A5049919069- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Complement system in diseases
- Eosinophilic Disorders and Syndromes
- Hematological disorders and diagnostics
- Cell Adhesion Molecules Research
- Hemoglobinopathies and Related Disorders
- Neutropenia and Cancer Infections
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- CAR-T cell therapy research
- Bone and Joint Diseases
- Family Support in Illness
- Mesenchymal stem cell research
- Chemokine receptors and signaling
- Oral health in cancer treatment
- Cancer-related cognitive impairment studies
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Brain Metastases and Treatment
Cliniques Universitaires Saint-Luc
1999-2024
UCLouvain
1996-2023
Hôpital de Jolimont
2004-2020
Assistance Publique – Hôpitaux de Paris
2020
Mayo Clinic in Arizona
2020
Pitié-Salpêtrière Hospital
2020
Sorbonne Université
2020
Mayo Clinic
2020
WinnMed
2020
University of Alabama at Birmingham
2020
PURPOSE To evaluate prospectively in patients with follicular lymphoma and a low tumor burden three therapeutic options: delay of any treatment until clinically meaningful progression, immediate an oral alkylating agent, or biologic response modifier, interferon alfa-2b. PATIENTS AND METHODS Newly diagnosed (n = 193) were randomly assigned to one arms: arm 1, no initial 66); 2, prednimustine 200 mg/m2/d for 5 days per month 18 months 64); 3, alfa MU/d 3 then MU times week 15 63). Clinical...
The restricted bone marrow (BM) localisation of multiple myeloma (MM) cells most likely results from a specific homing influenced by chemotactic factors, combined with the proper signals for growth and survival provided BM microenvironment. In analogy to migration normal lymphocytes, one can hypothesise that MM is mediated multistep process, involving concerted action adhesion molecules chemokines. this study, we report primary derived cell lines (Karpas, LP-1 MM5.1) express chemokine...
Objective Although cancer patients frequently experience self-perceived burden to others, this perception has not been enough studied. The aim of study was investigate the prevalence primary caregiver (SPB-PC) and associated factors in an older patient population with hematologic malignancies at time chemotherapy initiation. Methods In total, 166 consecutive aged ≥65 years were recruited Patients' SPB-PC assessed using a 100-mm visual analogue scale (VAS). Characteristics potentially SPB-PC,...
PURPOSE: Most studies using various reverse-transcription polymerase chain reaction (RT-PCR) techniques reported that the detection of AML1-ETO fusion transcript was a common finding in long-term complete remission (CR) acute myeloid leukemia (AML) with t(8;21) translocation. However, larger prospective interlaboratory quality control may be important to investigate more precisely clinical usefulness studying minimal residual disease RT-PCR AML. PATIENTS AND METHODS: We collected 223 marrow...
The 67 kD laminin receptor (67LR) binds laminin-1 (LN), major component of the basement membrane, with high affinity. In this study, we demonstrated that human multiple myeloma cell lines (HMCL) and murine 5T2MM cells express 67LR. CD38bright+ plasma in fresh (MM) bone marrow (BM) samples showed weaker 67LR expression, but expression increased after direct exposure to a BM endothelial line (4LHBMEC). LN stimulated vitro migration 3 HMCL (MM5.1, U266 MMS.1), primary MM cells. has been shown...
Infection is a common adverse event after therapy with nucleoside analogs, including 2-chlorodeoxyadenosine (CdA). However, the incidence of CdA-related infections has been poorly documented. In this study we compare, in same patient population, infectious episodes during 6-month period before CdA to their 6 months initiating therapy. Ninety-five patients hematological malignancies were studied. The almost doubled (0.87 vs. 0.47 pre-CdA period). following factors associated an increased risk...
We evaluated the combination of rituximab with chlorambucil in patients mantle cell lymphoma (MCL) not eligible for aggressive therapy. Fourteen (male/female: 9/5) were included (two newly diagnosed, 12 relapsed/refractory). The toxicities neutropenia, thrombopenia and infection. Nine (64%) responded; five (36%) achieved complete remission four (29%) partial remission. median progression-free survival responders was 26 months (95% CI, 4-48). Marrow polymerase chain reaction negativity...
The use of chemotherapy regimens with moderate or high risk febrile neutropenia (defined as having a FN incidence 10% more) and the respective clinical management in breast cancer NHL has not been studied Belgium. existence medical need for G-CSF primary secondary prophylaxis these was investigated real-life setting. Nine oncologists six hematologists from different Belgian general hospitals university centers were surveyed to collect expert opinion data (year 2007) on patients aged <65...
Although interferon (IFN) has been used in elderly patients with acute lymphoblastic leukemia (ALL), the benefits from IFN therapy have not properly assessed, especially as it was given combined other cytotoxic drugs, which obscured role of if any. In 1997, we started a study aimed at improving our previous results ALL and assessing therapeutic this disease. Fifty-eight ALL, aged 55-81 years (median: 64.9 years), were randomly allocated to treatment vindesine or vincristine during induction....
A few cases of secondary neoplasms occurring after treatment with 2-chloro-2'-deoxyadenosine (2CdA) have been reported, mostly in patients previously exposed to other anti-cancer drugs including alkylating agents (AA). Here we report on the occurrence a myelodysplastic syndrome (MDS) monosomy 5 and/or 7 two 2CdA treatment, without or prior toxic exposure. In light literature review and given involvement chromosomes frequently abnormal leukaemias, suggest that may induce therapy-related MDS (t-MDS).
Flow cytometry of lineage markers is useful in the classification leukemias. Our aim was to assess whether study genes at RNA level would enable differentiation acute myeloid leukemias (AMLs) from B-and T-lineage lymphoid (ALLs).We measured mRNA four [CD19, CD79a, CD3e, and myeloperoxidase (MPO)] by reverse transcription followed real-time quantitative (RTQ)-PCR. We investigated 72 (40 AMLs with 23-93% blast cells plus 27 B-lineage ALLs 5 ALLs) defined morphologic criteria diagnosis. RTQ-PCR...