A5089803459- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
- Boron and Carbon Nanomaterials Research
- Pancreatic and Hepatic Oncology Research
- Wound Healing and Treatments
- Bone Tissue Engineering Materials
- Neuroendocrine Tumor Research Advances
- Ocular Infections and Treatments
- Polymer Surface Interaction Studies
- Liver Disease Diagnosis and Treatment
- Fullerene Chemistry and Applications
- Graphene research and applications
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Diabetic Foot Ulcer Assessment and Management
- Cancer-related molecular mechanisms research
- Burn Injury Management and Outcomes
- CO2 Reduction Techniques and Catalysts
- Marine and Coastal Research
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Supramolecular Chemistry and Complexes
- Supramolecular Self-Assembly in Materials
Chinese Academy of Sciences
2018-2025
Suzhou Institute of Nano-tech and Nano-bionics
2024-2025
University of Chinese Academy of Sciences
2017-2024
Northeast Normal University
2023
Wenzhou Medical University
2021-2023
First Affiliated Hospital of Wenzhou Medical University
2023
Affiliated Eye Hospital of Wenzhou Medical College
2021
State Key Laboratory of Polymer Physics and Chemistry
2017-2020
Changchun Institute of Applied Chemistry
2017-2020
University of Science and Technology of China
2018-2020
Abstract Current standard of care dressings are unsatisfactorily inefficacious for the treatment chronic wounds. Chronic inflammation is primary cause long‐term incurable nature Herein, an absorbable nanofibrous hydrogel developed synergistic modulation microenvironment to accelerate diabetic wound healing. The electrospun thioether grafted hyaluronic acid nanofibers (FHHA‐S/Fe) able form a in situ on bed. This degrades and absorbed gradually within 3 days. thioethers HHA can scavenge...
As intervertebral disc degeneration (IVDD) proceeds, the dysfunctional mitochondria disrupt viability of nucleus pulposus cells, initiating degradation extracellular matrix. To date, there is a lack effective therapies targeting cells. Here, we synthesized polygallic acid-manganese (PGA-Mn) nanoparticles via self-assembly polymerization gallic acid in an aqueous medium and introduced mitochondrial peptide (TP04) onto using Schiff base linkage, resulting PGA-Mn-TP04 nanoparticles. With size...
Supramolecular polymeric gels cross-linked by well-defined, discrete metal–organic macrocycles (MOMs) or cages have become a prevailing topic within the field of supramolecular self-assembly. However, realization hydrogels organometallic architectures with good biocompatibility is still great challenge. Herein, we present successful preparation CO2 stimuli-responsive, injectable block copolymer organoplatinum(II) metallacycles. Through combination coordination-driven self-assembly and...
A tetraphenylethylene (TPE)-based supra-amphiphilic organoplatinum(<sc>ii</sc>) metallacycle was successfully prepared, which presented biological application in cell imaging.
In this paper, we demonstrate a strategy of covalently bonding bioactive molecules onto inorganic hydroxyapatite (HAp) to improve the compatibility between organic and components endow bone composites with sustainable bioactivity. Bone morphogenetic protein-2 (BMP-2) peptide immobilized nano-hydroxyapatite (nHAp-BMP-2) is developed preserve bioactivity slow release BMP-2 peptide. Then nHAp-BMP-2 was further incorporated into an ultraviolet-curable mixture gelatin methacrylamide (GelMA)...
Polylactic acid (PLA) is one of the most promising candidates to solve present environmental and energy problems. The programmable three-dimensional (3D) fabrication technique also provides a convenient green platform for PLA applications in bone tissue engineering. An innovative scaffold that combined multiple functions including highly interconnected porosity, sufficient nutrient supply, antibacterial activity was prepared through 3D printing. Porosity 67%, which quite desirable cell...
