Carlos Saraiva-Garcia

ORCID: 0000-0003-0224-9734
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About
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Research Areas
  • Antibiotic Resistance in Bacteria
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Vibrio bacteria research studies
  • Antibiotic Use and Resistance
  • Malaria Research and Control
  • Salivary Gland Disorders and Functions
  • Oral microbiology and periodontitis research
  • Insect and Pesticide Research
  • Oral Health Pathology and Treatment
  • Toxin Mechanisms and Immunotoxins
  • Child Nutrition and Water Access
  • Insect and Arachnid Ecology and Behavior
  • Aquaculture disease management and microbiota
  • Signaling Pathways in Disease
  • Toxoplasma gondii Research Studies
  • Immune Response and Inflammation
  • Antimicrobial Peptides and Activities
  • Gut microbiota and health
  • Vaccine Coverage and Hesitancy
  • S100 Proteins and Annexins
  • Bone health and treatments
  • Research on Leishmaniasis Studies
  • Invertebrate Immune Response Mechanisms
  • Periodontal Regeneration and Treatments
  • Oral and Maxillofacial Pathology

Universidad San Francisco de Quito
2020-2023

Universidade de Brasília
2009-2023

Molécules de Communication et Adaptation des Micro-organismes
2017-2021

Centre National de la Recherche Scientifique
2017-2021

Sorbonne Université
2017

Universidade Federal do Rio de Janeiro
2010-2016

Muséum national d'Histoire naturelle
2016

University of Southern Denmark
2012

Universidade Federal de Uberlândia
2009

There is a significant gap in our understanding of the sources multidrug-resistant bacteria and resistance genes community settings where human-animal interfaces exist.This study characterized relationship third-generation cephalosporin-resistant Escherichia coli (3GCR-EC) isolated from animal feces environment child based on phenotypic antimicrobial (AMR) whole genome sequencing (WGS).We examined 3GCR-EC environmental fecal samples domestic animals Ecuador. We analyzed genotypic AMR, as...

10.1289/ehp7729 article EN public-domain Environmental Health Perspectives 2021-02-01

The honey bee (Apis mellifera) is a social insect that shows complex and integrated behaviors. Its ability to read respond several sets of extrinsic intrinsic signals fundamental for the modulation individual activities systems. For instance, A. mellifera behavior changes upon ontogenetic differentiation from nurse forager worker subcastes. In this work, brain proteomes nurses foragers were compared by two-dimensional gel electrophoresis within pH range 4−7 in order find proteins related...

10.1021/pr800823r article EN Journal of Proteome Research 2009-02-09

Gonçalves L da R, Soares MR, Nogueira FCS, Garcia CHS, Camisasca DR, Domont G, Feitosa ACR, Pereira DA, Zingali RB, Alves G. Analysis of the salivary proteome in gingivitis patients. J Periodont Res 2011; 46: 599–606.©2011 John Wiley & Sons A/S Background and Objective: Gingivitis is a disease that characterized by inflammation gingival tissue, which can progress to periodontitis tooth loss. Although many studies have attempted identify proteins are associated with disease, this first study...

10.1111/j.1600-0765.2011.01378.x article EN Journal of Periodontal Research 2011-06-01

Background The spread of antibiotic-resistant bacteria may be driven by human–animal–environment interactions, especially in regions with limited restrictions on antibiotic use, widespread food animal production, and free-roaming domestic animals. In this study, we aimed to identify risk factors related commercial small-scale or “backyard” ownership, practices handling, waste disposal, use Ecuadorian communities. Methods findings We conducted a repeated measures study from 2018 2021 7...

10.1371/journal.pmed.1004299 article EN cc-by PLoS Medicine 2023-10-13

Extended-spectrum β-lactamase (ESBL)-producing and other antimicrobial resistant (AR) Escherichia coli threaten human animal health worldwide. This study examined risk factors for domestic colonization with ceftriaxone-resistant (CR) ESBL-producing E . in semirural parishes east of Quito, Ecuador, where small-scale food production is common. Survey data regarding household characteristics, care, use were collected from 304 households over three sampling cycles, 1195 environmental fecal...

