BACKGROUND: Clarithromycin is an antimicrobial agent that can be used for treatment of chronic obstructive pulmonary disease (COPD) exacerbations with bronchodilator therapy. However, it has also been shown clarithromycin antiinflammatory effects by the inhibition cytokine production. OBJECTIVE: To evaluate effect on serum and sputum interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), leukotriene B 4 levels in patients COPD. METHODS: Thirty men mild to moderate COPD were enrolled this...

Although both inhaled and oral corticosteroids have anti-inflammatory effects causing improvement in clinical symptoms spirometry the treatment of asthma, role management chronic obstructive pulmonary disease (COPD) is controversial.To evaluate on sputum neutrophilia clinically stable COPD patients.In total, 18 patients were enrolled study. During 2 months, 9 group A fluticasone propionate (FP) 500 microg 3 times daily. In B received placebo. All continued to inhale salbutamol ipratropium...

The aim of the study was to evaluate role diffusion-weighted magnetic resonance imaging in differential diagnosis lung lesions. PATIENTS AND METHODS.: Sixty-seven patients with lesions (48 malignant, 19 benign) were included this prospective study. Signal intensities (SIs) measured MR images that obtained b=0, 500 and 1000 s/mm(2) values. Apparent diffusion coefficient (ADC) maps calculated by using b=0 statistical significance determined Student-t test.The SIs malignant significantly higher...

Heat shock proteins (HSPs) are expressed by most living cells and play fundamental roles in many biological processes. Their synthesis increases a variety of stresses order to enable cellular survival. Although it is known that they an important role immune inflammatory responses the skin, HSPs pathogenesis skin diseases has been studied only limited diseases. Lichen planus (LP) relatively common papulosquamous dermatosis, cell-mediated immunity plays its pathogenesis. altered expression...

To determine induced sputum cell counts and interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-alpha) leukotriene B4 (LTB4) levels as markers of neutrophilic inflammation in moderate persistent asthma, to evaluate the response inhaled steroid therapy.Forty-five asthmatic patients 10 non-smoker controls were included this study. All received corticosteroid (800 microg budesonide) for 12 weeks. Before after treatment pulmonary function tests performed, symptom scores determined. Blood was...

Research Articles| February 18 2011 Clinicopathologic Significance of Eosinophilic Pleural Effusions in a Population with High Prevalence Tuberculosis and Cancer Topic Article Package: Respiratory System 2019 Subject Area: Pathology Cell Biology Sevgiye Kaçar Özkara; Özkara From Kocaeli University, Faculty Medicine, Departments Chest Diseases, Kocaeli, Turkey. Search for other works by this author on: This Site PubMed Google Scholar Gupse Turan; Turan Ilknur Başyiğit Acta Cytologica (2007)...

Appropriate clinical management of a hepatic mass depends on its accurate diagnosis. We aimed to evaluate sensitivity, specificity and accuracy percutaneous fine needle aspiration cytopathology (FNAC) in the diagnosis suspicious liver masses our center.Cytopathology histopathology databases were searched for patients undergoing combined, image-guided FNAC biopsy sampling lesions 2006-2011. All had one or more radiologically detected lesion suspicion neoplastic disease. Sensitivity,...

The author evaluated a consecutive group of peritoneal washings (PWs) performed in the evaluation adnexal masses to determine whether conventional histopathologic prognostic parameters significantly affect tumor detection rate using this procedure.Cytopathologic reports from all PWs over 13-year (1996-2008) period malignant and borderline ovarian tumors were reviewed correlated with those synchronously obtained specimens. Tumors low potential (LMP) separated for analysis. Statistical...

Adenoid cystic carcinoma (ACC) is a rare, distinctive salivary gland malignant neoplasm arising infrequently as primary tumor in the lung. Cytomorphology of lung ACC has been rarely reported. To best our knowledge, cytopathologic features solid type have not described tumor.A case solid-type pulmonary upper segment left mainstem bronchus, suggestively diagnosed cytopathologically by bronchoscope-guided fine needle aspiration (FNA), presented. Cytopathologic differential diagnoses with other,...

Research Articles| March 02 2011 The Gray Zone in Breast Fine Needle Aspiration Cytology: How to Report on it? Topic Article Package: Cytology Subject Area: Pathology and Cell Biology Sevgiye Kaçar Özkara; Özkara From the Department of Pathology, Faculty Medicine, University Kocaeli, Citographica Cyto-Pathology Diagnostic Lab, İzmit, Turkey. Search for other works by this author on: This Site PubMed Google Scholar Melek Özkal Üstün; Üstün Nadir Paksoy Acta Cytologica (2002) 46 (3): 513–518....

Objectives: Inhaled corticosteroids, leukotriene receptor antagonists, and theophylline are recommended for the treatment of mild persistent asthma. The aim this study was to compare changes in sputum total cell eosinophil counts, cationic protein (ECP) levels serum following with inhaled patients Methodology: Total percentage, ECP induced were determined both before after treatment. Prior induction, FEV 1 PEF values symptom scores recorded at baseline 8 weeks After measurements, asthmatic (...

Cystadenofibromas of the fallopian tube are rare tumors female genital tract. These usually asymptomatic and found incidentally. The authors present an incidentally serous cystadenofibroma in a 48-year-old woman with leiomyoma uteri. topographic localization lesion, histopathologic findings müllerian-type epithelium, immunophenotypic profile vimentin-cytokeratin coexpression, diffuse apical epithelial membrane antigen (EMA) immunoreactivity suggested that tumor was embryologic remnant...

Case Reports| February 15 2011 Cystic Fluid and Fine Needle Aspiration Cytopathology of Adult Granulosa Cell Tumor the Ovary: A Report Subject Area: Pathology Biology Sevgiye Kaçar Özkara; Özkara From Department Pathology, Faculty Medicine, Kocaeli University, Gebze, Kocaeli, Turkey. Search for other works by this author on: This Site PubMed Google Scholar Gupse Turan Acta Cytologica (2008) 52 (2): 247–250. https://doi.org/10.1159/000325492 Article history Published Online: Content Tools...

We report a case of solitary calcaneal metastasis in patient with superficial bladder carcinoma. The underwent transurethral tumor resection twice because local recurrence. Both histologic examinations revealed grade 2 PT1 transitional cell carcinoma the bladder. was detected four months after initial cystoscopy, due to severe leg pain. lesion curetted and filled bone cement. A year later, below knee amputation performed This deserves special attention, for two reasons. First, metastatic...

Fragile histidine triad (FHIT), a candidate of tumor suppressor protein, expression was examined on paraffin-embedded specimens in proliferative, secretory, hyperplastic, and neoplastic human endometrium by immunohistochemistry. The results FHIT immunoreactivity endometrial carcinomas were compared with prognostic indicators as well p53 overexpression. Forty-four cases carcinoma, 30 normal functional (15 15 secretory), 24 hyperplastic (12 without atypia, 12 atypia) studied using polyclonal...