Abstract Developing functional medical materials is urgent to treat diabetic wounds with a high risk of bacterial infections, glucose levels and oxidative stress. Here, smart copper‐based nanocomposite acidic spray has been specifically designed address this challenge. This pH‐responsive multienzyme‐like properties. It enables the effectively eliminate bacteria alleviate tissue pressure, thereby accelerating healing infected wounds. The works by generating hydroxyl radicals through...
Bacteria have the potential to exhibit divergent stereochemical preferences for different levels of chiral structures, including from molecule, supramolecule, nanomicroscale helical structure. Accordingly, structure-activity relationship between chirality and bactericidal activity remains uncertain. In this study, we seek understand multivalent molecular effect supramolecular polymers on antibacterial activity. Two n-butylazobenzene-modified l- d-tripeptides (abbreviated C4Azo-l-VKK-OH...
Perovskite solar cells (Pero-SCs) are rapidly emerging as a promising photovoltaic technology, yet their performance and stability significantly hampered by defects ion migration. This work introduces ethyl 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylate...
We have performed unconstrained search for low-lying structures of medium-sized silicon clusters Si(31)-Si(40) and Si(45), by means the minimum-hopping global optimization method coupled with a density-functional based tight-binding model silicon. Subsequent geometric using theory PBE, BLYP, B3LYP functionals was carried out to determine relative stability various candidate obtained from search. The characteristics these can be affirmed comparing binding energies per atom previously...
Subunit vaccines are safer but often poorly immunogenic in comparison to traditional vaccines, and thus, adjuvants delivery vehicles needed enhance the immune response. The complement system is a part of innate system, which plays an important role adaptive immunity. Therefore, activation could be utilized as potential strategy for vaccine applications. Herein, cysteamine hydrochloride was grafted onto methoxy poly(ethylene glycol)-block-poly (allyl glycidyl ether)-block-poly(ε-caprolactone)...
Purpose To determine the performance of magnetic resonance (MR) imaging-based tumor metrics for evaluation response to transarterial chemoembolization (TACE) in patients with unresectable intrahepatic cholangiocarcinoma (ICCA). Materials and Methods Ninety-four ICCA underwent baseline follow-up MR imaging after TACE were followed up until death or end study duration. Lesions analyzed anatomic (Response Evaluation Criteria Solid Tumors [RECIST] volume) functional (viable volume, viable...
We performed a constrained search, combined with density-functional theory optimization, of low-energy geometric structures silicon clusters Si(39), Si(40), Si(50), Si(60), Si(70), and Si(80). used fullerene cages as structural motifs to construct initial configurations endohedral structures. For we examined six using all homolog C(34) isomers cage motifs. found that the Si(39) constructed based on C(34)(C(s):2) motif results in new leading candidate for lowest-energy structure whose energy...
Background Differentiating between hepatocellular carcinoma (HCC), focal nodular hyperplasia (FNH), and adenoma (HCA) is usually achievable by MRI. However, in some cases with atypical imaging findings accurate diagnosis may be difficult. Purpose To assess the diagnostic value of volumetric contrast‐enhanced (CE) diffusion‐weighted (DWI) differentiating HCC, FNH, HCA. Study Type Retrospective. Subjects In all, 143 patients (206 lesions): 42 HCA (81 lesions), 51 FNH (65 50 HCC (60 lesions)....
The development of near-infrared (NIR) dyes with desirable photophysical characteristics for tumor therapy is highly expected at present. In this report, IR-780 iodide was loaded by the mercaptopropionic acid grafted poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly(allyl glycidyl ether) [mPEG5K-PCL10K-PAGE6 (MPA)] copolymer to form nanomicelles (IR-780@TBMPA) in aqueous solution. On account hydrophobic and electrostatic interaction between mPEG5K-PCL10K-PAGE6 (MPA) IR-780,...
Data collection is basis and premise for data application, comprehensive analysis, assessment decision-making smart ship. Integrated information platform an advanced solution to application. By using many technologies such as computer technology, communication of all the function-oriented subsystems are aggregated by develop networked, informatized intelligent system integrated monitoring management. The scheme ship 13500TEU container vessel proposed with design architecture, network...