A5079248426- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Complement system in diseases
- Cell Adhesion Molecules Research
- Immune cells in cancer
- CAR-T cell therapy research
Babraham Institute
2024
University of Cambridge
2022-2024
University Hospital Bonn
2023
The integrin lymphocyte function–associated antigen 1 (LFA-1) helps to coordinate the migration, adhesion, and activation of T cells through interactions with intercellular adhesion molecule (ICAM-1) ICAM-2. LFA-1 is activated during engagement chemokine receptors cell receptor (TCR) inside-out signaling, a process that partially mediated by phosphoinositide 3-kinase (PI3K) its product phosphatidylinositol 3,4,5-trisphosphate (PIP 3 ). To evaluate potential roles PI3K in activation, we...
Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in requires that NK present within tissues a quiescent state. Mechanisms by which remain incompletely elucidated. The transcriptional repressor BACH2 plays the adaptive system, but its function innate lymphocytes has been unclear. Here, we show acts as an intrinsic negative regulator of cell maturation function. is expressed developing mature promotes maintenance immature restricting their...
Abstract Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet molecular components required their and effector functions remain incompletely defined. Inactivation VPS34 in Treg led to an early, lethal phenotype, with massive cell activation inflammation, like mice lacking completely. However, VPS34-deficient developed normally, populated peripheral lymphoid organs effectively supressed conventional vitro . Our data suggest that is maturation or mature...
Abstract NKT cells are unconventional T whose biological role is incompletely understood. Similar to TH cells, activated can cause dendritic cell (DC) maturation, which required for effective CTL responses. However, it unclear whether and how affect CTLs downstream of the DC maturation phase. This partially due lack techniques conditionally deplete in vivo. To overcome this problem, we have developed two approaches purpose mice: first based on mixed bone marrow chimeras where Jα18 knockout...