10.1371/journal.pgph.0000206 article EN cc-by PLOS Global Public Health 2022-03-23

Background: Neutrophils have an impressive array of microbicidal weapons, and in the presence a pathogen, progress from quiescent state bloodstream to completely activated state. Failure regulate this activation, for example, when blood is flooded with cytokines after severe trauma, causes inappropriate neutrophil activation that paradoxically, associated tissue organ damage. Acidic proteomic maps human neutrophils were analyzed compared those trauma patients. The analysis revealed 114 spots...

10.2174/092986612800493977 article EN Protein and Peptide Letters 2012-04-01

Small-scale food animal production has been celebrated as a means of economic mobility and improved security but the use veterinary antibiotics among these producers may be contributing to spread antibiotic resistance in animals humans. In order improve stewardship this sector, it is critical identify drivers producers’ use. This study assessed determinants small-scale through simulated client visits supply stores surveys with households that owned (n = 117) Ecuador. Eighty percent chickens...

10.3390/antibiotics10010002 article EN cc-by Antibiotics 2020-12-23

The coronavirus 2019 (COVID-19) pandemic has had significant impacts on health systems, population dynamics, public awareness, and antibiotic stewardship, which could affect resistant bacteria (ARB) emergence transmission. In this study, we aimed to compare knowledge, attitudes, practices (KAP) of use ARB carriage in Ecuadorian communities before versus after the COVID-19 began. We leveraged data collected for a repeated measures observational study third-generation cephalosporin-resistant...

10.1038/s41598-023-39532-5 article EN cc-by Scientific Reports 2023-09-08

Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL), a family of bacteria that includes Escherichia coli, have emerged as global health threat. This study examined risks associated with carriage third-generation cephalosporin-resistant (3GC-R) E. including ESBL-producing, multidrug-resistant, and extensively drug-resistant (XDR) strains in children living semirural parishes Quito, Ecuador. We conducted longitudinal two cycles sampling (N = 374, N 366) included an analysis...

10.4269/ajtmh.20-0532 article EN American Journal of Tropical Medicine and Hygiene 2021-07-19

Abstract Background The rapid spread of extended-spectrum beta-lactamase-producing E. coli (ESBL-EC) is an urgent global health threat. We examined child caretaker knowledge, attitudes, and practices (KAP) towards proper antimicrobial agent use whether certain KAP were associated with ESBL-EC colonization their children. Methods Child caretakers living in semi-rural neighborhoods peri-urban Quito, Ecuador visited surveyed about antibiotics. Fecal samples from one (less than 5 years age) per...

10.1186/s13756-020-00867-7 article EN cc-by Antimicrobial Resistance and Infection Control 2021-01-06

Learning to anticipate events based on the predictive relationship between an action and outcome (operant conditioning) is a form of associative learning shared by humans most other living beings, including invertebrates. Several behavioral studies mechanisms operant conditioning have included Melipona quadrifasciata, honey bee that easily manipulated due lack sting. In this work, brain proteomes bees trained using untrained (control) were compared two-dimensional gel electrophoresis...

10.1590/0001-3765202320201317 article EN cc-by Anais da Academia Brasileira de Ciências 2023-01-01

Abstract Background The spread of antibiotic-resistant bacteria may be driven by human-animal-environment interactions, especially in regions with limited restrictions on antibiotic use, widespread food animal production, and free-roaming domestic animals. In this study, we aimed to identify risk factors related animals, backyard commercial production Ecuadorian communities. Methods & Findings We conducted a repeated-measures study from 2018-2021 7 semi-rural parishes Quito, Ecuador...

10.1101/2022.11.14.22282279 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2022-11-14

Background: The gut microbiota is a source of diverse set antimicrobial resistance genes (ARGs), and little known about the temporal dynamics resistome over time. Methods: In present repeated measures study, we characterized children’s according to sampling periods age. From cohort 29 children ages three months 7 years old, obtained 104 fecal samples (range: 3 5 per child for years). Findings: relative abundance ARGs within each child’s sample varied We observed transitory elevations some...

10.2139/ssrn.4519560 preprint EN 2023-01-01
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