A5035638643- Global Health Workforce Issues
- Public Health Policies and Education
- Scoliosis diagnosis and treatment
- Connective tissue disorders research
- Food Security and Health in Diverse Populations
- Health Policy Implementation Science
- Congenital heart defects research
- TGF-β signaling in diseases
- Health disparities and outcomes
- Health Sciences Research and Education
- Primary Care and Health Outcomes
- Health Literacy and Information Accessibility
- Genetic factors in colorectal cancer
- Chromosomal and Genetic Variations
- Fibroblast Growth Factor Research
- Meta-analysis and systematic reviews
- Genomic variations and chromosomal abnormalities
- Bat Biology and Ecology Studies
- Air Quality and Health Impacts
- Vestibular and auditory disorders
- Veterinary Orthopedics and Neurology
- Hearing, Cochlea, Tinnitus, Genetics
- Smoking Behavior and Cessation
- Cerebral Palsy and Movement Disorders
- Cancer-related molecular mechanisms research
Marymount University
2023-2024
University of Colorado Anschutz Medical Campus
2018-2024
University of Colorado Denver
2023
Oregon National Primate Research Center
2014-2016
Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys great apes. Here we present assembly analysis northern white-cheeked gibbon (Nomascus leucogenys) genome. We describe propensity for gibbon-specific retrotransposon (LAVA) to insert into chromosome segregation genes alter transcription by providing premature termination site, suggesting possible molecular mechanism...
Nadav Ahituv, Nicola Illing, Jeff Wall and colleagues sequence the genome of bat Miniopterus natalensis perform RNA-seq ChIP-seq (H3K27ac H3K27me3) analyses on its developing forelimb hindlimb autopods at sequential embryonic stages. Their identify genomic regions that may contribute to wing formation. Bats are only mammals capable powered flight, but little is known about genetic determinants shape their wings. Here we generated a for performed stages decipher molecular events underlie...
Objective: Systematic reviews hold immense promise as tools to highlight evidence-based practices that can reduce or aim eliminate racial health disparities. Currently, a national consensus on centering equity in systematic and other evidence synthesis products is lacking.Study Design Setting: This Cochrane US Network team colleagues, with the guidance of steering committee, sought understand views varied interest holders through semi-structured interviews listening exercise, conducted...
Idiopathic scoliosis (IS) is a spinal disorder affecting up to 3% of otherwise healthy children. IS has strong familial genetic component and believed be genetically complex due significant variability in phenotype heritability. Previous studies identified putative loci variants possibly contributing susceptibility, including within extracellular matrix, cilia, actin networks, but the architecture underlying mechanisms remain unresolved. Here, we used whole-exome sequencing from three...
Idiopathic scoliosis (IS) is a structural lateral spinal curvature of ≥10° that affects up to 3% otherwise healthy children and can lead life-long problems in severe cases. It well-established IS genetic disorder. Previous studies have identified genes may contribute the phenotype, but overall etiology not well understood. We used exome sequencing study five multigenerational families with IS. Bioinformatic analyses unique low frequency variants (minor allele ≤5%) were present all sequenced...
Adolescent idiopathic scoliosis (AIS) is a lateral spinal curvature >10° with rotation that affects 2-3% of healthy children across populations. AIS known to have significant genetic component, and despite handful risk loci identified in unrelated individuals by GWAS next-generation sequencing methods, the underlying etiology condition remains largely unknown. In this study, we performed exome affected within 23 multigenerational families, hypothesis occurrence rare, low frequency,...
Epigenetic mechanisms may contribute to idiopathic scoliosis (IS). We identified 8 monozygotic twin pairs with IS, 6 discordant (Cobb angle difference > 10°) and 2 concordant ≤ 2°). Genome-wide methylation in blood was measured the Infinium HumanMethylation EPIC Beadchip. tested for differences variability between twins association curve severity all twins. Differentially methylated region (DMR) analyses gene promoter regions. Methylation at cg12959265 (chr. 7 DPY19L1) less variable cases...
Objective: Systematic reviews are a useful tool to evaluate interventions that have the potential reduce racial health inequities. We aim 1) assess methods center equity in evidence syntheses, and 2) types of evaluated for advancing equity.Study design methods: searched MEDLINE, Cochrane Campbell databases syntheses focused on racialized populations mitigate inequities, published from January 2020 2023.Results: included 157 focusing populations. Only 22 (14%) studies defined role racism...
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Vertigo due to vestibular dysfunction is rare in children. The elucidation of its etiology will improve clinical management and the quality life patients. Genes for were previously identified patients with both hearing loss vertigo. This study aimed identify rare, coding variants children peripheral vertigo but no loss, potentially overlapping phenotypes, namely, Meniere’s disease or idiopathic scoliosis. Rare selected from exome sequence data 5 American vertigo, 226 Spanish disease, 38...
Background: Idiopathic scoliosis is a common structural spine curvature of unknown etiology. Scoliosis onset and progression are likely related to the interplay between genetics environment. Serum protein levels influenced by both genetic environmental factors thus, promising methodology. Aims: We aimed determine whether serum differed idiopathic cases controls. In cases, we also if were correlated with curve severity. Methods: discovery population, blood samples obtained from 7 females...
<sec> <title>BACKGROUND</title> The websites of prominent public health and healthcare organizations play pivotal roles in ensuring access to quality information, including information guiding equity. Several initiatives have been developed the United States promote equitable, fair, inclusive practices across websites. Currently, disparities racial groups are recognized as a critical problem. Simultaneously, use term “racial equity/equities” has rising academic literature. However,...