A5058823500- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Curcumin's Biomedical Applications
- Microbial Metabolism and Applications
- Carbohydrate Chemistry and Synthesis
- Ginger and Zingiberaceae research
- Fungal Biology and Applications
- Biochemical and Molecular Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Phytochemistry and Biological Activities
- Ethnobotanical and Medicinal Plants Studies
- Medicinal plant effects and applications
- Biosensors and Analytical Detection
- Medicinal Plants and Neuroprotection
- Advanced biosensing and bioanalysis techniques
- Fermentation and Sensory Analysis
- Metabolomics and Mass Spectrometry Studies
- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Biochemical Analysis and Sensing Techniques
- Essential Oils and Antimicrobial Activity
University of Florida
2023
University of Tübingen
2019-2022
University of Wisconsin–Madison
2022
Kathmandu University
2011
Sun Moon University
2011
Acacia catechu (L.f.) Willd is a profoundly used traditional medicinal plant in Asia. Previous studies conducted this are more confined to extract level. Even though bioassay-based indicated the true therapeutic potential of plant, compound annotation was not performed extensively. This research aimed at assessing bioactivity different solvent extracts followed by its phytoconstituents. Liquid chromatography equipped with high resolution mass spectrometry (LC-HRMS) deployed for...
Antibiotics, nowadays, are not only used for the treatment of human diseases but also in animal and poultry farming to increase production. Overuse antibiotics leads their circulation food chain due unmanaged discharge. These circulating residues a major cause antimicrobial resistance (AMR), so comprehensive multifaceted measures aligning with One Health approach crucial curb emergence dissemination antibiotic through chain. Different chromatographic techniques capillary electrophoresis (CE)...
Natural products have been the center of attraction ever since they were discovered. Among them, plant-based natural popular as analgesics, anti-inflammatory, antidiabetic, and cosmetics possess widespread biotechnological applications. The use plant therapeutics is deep-rooted in Nepalese society. Although there are few ethnobotanical studies conducted, extensive research these valuable medicinal plants has not a priority due to limitation technology infrastructure. Here, we selected 4...
Streptomyces species are prolific sources of bioactive secondary metabolites known especially for their antimicrobial and anticancer activities.This study sought to isolate characterize antioxidant molecules biosynthesized by sp. KTM18. The potential an isolated compound its toxicity were accessed.The was purified using bioassay-guided chromatography techniques. Nuclear magnetic resonance (NMR) experiments carried out structure elucidation. the determined DPPH free radical scavenging assay....
Finding new antibacterial agents from natural products is urgently necessary to address the growing cases of antibiotic-resistant pathogens. Actinomycetes are regarded as an excellent source therapeutically important secondary metabolites including antibiotics. However, they have not yet been characterized and explored in great detail for their utility developing countries such Nepal. In silico molecular docking addition antimicrobial assays used examine efficacy chemical scaffolds...
Actinomycetes are natural architects of numerous secondary metabolites including antibiotics. With increased multidrug-resistant (MDR) pathogens, antibiotics that can combat such pathogens urgently required to improve the health care system globally. The characterization actinomycetes available in Nepal is still very much untouched which reason why this paper showcases from based on their morphology, 16S rRNA gene sequencing, and metabolic profiling. Additionally, antimicrobial assays liquid...
Plants have a pivotal role in ethnopharmacology, and their preparations are use globally. However, getting down to the structure requires an effective workflow mostly time-consuming isolation process. Although bioassay-guided approaches widely popular, they face massive problem of rediscovery recent times, especially plant metabolomics. Mass spectrometry (MS)-based approach incorporated molecular networking via Global Natural Product Social Molecular Networking (GNPS) is considered here for...
A chemical reinvestigation of the Indonesian strain Streptomyces sp. SHP 22-7 led to isolation three new pyrimidine nucleosides, along with six known analogues and zincphyrin. The structures compounds (6, 7, 10) were elucidated by employing spectroscopic techniques (NMR, MS, CD, IR) as well enantioselective analyses methyl branched side chain configurations. Application precursor-directed feeding approach production partial nine further analogues. 6, 11 (2–4) found possess antimycobacterial...
Turmeric, Curcuma longa L., is a type of medicinal plant characterized by its perennial nature and rhizomatous growth. It member the Zingiberaceae family distributed across world’s tropical subtropical climates, especially in South Asia. Its rhizomes have been highly valued for food supplements, spices, flavoring agents, yellow dye Asia since ancient times. exhibits diverse array therapeutic qualities that encompass ability to combat diabetes, reduce inflammation, act as an antioxidant,...
Turmeric, Curcuma longa L., is a type of medicinal plant characterized by its perennial nature and rhizomatous growth. It member the Zingiberaceae family distributed across world’s tropical subtropical climates, especially in South Asia. Its rhizomes are highly valued for food supplements, spices, flavoring agents, yellow dye Asia since ancient times. exhibits diverse array therapeutic qualities that encompass ability to combat diabetes, reduce inflammation, act as an antioxidant, exhibit...
Metabolomics and molecular networking approaches have expanded rapidly in the field of biological sciences involve systematic identification, visualization, high-throughput characterization bioactive metabolites natural products using sophisticated mass spectrometry-based techniques. The popularity pharmaceutical therapies has been influenced by medicinal plants with a long history ethnobotany vast collection compounds. Here, we selected four Cleistocalyx operculatus, Terminalia chebula,...
Nonomuraea sp. strain C10 produces the cytotoxic natural product brartemicin. Here, we report its draft genome sequence to get insight into brartemicin biosynthesis and enable mining for novel secondary metabolites.
Here, we report a 6.2-Mbp draft genome sequence of the bacterium Pseudonocardia sp. strain C8, which gave insight into complete secondary metabolite production capacity and hinted that possibly represents new species.