A5033557058- Exercise and Physiological Responses
- Heat shock proteins research
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Thermoregulation and physiological responses
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Endoplasmic Reticulum Stress and Disease
- Physical Activity and Health
- Renal Diseases and Glomerulopathies
- Cardiovascular Effects of Exercise
- Heart Rate Variability and Autonomic Control
- Sports Performance and Training
- Biochemical effects in animals
- thermodynamics and calorimetric analyses
- Physical Education and Gymnastics
- Phagocytosis and Immune Regulation
- Healthcare Regulation
- interferon and immune responses
- Sphingolipid Metabolism and Signaling
- Systemic Sclerosis and Related Diseases
- Effects of Radiation Exposure
- Sirtuins and Resveratrol in Medicine
- Viral-associated cancers and disorders
- Genetics, Aging, and Longevity in Model Organisms
- Medical research and treatments
Universidade Federal do Rio Grande do Sul
2017-2024
Centro Universitário Metodista IPA
2019
University of Tübingen
1990-1998
University of Geneva
1996
Saint Peter's University
1984
The cell surface receptor Fas (FasR, Apo-1, CD95) and its ligand (FasL) are mediators of apoptosis that have been shown to be implicated in the peripheral deletion autoimmune cells, activation-induced T death, one two major cytolytic pathways mediated by CD8+ cells. To gain further understanding system., we analyzed FasL expression during mouse development adult tissues. In developing embryos, from 16.5 d onwards, mRNA is detectable distinct types sinus, thymus, lung, liver, whereas...
The heat shock response (HSR) is a crucial biochemical pathway that orchestrates the resolution of inflammation, primarily under proteotoxic stress conditions. This process hinges on upregulation proteins (HSPs) and other chaperones, notably 70 kDa family proteins, command transcription factor-1. However, in context chronic degenerative disorders characterized by persistent low-grade inflammation (such as insulin resistance, obesity, type 2 diabetes, nonalcoholic fatty liver disease,...
Purpose: To compare the effects of a single high-intensity interval exercise session (HIIE) with moderate-intensity continuous (MICE) on inflammatory profile, IgA levels and lipid peroxidation in sedentary obese males. Methods: Ten men (age 28.5 ± 2.7 years; BMI 35.9 4.9 kg/m²; body fat 40.6 2.0%) performed three experimental sessions, separate days one week wash-out period between interventions, according to randomized order: 1) HIIE: 10 x 60 seconds at 90% HRmax alternated by active...
The heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger the HSR. This interplay between proteostasis regulation rooted fundamental need for ATP fuel protein synthesis repair, making HSR essential component of management. Recent findings suggest origins proteostasis-defending systems can be traced...
Ramis, TR, Muller, CHdL, Boeno, FP, Teixeira, BC, Rech, A, Pompermayer, MG, Medeiros, NdS, Oliveira, ÁRd, Pinto, RS, and Ribeiro, JL. Effects of traditional vascular restricted strength training program with equalized volume on isometric dynamic strength, muscle thickness, electromyographic activity, endothelial function adaptations in young adults. J Strength Cond Res 34(3): 689-698, 2020-The purpose the study was to evaluate compare acute chronic effects partial occlusion young, physically...
Effective resolution of inflammation via the heat shock response (HSR) is pivotal in averting transition to chronic inflammatory states. This characterizes a spectrum debilitating conditions, including insulin resistance, obesity, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular ailments. manuscript explores range physiological, pharmacological, nutraceutical interventions aimed at reinstating HSR context low-grade inflammation, as well protocols assess HSR. Monitoring...
Aims: We hypothesized that critically ill patients with SARS-CoV-2 infection and insulin resistance would present a reduced Heat Shock Response (HSR), which is pathway involved in proteostasis anti-inflammation, subsequently leading to worse outcomes higher inflammation. In this work we aimed: (i) measure the concentration of extracellular HSP72 (eHSP72) severe COVID-19 comparison noninfected patients; (ii) compare HSR between (with without diabetes); (iii) these individuals. Methods: Sixty...
Acute lymphoblastic leukemia (ALL) is associated with higher levels of pro-inflammatory cytokines and oxidative stress. Recently, the extracellular heat shock protein 72 (eHSP72) were found to be elevated in ALL, its elevation poor prognosis. Therefore, considering possible role eHSP72 as a modulator immunological system metabolism, aim this study was describe response induction phase chemotherapy, along metabolic, inflammatory stress markers, children adolescents newly diagnosed...
The aim of this study was to assess the effects an acute session resistance exercise with blood flow restriction in modulation oxidative stress parameters at different moments. Eleven participants (23.72 ± 3.49 years and 81.51 6.10 kg) were recruited perform a crossover design three protocols: high intensity (HI 80% 1RM), low (LI 30% (LI-BFR 1RM). profile four moments assessed: baseline, immediately after exercise, 24 48 hours later. Ethics Committee Methodist University Center-IPA (Porto...
This study examined the effects of hyperthermic therapy (HT) on mice fed normal chow or a high-fat diet (HFD) for 18 22 weeks, undergoing four eight weekly HT sessions. Mice were housed within their thermoneutral zone (TNZ) to simulate physiological response. HFD-induced obesity-related changes, including weight gain, visceral fat accumulation, muscle loss (indicative obesity sarcopenia), glucose intolerance, and hepatic triglyceride buildup. upregulated HSP70 expression in muscles,...
Chronic inflammatory diseases, e.g., obesity, cardiovascular disease, and type 2 diabetes, progressively suppress the anti-inflammatory heat shock response (HSR) by impairing synthesis of key components, perpetuating inflammation. Monitoring HSR progression offers predictive value for countering chronic This study quantified in high-fat diet (HFD) normal chow (NC) mice measuring 70 kDa protein (HSP70) expression after treatment whole blood samples. To align with human translational...
Being overweight is already considered a metabolic risk factor, which can be overcome by increasing cardiorespiratory fitness (CRF). Acute exercise known to induce changes in plasma hormones and heat shock proteins release. However, there lack of studies investigating the impact body composition CRF on these variables following acute aerobic exercise. To assess influence protein 72 kDa (HSP72), norepinephrine (NE), insulin, glucose responses an bout fed state. Twenty-four healthy male adults...