A5019885656- Liver Disease Diagnosis and Treatment
- Ovarian function and disorders
- Diet, Metabolism, and Disease
- Sleep and related disorders
- Resilience and Mental Health
- School Health and Nursing Education
- Sleep and Wakefulness Research
- Hormonal Regulation and Hypertension
- Child Nutrition and Water Access
- Vascular Malformations and Hemangiomas
- Reproductive Biology and Fertility
- Early Childhood Education and Development
- Hormonal and reproductive studies
- Genetic and Kidney Cyst Diseases
- Pancreatitis Pathology and Treatment
- Lipid metabolism and disorders
- Obesity, Physical Activity, Diet
- Sexual Differentiation and Disorders
- Renal and related cancers
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Disease and Adiposity
University of Colorado Anschutz Medical Campus
2019-2024
University of Colorado Denver
2019-2022
Children's Hospital Colorado
2019-2021
Rocky Vista University
2021
Abstract Objective Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, insulin resistance, and hepatic steatosis (HS). Because dietary essential amino acid (EAA) supplementation has been shown to decrease HS in various populations, this study's objective was determine whether would PCOS. Methods A randomized, double‐blind, crossover, placebo‐controlled trial conducted 21 adolescents with PCOS (BMI 37.3 ± 6.5 kg/m 2 , age 15.6 1.3 years). Liver fat, very low‐density...
Polycystic ovary syndrome (PCOS) is common and diagnosis requires an elevated testosterone. The clinical importance of adrenal 11-oxyandrogens in PCOS unclear.We sought to determine if 1) better identify compared testosterone, 2) predict comorbidities PCOS, 3) are altered with combined oral contraceptive pill (COCP) or metformin therapy.Data from 200 adolescent female participants aged 12 21 years, most obesity, enrolled across 6 studies pediatric endocrinology were included: 70 non-PCOS...
Abstract Megalencephaly‐capillary malformation syndrome (MCAP) is a brain overgrowth disorder characterized by cortical malformations (specifically polymicrogyria), vascular anomalies, and segmental secondary to somatic activating mutations in the PI3K‐AKT–MTOR pathway ( PIK3CA ). Cases of growth failure hypoglycemia have been reported patients with MCAP, raising suspicion for unappreciated hormone (GH) deficiency. Here we report an observational multicenter study children MCAP GH Eleven...
Abstract Context Steatotic liver disease is common but overlooked in childhood obesity; diagnostic methods are invasive or expensive. Objective We sought to determine the accuracy of vibration-controlled transient elastography (VCTE) compared with magnetic resonance imaging (MRI) adolescents obesity and high risk for hepatosteatosis. Methods Baseline data 3 clinical trials enrolling were included (NCT03919929, NCT03717935, NCT04342390). Liver fat was assessed using MRI fraction VCTE-based...
Abstract Objective Adolescents with polycystic ovary syndrome (PCOS) and obesity can have insulin resistance, dysglycemia, hepatic steatosis. Excess pancreatic fat may disturb secretion relate to fat. Associations between fraction (PFF) metabolic measures in PCOS were unknown. Methods This secondary analysis included 113 sedentary, nondiabetic adolescent girls (age = 15.4 [1.9] years), or without BMI ≥ 90th percentile. Participants underwent fasting labs, oral glucose tolerance tests,...
Purpose To examine the role of sleep in a school-based resiliency intervention. Design Single group feasibility study. Setting Urban middle school Subjects Sixth grade students. Intervention A total 285, 11–12-year-old students (70% White, 18% Hispanic, 55% female) participated six-week 1:1 Healthy Kids Youth (n = 248) completed electronic surveys at pre–post 6-week study assessing mental health parameters and self-reported bed wake time. Measures Students were categorized as having...
Abstract Disclosure: D. Sundararajan: None. J.S. Lo: N. Morelli: Y. Garcia-Reyes: M.A. Ware: H. Rahat: S. Sundaram: C. Severn: L.L. Pyle: E. Tas: M.G. Cree: Consulting Fee; Self; Pollie, Inc. Research Investigator; Amino Corp. Obesity affects nearly 20% of adolescents in the United States. Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity, affecting between 40-70% youth with obesity, thus approximately 10% States youth. Traditional diagnostic methods for NAFLD are expensive or...
Abstract Disclosure: J.S. Lo: None. F. Bril: A. Taylor: N. Morelli: M.A. Ware: Y. Garcia-Reyes: M.J. McPhaul: Employee; Self; Quest Diagnostics. M.G. Cree: Consulting Fee; Pollie, Inc. Research Investigator; Amino Corp. Adolescents with obesity and polycystic ovary syndrome (PCOS) have significant insulin resistance are at high risk of nonalcoholic fatty liver disease (NAFLD). This may be related to increased growth hormone associated puberty, in addition excess testosterone. NAFLD is...
Abstract Background Polycystic ovary syndrome (PCOS) is common and associated with metabolic disease, in particular glucose abnormalities insulin resistance (IR). Fat metabolism linked IR, manifesting as decreased suppression of lipolysis following meals, inflammation, ectopic fat accumulation. Our previous work demonstrated adipose IR during a hyperinsulinemic-euglycemic clamp increased hepatic adolescents PCOS. We hypothesized that postprandial would be altered compared to controls...
Abstract PCOS is common in adolescents and includes excess testosterone concentrations. The clinical importance of 11-oxyandrogens unclear. We sought to determine if fasted morning 11-oxyandrogens: 1) better identify diagnosis compared testosterone, 2) relate comorbidities PCOS, 3) are altered with combined oral contraceptive pill (COCP) or metformin therapy. Data from 186 adolescent females aged 12-21 years, mostly obese, enrolled one 6 studies our division were included: 115 untreated (13...
Abstract Introduction To examine the role of sleep health in a school-based coaching resiliency intervention for 6th grade students. We hypothesized that participants with insufficient would have poorer mental outcomes and be less successful youth poor health. Methods A total 285, 11-12-year-old students (72% white, 18% Hispanic, 55% female) participated six-week 1:1 Healthy Kids intervention. Youth completed electronic surveys at baseline 6-week follow-up assessing parameters self-reported...