A. Mazzone
A5040236189- Nuclear Physics and Applications
- Nuclear reactor physics and engineering
- Nuclear physics research studies
- Radiation Detection and Scintillator Technologies
- Advanced Chemical Physics Studies
- ZnO doping and properties
- Surface and Thin Film Phenomena
- Molecular Junctions and Nanostructures
- Gas Sensing Nanomaterials and Sensors
- Enzyme Structure and Function
- Semiconductor materials and interfaces
- Radiation Therapy and Dosimetry
- X-ray Diffraction in Crystallography
- nanoparticles nucleation surface interactions
- Particle physics theoretical and experimental studies
- Ion-surface interactions and analysis
- Nuclear Materials and Properties
- Nanowire Synthesis and Applications
- Particle Detector Development and Performance
- Graphene research and applications
- Astro and Planetary Science
- Immune Cell Function and Interaction
- Silicon and Solar Cell Technologies
- Electron and X-Ray Spectroscopy Techniques
- Chemical and Physical Properties of Materials
Istituto Nazionale di Fisica Nucleare, Sezione di Bari
2016-2024
Consorzio Roma Ricerche
2017-2024
Istituto Nazionale di Fisica Nucleare
2019-2024
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2024
Universidad Complutense de Madrid
2024
Institute of Crystallography
2012-2023
National Research Council
2009-2023
Azienda Ospedaliera S.Giuseppe Moscati
2018-2023
Istituto Nazionale di Fisica Nucleare, Sezione di Trieste
2023
National Agency for New Technologies, Energy and Sustainable Economic Development
2023
SIR2014 is the latest program of SIR suite for crystal structure solution small, medium and large structures. A variety phasing algorithms have been implemented, both ab initio (standard or modern direct methods, Patterson techniques, Vive la Différence ) non- (simulated annealing, molecular replacement). The contains tools refinement study three-dimensional electron-density maps via suitable viewers.
SIR2011 , the successor of SIR2004 is latest program SIR suite. It can solve ab initio crystal structures small- and medium-size molecules, as well protein structures, using X-ray or electron diffraction data. With respect to predecessor has several new abilities: e.g. a phasing method (VLD) been implemented, it able exploit prior knowledge molecular geometry via simulated annealing techniques, use replacement methods for solving proteins, includes tools like free lunch approaches data,...
The energy-dependent cross section of the ^{7}Be(n,α)^{4}He reaction, interest for so-called cosmological lithium problem in big bang nucleosynthesis, has been measured first time from 10 meV to keV neutron energy. challenges posed by short half-life ^{7}Be and low reaction have overcome at n_TOF thanks an unprecedented combination extremely high luminosity good resolution beam new experimental area (EAR2) facility CERN, availability a sufficient amount chemically pure ^{7}Be, specifically...
Abstract Aims Frailty is common in patients with atrial fibrillation (AF), possible impact on therapies and outcomes. However, definitions of frailty are variable, may not overlap perception among physicians. We evaluated the prevalence as perceived by enrolling physicians Edoxaban Treatment Routine Clinical Practice for Patients With Non-Valvular AF (ETNA-AF)-Europe registry (NCT02944019), compared it an objective assessment. Methods results ETNA-AF-Europe a prospective, multi-centre,...
A combination of three beta, or C-C, chemokines, as well IL-16, have been shown to inhibit HIV replication in vitro. Cellular antiviral factor is a more potent agent, and acts on all strains. All are mainly, but not exclusively, produced by CD8+ T cells, both HIV+ healthy subjects. We studied the production these HIV-suppressive factors patients with infection at different stages disease. No difference PBMC stimulated PHA has observed asymptomatic HIV+, long-term nonprogressors (LTnP), AIDS...
SUNBIM (supramolecular and submolecular nano- biomaterials X-ray imaging) is a suite of integrated programs which, through user-friendly graphical user interface, are optimized to perform the following: (i) q -scale calibration two-dimensional → one-dimensional folding on small- wide-angle scattering (SAXS/WAXS) grazing-incidence SAXS/WAXS (GISAXS/GIWAXS) data, also including possible eccentricity corrections for WAXS/GIWAXS data; (ii) background evaluation subtraction, denoising,...
Abstract This article presents a few selected developments and future ideas related to the measurement of $$(n,\gamma )$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>n</mml:mi> <mml:mo>,</mml:mo> <mml:mi>γ</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> </mml:math> data astrophysical interest at CERN n_TOF. The MC-aided analysis methodology for use low-efficiency radiation detectors in time-of-flight neutron-capture measurements is discussed, with...
Abstract Acrylonitrile‐butadiene‐styrene (ABS) based composites with a high content of tungsten and bismuth oxide were developed using an innovative process to obtain lead‐free x‐ray shielding materials. ABS was chosen for its good mechanical properties widespread availability as recycled material. The underwent flexural tests, Shore D hardness thermogravimetric morphological analysis, their attenuation determined through numerical simulations experimental measurements. Despite filler (up 75...
The neutron time-of-flight facility n_TOF at CERN is a spallation source dedicated to measurements of neutron-induced reaction cross-sections interest in nuclear technologies, astrophysics, and other applications. Since 2014, Experimental ARea 2 (EAR2) operational delivers fluence ∼4⋅107 neutrons per nominal proton pulse, which ∼50 times higher than the one 1 (EAR1) ∼8⋅105 pulse. high flux EAR2 results counting rates detectors that challenged previously existing capture detection systems....
