A5015352789- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Natural Antidiabetic Agents Studies
- Natural product bioactivities and synthesis
- COVID-19 and Mental Health
- Phytochemicals and Antioxidant Activities
- Ethnobotanical and Medicinal Plants Studies
- Pharmacological Effects of Natural Compounds
- Quantum Dots Synthesis And Properties
- Essential Oils and Antimicrobial Activity
- Microbial Metabolism and Applications
- Chalcogenide Semiconductor Thin Films
- Copper-based nanomaterials and applications
- Psidium guajava Extracts and Applications
- Alkaloids: synthesis and pharmacology
- Garlic and Onion Studies
- Chemistry and Chemical Engineering
- Chemical Synthesis and Analysis
- Toxin Mechanisms and Immunotoxins
- Biological Activity of Diterpenoids and Biflavonoids
- Infectious Diseases and Mycology
- Marine Sponges and Natural Products
- Plant-Microbe Interactions and Immunity
- Technology-Enhanced Education Studies
- Gout, Hyperuricemia, Uric Acid
Texas Tech University
2024
Tribhuvan University
2019-2023
Abstract Background Hypercholesterolemia has posed a serious threat of heart diseases and stroke worldwide. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid biosynthesis, is regarded as root reactive oxygen species (ROS) that generate atherosclerosis cholesterol crystals. β-Hydroxy β-methylglutaryl-coenzyme A reductase (HMGR) biosynthesis. Although some commercially available inhibiting drugs have effectively reduced levels, most them failed to meet potential drug candidates’...
Acacia catechu (L.f.) Willd is a profoundly used traditional medicinal plant in Asia. Previous studies conducted this are more confined to extract level. Even though bioassay-based indicated the true therapeutic potential of plant, compound annotation was not performed extensively. This research aimed at assessing bioactivity different solvent extracts followed by its phytoconstituents. Liquid chromatography equipped with high resolution mass spectrometry (LC-HRMS) deployed for...
Streptomyces are widely used for the production of secondary metabolites with diverse biological activities, including antibiotics. The necessity alternative antimicrobial agents against multidrug-resistant pathogens is indispensable. However, new therapeutics delayed in recent days. Thus, isolation species has drawn attention. Nepal—a country rich biodiversity—has got high possibilities discovery members actinomycetes, especially higher altitudes. vain, only a few screening research works...
Natural products have been the center of attraction ever since they were discovered. Among them, plant-based natural popular as analgesics, anti-inflammatory, antidiabetic, and cosmetics possess widespread biotechnological applications. The use plant therapeutics is deep-rooted in Nepalese society. Although there are few ethnobotanical studies conducted, extensive research these valuable medicinal plants has not a priority due to limitation technology infrastructure. Here, we selected 4...
Finding new antibacterial agents from natural products is urgently necessary to address the growing cases of antibiotic-resistant pathogens. Actinomycetes are regarded as an excellent source therapeutically important secondary metabolites including antibiotics. However, they have not yet been characterized and explored in great detail for their utility developing countries such Nepal. In silico molecular docking addition antimicrobial assays used examine efficacy chemical scaffolds...
Medicinal plants have been used from the beginning of human civilization against various health complications. Dengue virus (DENV) has emerged as one most widespread viruses in tropical and subtropical countries. Yet no clinically approved antiviral drug is available to combat DENV infection. Consequently, search for novel antidengue agents medicinal assumed more insistence than previous days. This study focused on 31 potential molecules secondary metabolites examine their inhibitory...
Actinomycetes are natural architects of numerous secondary metabolites including antibiotics. With increased multidrug-resistant (MDR) pathogens, antibiotics that can combat such pathogens urgently required to improve the health care system globally. The characterization actinomycetes available in Nepal is still very much untouched which reason why this paper showcases from based on their morphology, 16S rRNA gene sequencing, and metabolic profiling. Additionally, antimicrobial assays liquid...
Medicinal plants are important reservoirs of bioactive compounds that need to be explored systematically. Because their chemical diversity, natural products provide limitless possibilities for new drug discovery. This study aimed investigate the biochemical properties crude extracts from fifteen Nepalese medicinal plants. The total phenolic contents (TPC), flavonoid (TFC), and antioxidant activity were evaluated through a colorimetric approach while antibacterial activities studied...
Recently, antimicrobial-resistant pathogens and cancers have emerged as serious global health problems, highlighting the immediate need for novel therapeutics. Consequently, we aimed to isolate characterize endophytic
The COVID-19 pandemic has affected higher education institutions (HEIs) worldwide and reshaped the existing educational system. Due to travel constraints physical separation, there been a global shift toward distance learning, Nepal is no exception. This research intends assess practicality of online by evaluating learners' experiences amidst COVID-19. A cross-sectional study was directed among HEIs students in using self-structured questionnaires. Our revealed that 64.6% respondents were...
Cadmium sulfide (CdS) nanoparticles were synthesized by wet chemical coprecipitation method using cadmium chloride and sodium as sulfur sources, respectively. Ascorbic acid was used capping agent. XRD analysis showed that the particles present in hexagonal phase. The average particle size, Debye-Scherer's equation, found to be temperature dependent, 3.1 nm at 20 °C 3.4 45 °C. CdS revealed considerable blue shift absorption edge compare bulk CdS. They exhibited quantum size effect an increase...
The COVID-19 pandemic has affected higher education institutions (HEIs) worldwide and reshaped the existing educational system. Due to travel constraints physical separation, there been a global shift toward distance learning, Nepal is no exception. This research intends assess practicality of online by evaluating learners' experiences amidst COVID-19. A cross-sectional study was directed among HEIs students in using self-structured questionnaires. Our revealed that 64.6% respondents were...
Metabolic profiling of actinomycetes isolated from Nepalese soil has uncovered promising candidates for the development new antimicrobial and anticancer agents. This research examines potential actinobacteria soil, namely strains PY40, PY118, PY122, as sources biological applications. These were identified using 16S rRNA gene sequencing Streptomyces sp. Amycolatopsis PY122. Comprehensive bioassays carried out on ethyl acetate (EA) extract originating fermentation broths these species to...
Nepal is predominately an agrarian country where still the majority of total population rely on agriculture (Adhikari, 2018). The productivity should be augmented to fulfill increasing demand for food. Despite countless efforts, sector could not come across accomplish global market foodstuffs due climate change. By which, plants will attacked by various insects, funguses, and microorganisms. To tackle such problems, pesticides are being widely used defend block products from harmful...
The ZnS semiconductor nanoparticles were synthesized by wet chemical synthesis routes from zinc acetate [Zn(CH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> COO) xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ] as source of and sodium sulfide (Na S) sulfur, where ascorbic acid used capping agents. structural, morphological, optical properties had been characterized X-ray diffraction (XRD), transmission electron microscope (TEM)...
Abstract Hypercholesterolemia has posed a serious threat of heart diseases and stroke worldwide. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid biosynthesis, is regarded as root reactive oxygen species (ROS) that generates atherosclerosis cholesterol crystals. β-Hydroxy β-methylglutaryl-coenzyme A reductase (HMGR) biosynthesis. Although some commercially available inhibiting drugs have effectively reduced level, most them failed to meet requirements being apt drug candidates....