A5034322918- Spine and Intervertebral Disc Pathology
- Polydiacetylene-based materials and applications
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Advanced biosensing and bioanalysis techniques
- Nanoparticles: synthesis and applications
- Supramolecular Self-Assembly in Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Musculoskeletal pain and rehabilitation
- Antimicrobial Peptides and Activities
- Diverse Scientific Research Studies
- Oral microbiology and periodontitis research
- Pickering emulsions and particle stabilization
- Gas Sensing Nanomaterials and Sensors
- Nanocluster Synthesis and Applications
- Free Radicals and Antioxidants
- Nanoplatforms for cancer theranostics
- Modular Robots and Swarm Intelligence
- Osteoarthritis Treatment and Mechanisms
- Healthcare and Venom Research
- Covalent Organic Framework Applications
- Laser-Ablation Synthesis of Nanoparticles
- Extracellular vesicles in disease
- Metal-Catalyzed Oxygenation Mechanisms
University of Chinese Academy of Sciences
2019-2025
Universidade de Vigo
2023-2025
Wenzhou Medical University
2019-2024
First Affiliated Hospital of Wenzhou Medical University
2022-2024
Wuxi Taihu Hospital
2023
Wenzhou Central Hospital
2023
Chinese Academy of Sciences
2017-2022
Wenzhou University
2019
Affiliated Eye Hospital of Wenzhou Medical College
2019
Southeast University
2017-2018
As intervertebral disc degeneration (IVDD) proceeds, the dysfunctional mitochondria disrupt viability of nucleus pulposus cells, initiating degradation extracellular matrix. To date, there is a lack effective therapies targeting cells. Here, we synthesized polygallic acid-manganese (PGA-Mn) nanoparticles via self-assembly polymerization gallic acid in an aqueous medium and introduced mitochondrial peptide (TP04) onto using Schiff base linkage, resulting PGA-Mn-TP04 nanoparticles. With size...
Osteoarthritis (OA) is a chronic inflammatory joint disease characterized by progressive cartilage degeneration, synovitis, and osteoid formation. In order to effectively treat OA, it important block the harmful feedback caused reactive oxygen species (ROS) produced during wear. To address this challenge, we have developed injectable nanocomposite hydrogels composed of polygallate-Mn (PGA-Mn) nanoparticles, oxidized sodium alginate, gelatin. The inclusion PGA-Mn not only enhances mechanical...
Gold nanobipyramids (Au NBPs) with two sharp tips present an extremely strong electric field enhancement, which endows them more advantages in biomedical photonics than other gold nanostructures. The application of Au NBPs for diagnosis and therapy is now under intensive investigation. Here, we report surface-enhanced Raman scattering (SERS) detection photothermal (PTT) MCF-7 cancer cells both vitro vivo via bioconjugation reporter 2-naphthalenethiol (2-NAP) folic acid (FA). results showed...
Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain, characterized by excessive reactive oxygen species generation and inflammation-induced pyroptosis. Unfortunately, there are currently no specific molecules or materials available effectively delay IVDD. This study develops multifunctional full name of PG@Cu nanoparticle network (PG@Cu). A designed pentapeptide, bonded on nanoparticles via Schiff base bond, imparts multifunctionality the metal polyphenol...
Taking advantage of photothermal conversion, the surface pores water-dispersible single-walled carbon nanotubes assembled on polymer particles were rapidly closed by NIR irradiation to produce macroporous polymeric microspheres with multiple interconnected chambers. These can act as smart containers encapsulate and hold DNA molecules.
Intervertebral disc degeneration (IVDD) is a leading cause of low back pain. The strategy using functional materials to deliver nucleic acids provides powerful tool for ameliorating IVDD. However, the immunogenicity acid vectors and poor mechanical properties greatly limit their effects. Herein, antagomir-204-3p (AM) shows effectively inhibits apoptosis nucleus pulposus cells. Moreover, high-strength biohydrogel based on zinc-oxidized sodium alginate-gelatin (ZOG) designed as multifunctional...
A family of anisotropic particles is synthesized via a facile, scalable, and versatile method based on conventional double emulsion, which very well suited for practical production applications. Partial wetting theory established as powerful instrument to elucidate the controlled phase separation within emulsion. This employed assist manipulation process formation well‐defined nonspherical their triggered release.
Despite the continuous exploration and development of new antibiotics, emergence super-resistant bacteria has led to a gradual loss effectiveness in some antibiotics. Developing methods applying...
Polyphenols exhibit strong antioxidant, and anti-inflammatory but are limited by chemical instability low bioavailability. To address these challenges, we developed polyphenol-amino acid conjugates that self-assemble into stable nanospheres, enhancing their stability These nanoparticles demonstrate significantly improved ROS scavenging efficiency promote cell proliferation in vitro. The incorporation of amino acids enhances biocompatibility facilitates effective elimination. offer a...
Abstract Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron‐dependent form cell death, identified as critical mechanism in IVDD pathogenesis. Herein, the therapeutic potential gallic acid (GA)‐derived PGA‐Cu nanoparticles, enhanced with functional octapeptide (Cys‐Lys‐His‐Gly‐ d ‐Arg‐ ‐Tyr‐Lys‐Phe, SS08) to build mitochondria‐targeted nanoparticles...
Abstract Discogenic pain, caused by intervertebral disc degeneration (IVDD), is a prevalent and challenging condition to treat effectively. Macrophage infiltration with neural ectopic in‐growth resulting from structural disturbances within the (IVD) major cause of discogenic pain. This work systematically reveals how nanoparticles can synergistically regulate immune microenvironment mitochondrial communication attenuate The antioxidant metal‐polyphenol nanoparticle system sequentially...
A straightforward photo-annealing approach was developed for building functional polymer layers on paper. Conducting polyaniline with the ability photothermal conversion can be readily annealed by near-infrared light. The polymers become both insulating and hydrophobic. Selective produces a layer patterned conductive arrays. This material exhibits real-time response to ammonium gas. Complete preserves porous structure but changes wettability of polyaniline-nanofiber film.
We report sequence isomerism-dependent and reversible self-assembly behaviors of glycopeptide mimetics in response to different stimuli. Based on the mimetic assemblies, ON/OFF switching biofilm disruption was achieved.
A hybrid system with a carbon nanotube coating on the shell of polymeric particle is constructed via Pickering emulsion route. Thermal generation from nanotubes under near-infrared illumination actuates phase transition polymer matrix, rapidly triggering shape change. It envisioned that change by near-IR light, combined ease fabrication, opens an avenue to exploit smart drug vehicles.
A versatile and readily scalable approach to fabricate a cheap sensitive paper gas sensor is described. Chemically acidified single-walled carbon nanotubes are assembled in paper, forming continuous sensing arrays with low detection limit high selectivity for ammonia gas.
Enhancing the antibacterial properties by regulating valence configurations of copper: a focus on Cu-carboxyl chelates.