^{140}Ce(n,γ) is a key reaction for slow neutron-capture (s-process) nucleosynthesis due to being bottleneck in the flow. For this reason, it was measured with high accuracy (uncertainty ≈5%) at n_TOF facility, an unprecedented combination of purity sample and low neutron-sensitivity detectors. The Maxwellian averaged cross section up 40% higher than previously accepted values. Stellar model calculations indicate reduction around 20% s-process contribution Galactic cerium abundance smaller...
Abstract In patients with primary Ab deficiencies, hematological and immunological abnormalities are frequently observed. A regenerative failure of hemopoietic stem/progenitor cells has been hypothesized. We evaluated in the bone marrow (BM) 11 common variable immunodeficiency, phenotype BM progenitors their vitro growth by colony-forming cell (CFC) long-term culture (LTC) assays. significant decrease erythroid mixed CFC and, to a greater extent, primitive LTC-CFC was observed compared...
Rheumatoid arthritis (RA) patients are characterized by increased arterial stiffness, an independent predictor of cardiovascular risk. It has been suggested that osteopontin (OPN), a cytokine involved in RA pathogenesis, might have vascular effects. To study possible relationship between OPN and aortic pulse wave velocity (PWV) was measured tonometry 69 (41 with RA, 28 systemic sclerosis (SSc)) 18 healthy controls. Plasma levels, oxidative stress markers, endothelin 1 (ET-1) were assessed....
Nuclear data in general, and neutron-induced reaction cross sections particular, are important for a wide variety of research fields. They play key role the safety criticality assessment nuclear technology, not only existing power reactors but also radiation dosimetry, medical applications, transmutation waste, accelerator-driven systems, fuel cycle investigations future reactor systems as Generation IV. Applications related to fields study level densities stellar nucleosynthesis....
Organic capped Au nanoparticles (NPs) and PbS quantum dots (QDs), synthesized with high control on size distribution, were used as building blocks for fabricating solid crystals by solvent evaporation. The superlattice formation process the two types of nano-objects was investigated a function concentration means electron microscopy X-ray techniques. effect block composition, size, geometry, role organic coordinating molecules related to degree order in superlattices. A convenient...
The newly built second experimental area EAR2 of the n_TOF spallation neutron source at CERN allows to perform (n, charged particles) experiments on short-lived highly radioactive targets. This paper describes a detection apparatus and procedure for determination cross-section 7Be(n,α)α reaction, which represents one focal points toward solution cosmological Lithium abundance problem, whose only measurement, thermal energy, dates back 1963. apparently unsurmountable difficulties stemming...
One of the critical aspects for accurate determination neutron capture cross sections when combining time-of-flight and total energy detector techniques is characterization control systematic uncertainties associated to measuring devices. In this work we explore most conspicuous effects harsh count rate conditions: dead-time pile-up effects. Both effects, not properly treated, can lead large bias in sections. majority measurements carried out at CERN n_TOF facility, detectors choice are C6D6...
In this study we investigate the redox profile of HIV+ patients at different stages disease with regard to immunological parameters, i.e., number circulating CD4+ and CD8+ lymphocytes. For purpose, peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, in asymptomatic phase, long-term nonProgressors (LTNPs), AIDS have been considered. Cells exposed vitro prooxidizing agent menadione, which is able induce superoxide anion formation, susceptibility induced oxidative stress...
The success of the ab initio phasing process mainly depends on two parameters: data resolution and structural complexity. In agreement with Sheldrick rule, presence heavy atoms can also play a nonnegligible role in direct methods. increased efficiency Patterson methods advent new techniques based extrapolated reflections have changed state art. particular, it is not clear how much limit complexity may be pushed atoms. this paper, shown that limits fixed by rule relaxed if structure contains...
Following the completion of second neutron beam line and related experimental area (EAR2) at n_TOF spallation source CERN, several experiments were planned performed. The high instantaneous flux available in EAR2 allows to investigate induced reactions with charged particles exit channel even employing targets made out small amounts short-lived radioactive isotopes. After successful measurement 7Be(n,α)α cross section, 7Be(n,p)7Li reaction was studied order provide still missing section data...
BEAM (carmustine [bis-chloroethylnitrosourea (BCNU)]-etoposide-cytarabine-melphalan) chemotherapy is the standard conditioning regimen for autologous stem cell transplantation (ASCT) in lymphomas. Owing to BCNU shortages, many centers switched fotemustine-substituted (FEAM), lacking proof of equivalence. We conducted a retrospective cohort study 18 Italian compare safety and efficacy FEAM regimens ASCT lymphomas performed from 2008 2015. enrolled 1038 patients (BEAM = 607, 431), which 27%...
The method of joint probability distribution functions has been applied to molecular replacement techniques. rotational search is performed by rotating the reciprocal lattice protein with respect calculated transform model structure; translation fast Fourier transform. Several cases prior information are studied, both for rotation and step: e.g. conditional density or a monomer found ab initio when and/or values other monomers given. new approach implemented in program REMO09, which part...