A5037312143- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Ginseng Biological Effects and Applications
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Nanoparticle-Based Drug Delivery
- Natural product bioactivities and synthesis
- Advanced Drug Delivery Systems
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Plant-derived Lignans Synthesis and Bioactivity
- Cannabis and Cannabinoid Research
- Plant-based Medicinal Research
- Drug-Induced Hepatotoxicity and Protection
- Ziziphus Jujuba Studies and Applications
- Flavonoids in Medical Research
- Bioactive Compounds and Antitumor Agents
- Drug Transport and Resistance Mechanisms
- Phytochemistry and biological activity of medicinal plants
- Traditional and Medicinal Uses of Annonaceae
- Saffron Plant Research Studies
- Ginger and Zingiberaceae research
- Geotechnical Engineering and Underground Structures
- Nanocomposite Films for Food Packaging
- Structural Integrity and Reliability Analysis
Jilin Medical University
2011-2025
South China Agricultural University
2023
Jilin University
2019-2020
Harbin University of Commerce
2017-2018
Ministry of Education of the People's Republic of China
2017
Tongji University
2017
Shenyang Pharmaceutical University
2014-2016
Nanchang Center for Disease Control and Prevention
2011
Abstract: Photothermal therapy (PTT) is widely regarded as a promising technology for cancer treatment. Gold nanorods (GNRs), excellent PTT agent candidates, have shown high-performance photothermal conversion ability under laser irradiation, yet two major obstacles to their clinical application are the lack of selective accumulation in target site following systemic administration and greatly reduced efficiency caused by self-aggregating aqueous environment. Herein, we demonstrate that...
Scorpion is a commonly used drug in traditional Chinese medicine for treating epilepsy, although the exact mechanisms are not yet fully understood. This study aimed to compare treatment effects of water extract (SWE) and ethanol (SEE) on mice with pentetrazole-induced epilepsy investigate possible through metabolomics methods. A epileptic model was assess corrective SWE SEE. Untargeted metabolomics, utilizing UPLC-Q-TOF/MS, employed analyze metabolic profiles identify changes following...
Zhi-Zi-Hou-Po decoction (ZZHPD), consisting of Gardenia jasminoides Ellis, Magnolia officinalis cortex and Citrus aurantium L., is a classic traditional Chinese medicine prescription for the treatment depression. However, therapeutic material foundation ZZHPD still not very clear. In present study, high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was developed to simultaneously characterize identify chemical constituents metabolites in...
ABSTRACT Huangqi Guizhi Wuwu Decoction (HGWD), a famous Chinese medicine prescription, has been widely used in the treatment of diabetic peripheral neuropathy and scleroderma China. Considering that decoction was not easy to store carry, our research group converted HGWD into Granules (HGWG) early stage. However, vivo metabolism profile HGWG still unclear. In this study, an ultra–high‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry (UHPLC‐Q‐TOF‐MS)...
Mercury (Hg) brings adverse effects to the environment and human beings inorganic mercury (IHg) is a typical hepatic toxin. This work studied impacts of IHg on gut microbes metabolome together with its damage liver in rats through microbiome, metabolomics metallomics. Sprague Dawley (SD) were orally exposed 0.4 μg/mL sacrificed after 24 h. It was found that perturbed greatly microbiota, such as increased pathogenic bacteria like G. bacillus. In addition, also changed gut-liver axis related...
A sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry method was established to separate identify the chemical constituents of Zhi–Zi–Da–Huang decoction, a classic traditional Chinese medicine formula. The chromatographic separation achieved on Shim‐pack XR‐ODS C 18 column (75 × 3.0 mm, 2.2 μm) using gradient elution program. detection performed Waters Xevo G2 Q‐TOF spectrometer equipped electrospray ionization source...
Among the various ginseng strains, Shizhu is endemic to China, mainly distributed in Kuandian Manchu Autonomous County (Liaoning Province, China); however, not much known about compounds (especially saponins) ginseng. A rapid, sensitive, and reliable ultra-high performance liquid chromatography coupled with MS/MS (UHPLC–MS/MS) method was developed separate identify saponins The separation carried out on a Waters ACQUITY UPLC BEH C18 column (100 mm × 2.1 mm, 1.7 μm) acetonitrile 0.1% formic...
Radix Gentianae is a traditional Chinese medicine derived from medicinal plants of the family Gentianaceae. Its pharmacological effects have been primarily attributed to presence number secoiridoid glycosides, in particular gentiopicroside and swertiamarin. In this study, rapid sensitive method based on ultrafast liquid chromatography-tandem mass spectrometry has developed for simultaneous determination swertiamarin rat plasma using paeoniflorin as internal standard (IS).After liquid-liquid...
Abstract Zhi‐Zi‐Hou‐Po Decoction, consisting of Gardenia jasminoides Ellis, Magnolia officinalis Rehd. et Wils., and Citrus aurantium L, is a classical Traditional Chinese Medicine formula for the treatment depression. In order to make good rational use this in future, sensitive, selective, reliable ultra high performance liquid chromatography with tandem mass spectrometry method was developed simultaneous determination two iridoid glycosides (geniposide genipin gentiobioside), lignans...
Mitomycin C (MTC) was incorporated to a micelle system preparing from polymer named deoxycholic acid chitosan-grafted poly(ethylene glycol) methyl ether (mPEG-CS-DA). mPEG-CS-DA synthesized and characterized by (1)H nuclear magnetic resonance ((1)H-NMR) Fourier transform infrared spectroscopy. formed core-shell micellar structure with critical concentration of 6.57 µg/mL. The micelles were spherical hydrodynamic diameter about 231 nm. After glycol)ylation chitosan (CS-DA), the encapsulation...
Abstract Tianshu Capsule, consisting of Ligusticum chuanxiong Hort and Gastrodia elata Blume, is a widely used Traditional Chinese Medicine preparation for the treatment migraine. Ferulic acid gastrodin are main active constituents in have been as marker components quality control Capsule. In this study, selective, sensitive, reliable ultra‐fast liquid chromatography with tandem mass spectrometry method was developed simultaneous determination ferulic rat plasma using geniposide internal...
Abstract A rapid, selective, and sensitive ultra‐high performance liquid chromatography‐tandem mass spectrometry method was developed for simultaneous determination of ferulic acid, paeoniflorin, albiflorin, the major active constituents Danggui‐Shaoyao‐San, in rat plasma using geniposide as internal standard. The samples were processed by protein precipitation with acetonitrile, then separated on a Shim‐Pack XR‐ODS C 18 column (75 mm × 3.0 mm, 2.2 μm) gradient elution program mobile phase...
Abstract Zhi‐Zi‐Da‐Huang decoction (ZZDHD), a classical traditional Chinese medicine (TCM) prescription composed of four herbal medicines, has been widely used in treating various hepatobiliary disorders for long time. The objective this study was to develop sensitive and efficient liquid chromatography coupled with mass spectrometry (LC‐MS) method quantitative determination 20 active constituents, including three iridoid glycosides, 11 flavonoids, anthraquinones tannins ZZDHD. Separation...