A5032004334- Gut microbiota and health
- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Asthma and respiratory diseases
- Biochemical Analysis and Sensing Techniques
- Eosinophilic Disorders and Syndromes
- Receptor Mechanisms and Signaling
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
Utrecht University
2021-2023
Karolinska University Hospital
2023
Karolinska Institutet
2023
Mast cells (MCs) accumulate in the epithelium of patients with eosinophilic esophagitis (EoE), an inflammatory disorder characterized by extensive esophageal infiltration. Esophageal barrier dysfunction plays important role pathophysiology EoE. We hypothesized that MCs contribute to observed impaired epithelial barrier. Herein, we demonstrate coculture differentiated immunoglobulin E-activated significanly decreased resistance 30% and increased permeability 22% compared non-activated MCs....
The authors declare no conflicts of interest.