A5012207029- Immune cells in cancer
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- Cancer Immunotherapy and Biomarkers
- Connexins and lens biology
- interferon and immune responses
- Probiotics and Fermented Foods
- Amoebic Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Ion Channels and Receptors
- Calcium signaling and nucleotide metabolism
- RNA modifications and cancer
- Eicosanoids and Hypertension Pharmacology
- Pediatric health and respiratory diseases
- Adenosine and Purinergic Signaling
- ATP Synthase and ATPases Research
- Gut microbiota and health
- Cytomegalovirus and herpesvirus research
- Toxoplasma gondii Research Studies
- Heat shock proteins research
- Adipokines, Inflammation, and Metabolic Diseases
- Infectious Diseases and Tuberculosis
The Ohio State University Wexner Medical Center
2024
The Ohio State University
2024
Lung Institute
2024
International Centre for Genetic Engineering and Biotechnology
2022-2024
University of Delhi
2015-2023
Ambedkar University Delhi
2015
Pathogen-associated molecular patterns (PAMPs) like bacterial cell wall components and viral nucleic acids are known ligands of innate inflammatory receptors that trigger multiple pathways may result in acute inflammation oxidative stress-driven tissue organ toxicity. When dysregulated, this lead to toxicity multiorgan failure. Inflammatory events often driven by high energy demands macromolecular biosynthesis. Therefore, we proposed targeting the metabolism lipopolysaccharide (LPS)-driven...
We previously reported that M. tb on its own as well together with HIV inhibits macrophage apoptosis by upregulating the expression of Bcl2 and Inhibitor Apoptosis (IAP). In addition, recent reports from our lab showed stimulation either macrophages or BMDCs results in significant upregulation Bcl2. this report, we delineate role mediating defense responses dendritic cells (BMDCs) during mycobacterial infection. Inhibiting led to a decrease intracellular bacterial burden BMDCs. To further...
Staphylococcus aureus (S. aureus) is a gram-positive bacteria, which causes various fatal respiratory infections including pneumonia. The emergence of Methicillin-Resistance (MRSA) demands thorough understanding host-pathogen interactions. Here we report the role calcium in regulating defence responses S. macrophages. Regulating fluxes cells by different routes differentially governs expression T cell costimulatory molecule CD80 and Th1 promoting IL-12 receptor. Inhibiting influx from...
Post translational modifications (PTMs) are exploited by various pathogens in order to escape host immune responses. SUMOylation is one of the PTMs which involved regulation a variety cellular However, effects on pathogenic bacteria largely remain elusive. We, therefore, investigated role regulating defense responses dendritic cells (DCs) during mycobacterial infection. Dendritic Cells female BALB/c mice and THP-1 macrophages were used. Western blotting was performed measure expression level...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Verma C, Swami B, Upadhyay V, et al. Tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome in HIV: immunological review of manifestation immunopathogenesis. HIV & AIDS Review. International Journal HIV-Related Problems. 2020;19(2):67-73. doi:10.5114/hivar.2020.96486. APA Verma, C., Swami, B., Upadhyay, V., Singh, A., Anang, Saraswati, S. (2020). Problems, 19(2), 67-73....
Abstract Pathogen-associated molecular patterns (PAMPs) associated with viral and bacterial infections trigger multiple inflammatory pathways which may result in oxidative stress driven toxicity, tissue fibrosis organ dysfunction ageing. Inflammatory events need high energy demands predominantly depends on the glycolysis. Thus, metabolism of can be targeted to reducing magnitude PAMPs inflammation preventing toxicity. Here we propose that 2-DG, a glycolytic inhibitor, potential Energy...
Abstract Inflammation is a critical component and contributor of carcinogenesis. Toll like receptors (TLRs) are key regulators innate immunity inflammatory signaling. Besides various microbe-associated molecular patterns, TLRs can also bind to endogenously generated damage associated patterns (DAMPS) ligands such as heat shock proteins, surfactant protein A18 homobility group box-1(HMGB1). While HMGB1, TLR-4 ligand over-expressed in several human neoplasms, preclinical studies mouse tumor...