A5083260088- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Fetal and Pediatric Neurological Disorders
- Maternal and fetal healthcare
- Ectopic Pregnancy Diagnosis and Management
- Spinal Dysraphism and Malformations
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Urological Disorders and Treatments
- Reproductive Biology and Fertility
- Gestational Diabetes Research and Management
- Cerebrospinal fluid and hydrocephalus
- Ovarian function and disorders
- Lysosomal Storage Disorders Research
- Hernia repair and management
- Liver physiology and pathology
- Maternal and Perinatal Health Interventions
- Streptococcal Infections and Treatments
- Esophageal and GI Pathology
- Neonatal and fetal brain pathology
- Folate and B Vitamins Research
Rabin Medical Center
2019-2024
Tel Aviv University
2020-2024
Hadassah Medical Center
2009-2024
Hebrew University of Jerusalem
2015-2019
John Wiley & Sons (United Kingdom)
2019
Hudson Institute
2019
Harris Birthright Research Centre for Fetal Medicine
2011
King's College Hospital
2011
University of Cambridge
2010-2011
Hadassah Academic College
2000-2005
In Brief OBJECTIVE: The purpose of the study was to characterize perinatal outcome pregnancies complicated by placenta accreta. METHODS: We conducted a case-control analysis all deliveries between years 1990 and 2000 that were Perinatal variables included in gestational age at delivery, birth weight, Apgar scores, mortality. Statistical performed using both unpaired paired approach. P < .05 considered significant. RESULTS: encompassed 34,450 deliveries, from which 310 cases accreta diagnosed...
Background Mice, whose ribosomal protein S6 cannot be phosphorylated due to replacement of all five phosphorylatable serine residues by alanines (rpS6P−/−), are viable and fertile. However, phenotypic characterization these mice embryo fibroblasts derived from them, has established the role modifications in regulation size several cell types, as well pancreatic β-cell function glucose homeostasis. A relatively passive behavior raised possibility that they suffer muscle weakness, which has,...
Prenatal myelomeningocele (MMC) repair has significant advantages over postnatal repair, as was demonstrated by the Management of Myelomeningocele Study (MOMS) in 20111. This multicenter randomized controlled trial that prenatal compared with significantly reduced rate ventriculoperitoneal shunt placement first 12 months life and improved motor function, evidenced a higher proportion ambulatory infants at 30 months1. In MOMS, access to fetal spinal defect via laparotomy uterine...
A trial comparing prenatal with postnatal open spina bifida (OSB) repair established that surgery was associated better outcome. However, in the trial, fetal carried out through hysterotomy. Minimally invasive approaches are being developed to mitigate risks of maternal-fetal surgery. The objective this study investigate impact a novel neurosurgical technique for percutaneous fetoscopic OSB, skin-over-biocellulose antenatal (SAFER) technique, on long-term outcome.This examined descriptive...
Regenerative capacity is progressively lost with age. Here we show that pregnancy markedly improved liver regeneration in aged mice concomitantly inducing a switch from proliferation-based to regenerative process mediated by cell growth. We found the key mediator of this was Akt/mTORC1 pathway; its inhibition blocked hypertrophy, while increasing proliferation. Moreover, pharmacological activation pathway sufficed induce hypertrophy module, mimicking pregnancy. This treatment dramatically...
To determine if in fetuses with open spina bifida at 11-13 weeks' gestation there are alterations the cerebral ventricular system.In this study we selected 10 cases of and 410 normal singleton pregnancies which subsequently resulted delivery phenotypically neonates. In all transvaginal sonography was carried out three-dimensional (3D) brain volumes were acquired. The fetal head systematically assessed a series transverse views measurements obtained area lateral ventricles, diameter roof...
This study ascertained serum vitamin B12 levels among patients with Gaucher disease and healthy Israelis. Serum metabolites' were studied in consecutive adult not treated enzyme plus Ashkenazi Jewish neighbour-controls, together blood-donor volunteers of various ethnicities. Each group showed a high incidence low concentrations, 22.3% Jews 40% disease. These findings raise questions on the individual community B12. We recommend evaluation geographically contingent peoples.
Despite the prevalence of splenomegaly as a sign in many disorders, there have been no studies that correlate degree organomegaly with symptoms generally ascribed to splenic enlargement. The was compared five overt mechanical displacement, i.e. chronic abdominal pain, discomfort, early satiety, pain while lying on side, or attacks acute (colicky) left upper quadrant pains. We also employed seen Gaucher disease paradigm determine whether is correlation between and parameters hypersplenism....
Abstract Objective To determine possible differences in hepatic artery flow between trisomy 21 and euploid fetuses at 11–13 weeks' gestation. Methods Hepatic pulsatility index (PI) peak systolic velocity (PSV) were measured low risk of aneuploidies ( n = 350) another group high risk, including 283 47 with 21. The association PI PSV 21, fetal nuchal translucency (NT) thickness, tricuspid regurgitation, reversed a‐wave the ductus venosus was investigated. Results In low‐risk group, median 10.0...
Aging is characterized by reduced tissue regenerative capacity attributed to a diminished responsiveness of tissue-specific stem cells. With increasing age, resident precursor cells in muscle tissues show markedly impaired propensity proliferate response damage. However, exposure factors present the serum young mice restores aged As pregnancy represents unique biological model partially shared blood system between and old organisms, we hypothesized that would have rejuvenating effect on...
As a result of partial hepatectomy, the remaining liver tissue undergoes process renewed proliferation that leads to rapid regeneration liver. By following early stages this process, we observed dramatic programmed changes in DNA methylation profile, characterized by both de novo and demethylation events, with subsequent return original adult pattern as matures. Strikingly, these transient alterations partially mimic state embryonic hepatoblasts (E16.5), indicating hepatocytes actually...
Arterial embolisation is a recognised treatment for postpartum haemorrhage (PPH). In this retrospective study, we evaluate its use in the management of persistent PPH. Records all births during 54 month period at university hospital were analysed. Two sub‐groups identified. Group I ( n = 5), underwent after hysterectomy and II 4), had as first‐line theraphy without hysterectomy. Of 20,215 births, there 636 cases PPH (3.1%). Nine required to control bleeding (1.4%). needed multiple surgical...
Injury to muscle brings about the activation of stem cells, which then generate new myocytes replace damaged tissue. We demonstrate that this is accompanied by a dramatic change in stem-cell methylation pattern prepares them epigenetically for terminal myocyte differentiation. These de- and de novo events occur at regulatory elements associated with genes involved myogenesis are necessary regeneration. Local injury one elicits an almost identical epigenetic satellite cells from other muscles...