of this study was to examine the hypothesis that pramlintide would reduce hypoglycaemia by slowing gastric emptying and reducing postprandial glucagon secretion, thus limiting glycaemic excursions insulin determine efficacy on frequency severity in post-bariatric (PBH).Participants with PBH following bypass were recruited from outpatient clinics at Joslin Diabetes Center, Boston, Massachusetts for an open-label over 8 weeks. Twenty-three participants assessed eligibility, 20 had...
Abstract Aims In patients with breast cancer (BCa) and diabetes (DM), distress (DD) treatment satisfaction (DTS) can influence BCa management outcomes. We assessed the impact of implementing a personalized care model in BCa. Methods Patients active or surveillance for an HbA1c > 53 mmol/mol (7%) random blood glucose >11.1 mmol/L were included. Participants offered continuous monitoring (CGM), virtual dedicated provider 6 months. Primary outcomes included DD measured by Diabetes...