A5019140105- Computational Drug Discovery Methods
- Synthesis and biological activity
- Periodontal Regeneration and Treatments
- Oral and Maxillofacial Pathology
- Enzyme Production and Characterization
- Protein Structure and Dynamics
- Receptor Mechanisms and Signaling
- Heat shock proteins research
- Metabolomics and Mass Spectrometry Studies
- Machine Learning in Bioinformatics
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Effects and Assays
- Machine Learning and ELM
- Tissue Engineering and Regenerative Medicine
- PI3K/AKT/mTOR signaling in cancer
- Body Composition Measurement Techniques
- Biotin and Related Studies
- Frailty in Older Adults
- Head and Neck Surgical Oncology
- Bacteriophages and microbial interactions
- thermodynamics and calorimetric analyses
- Analytical Methods in Pharmaceuticals
- Probiotics and Fermented Foods
- Tuberculosis Research and Epidemiology
- Neonatal and Maternal Infections
Sarojini Naidu Medical College
2018
Institute of Bioinformatics and Applied Biotechnology
2016
Codon Biosciences (India)
2014-2015
Chacha Nehru Bal Chikitsalaya
2013
Maulana Azad Medical College
2013
Soft Imaging LLC (United States)
2013
Sharda University
2011-2013
Alterations in GABAnergic system are implicated the pathophysiology of schizophrenia. Available antipsychotics that target GABA receptor form a desirable therapeutic strategy treatment regimen schizophrenia, unfortunately, suffer serious setback due to their prolonged side effects. The present investigation focuses on developing QSAR models from biological activity herbal compounds and derivatives promise be alternative candidates uptake inhibitors.Three sets were undertaken study develop...
Since the discovery of Hsp90, a decade ago, it has surfaced as potential target in breast cancer therapy along with other cancers. In present study, we have selected seven established Hsp inhibitors viz., PU3, CCT-018159, CNF-2024, SNX-5422, NVP (AUY-922), EGCG and IPI-504 used treatment cancer. Considering these parent compound, ligand based search was carried out 90% similarity Pubchem database (31 million compounds). All similar molecules belonging to respective compound were subjected...
DNA-synthesis, DNA-repair, and DNA imprinting processes require efficient conversion of homocysteine to methionine. This methylation is catalyzed by methylentetrahydrofolate reductase through reduction 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate. Normal synthesis considered critical for physiological functions body. The enzyme coded the gene with symbol MTHFR on chromosome 1 location p36.3 in humans. At least 24 mutations have been identified people homocystinuria. There...
β2 agonists and anticholinergics are two major classes of bronchodilators which form first line drugs recommended in symptomatic treatment asthma COPD. Combinational therapy involving β prove more effective treating airway disease than use either agent alone. In present investigation, binding modes Muscarinic Antagonism 2 Agonism (MABA) conjugates designed by Lyn et al. were revealed on structural grounds adopting molecular docking techniques. The tether motif onto M3 makes it a single...
Deficits in cholinergic neurotransmission due to the degeneration of neurons brain are believed be one major causes memory impairments associated with AD. Targeting acetyl cholinesterase (AChE) surfaced as a potential therapeutic target treatment Alzheimer's disease. The present study is pursued develop quantitative structure activity relationship (QSAR) models determine chemical descriptors responsible for AChE activity.Two different sets inhibitors, dataset-I (30 compounds) and dataset-II...
Development of natural antimicrobial strategies has always attracted researchers, as disease outbreaks are recognized im- portant constraints to living organisms because the development antibiotic resistance in microorganisms. Use probiotic bacteria been practice alternatives antimicrobials control microbial agents. Probiotics, and beneficial micro flora widely accepted used farming aquaculture its diversified applications. It improves water pond sedi- ment quality which inturn aquatic life....
Linear and non-linear QSAR studies have been performed in present investigation with multiple linear regressions (MLR) analysis Support vector machine (SVM) using different kernels. Three relevant descriptors out of fifteen calculated are identified as LOGP values, G3e Rte+. Their relationship biological activity IC50 provided structural insights interpretation serializing the results into a pragmatic approachable technique. models obtained show statistical fitness good predictability. SVM...
The term ‘accident’ is often used to describe a multitude of disparate events from falls and road accidents suicides violence. A ‘fatal accident’ for this purpose defined as one in which death occurs within 30 days. Falls, burns are major categories lead the highest rates mortality among Geriatric Population. In most studies cited ‘elderly people’ those aged 60 or over with rates, particularly age group 85 over. 2006, approximately 76.6 million (above 7.7% total population) India alone...
Introduction: Falls from height are the one of major trauma cases presenting to emergency departments and often cause mortality morbidity.
Severe atrophy of the residual alveolar ridges poses a clinical challenge for successful prosthodontic rehabilitation.Extreme resorption ridge whether maxilla or mandible will lead to reduced denture bearing area which in turn affect retention, stability and support complete denture.The severely atrophied jaw can have various treatment options.For more than 150 years, it was believed that weight lower contributes both retention stability.This concept internally weighted suggested gravity...