A5090609332- Cystic Fibrosis Research Advances
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Immunodeficiency and Autoimmune Disorders
- Esophageal and GI Pathology
- Child Nutrition and Feeding Issues
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neonatal Respiratory Health Research
- Metabolism, Diabetes, and Cancer
- Dysphagia Assessment and Management
- Antifungal resistance and susceptibility
- Tracheal and airway disorders
- Botulinum Toxin and Related Neurological Disorders
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Pain Mechanisms and Treatments
- Fungal and yeast genetics research
- Congenital Ear and Nasal Anomalies
- Metabolomics and Mass Spectrometry Studies
- DNA Repair Mechanisms
- Pharmaceutical studies and practices
- Adipose Tissue and Metabolism
- Fungal Infections and Studies
University of Colorado Denver
2016-2025
University of Colorado Anschutz Medical Campus
2013-2024
Children's Hospital Colorado
2015-2024
Manila Observatory
2022
New England College of Optometry
2019
Optum (United States)
2019
The Medical Center of Aurora
2018-2019
University of Colorado Health
2018
Temasek Polytechnic
2017
Sinai Hospital
2016
Haplotype maps (HapMaps) reveal underlying sequence variation and facilitate the study of recombination genetic diversity. In general, HapMaps are produced by analysis Single-Nucleotide Polymorphism (SNP) segregation in large numbers meiotic progeny. Candida albicans, most common human fungal pathogen, is an obligate diploid that does not appear to undergo meiosis. Thus, standard methods for haplotype mapping cannot be used. We exploited naturally occurring aneuploid strains determine...
There are no treatments for the extreme hyperphagia and obesity in Prader-Willi syndrome (PWS). The bestPWS clinical trial assessed efficacy, safety tolerability of methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib. Participants with PWS (12-65 years old) were randomly assigned (1:1:1) to biweekly placebo, 1.8 mg beloranib or 2.4 injection 26 weeks at 15 US sites. Co-primary endpoints changes [measured by Hyperphagia Questionnaire Clinical Trials (HQ-CT); possible score 0-36] weight...
Continuous glucose monitoring (CGM) is an essential part of diabetes care. Real-time CGM data are beneficial to patients for daily management, and aggregate summary statistics measures valuable direct insulin dosing as a tool researchers in clinical trials. Yet, the various commercial systems still report disparate, non-standard ways. Accordingly, there need standardized, free, open-source approach management analysis. A package titled cgmanalysis was developed free programming language R...
ABSTRACT Drug resistance has become a major problem in the treatment of Candida albicans infections. Genome changes, such as aneuploidy, translocations, loss heterozygosity, or point mutations, are often observed clinical isolates that have resistant to antifungal drugs. To determine whether these types alterations result when DNA repair pathways eliminated, we constructed yeast strains bearing deletions six genes involved mismatch ( MSH2 and PMS1 ) double-strand break MRE11, RAD50, RAD52 ,...
The optimal screening test for diabetes and prediabetes in obese youth is controversial. We examined whether glycosylated hemoglobin (HbA1c) or the oral glucose tolerance (OGTT) a better predictor of free-living glycemia as measured by continuous monitoring (CGM). This was cross-sectional study 10–18 years old, body mass index (BMI) 85th percentile greater, with risk factors. Participants (n = 118) BMI not on medications management, were recruited from primary care pediatric endocrinology...
In cystic fibrosis (CF), hemoglobin A1c (HbA1c) is thought to underestimate glycemia. However, few studies have directly assessed the relationship between HbA1c and average glucose in CF. We determined relationships among glycemic markers-HbA1c, fructosamine (FA), glycated albumin (%GA), 1,5-anhydroglucitol (1,5-AG)-and continuous monitoring (CGM) CF, hypothesizing that alternate markers would better predict sensor (ASG) than HbA1c.CF participants a group of healthy control subjects (HCs),...
Hemoglobin A1c (HbA1c) is increasingly performed over the oral glucose tolerance test (OGTT) as initial screening for type 2 diabetes in youth. However, optimal strategy identifying youth remains controversial. Alternate glycemic markers have been proposed potentially useful tools screening. We examined relationships among fructosamine (FA), glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG) with traditional tests, HbA1c OGTT. Youth 10–18 yrs, BMI ≥85th‰, <7.5% had a single visit...
OBJECTIVE Obese youth without diabetes with monophasic oral glucose tolerance test (OGTT) response curves have lower insulin sensitivity and impaired β-cell function compared those biphasic curves. The OGTT curve has not been studied in youth-onset type 2 diabetes. Here we the hypothesis that at randomization TODAY (Treatment Options for Type Diabetes Adolescents Youth) study forecasts heightened glycemic failure rates accelerated decline function. RESEARCH DESIGN AND METHODS OGTTs (n = 662)...
Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity in patients with cystic fibrosis (CF). Prevalence of CFRD increases age and greater severe mutations. Other risk factors associated are female sex, pancreatic insufficiency, liver disease, need for gastrostomy tube feedings, history bronchopulmonary aspergillosis, poor pulmonary function. related to worse clinical outcomes increased mortality. Early diagnosis treatment have been shown improve outcomes. Screening...
Objective To determine whether the alternate glycemic markers, fructosamine (FA), glycated albumin (GA), and 1,5-anhydroglucitol (1,5AG), predict variability captured by continuous glucose monitoring (CGM) in obese youth with prediabetes type 2 diabetes (T2D). Study Design Youth BMI ≥85th%ile, 10-18 years, had collection of fasting plasma (FPG), hemoglobin A1c (HbA1c), FA, GA, 1,5AG 72 hours CGM. Participants HbA1c ≥5.7% were included. Relationships between markers CGM variables determined...
OBJECTIVE Data related to diabetic neuropathy in youth with type 2 diabetes are limited. We examined the relationship of glycemic control, sex, race/ethnicity, BMI, and other diabetes-associated factors development peripheral (DPN) enrolled Treatment Options for Type Diabetes Adolescents Youth (TODAY) study. RESEARCH DESIGN AND METHODS The Michigan Neuropathy Screening Instrument (MNSI) a 10-g monofilament exam were performed annually. DPN was defined as score (&gt;2) on MNSI-exam or...
Polycystic ovary syndrome (PCOS) is common and diagnosis requires an elevated testosterone. The clinical importance of adrenal 11-oxyandrogens in PCOS unclear.We sought to determine if 1) better identify compared testosterone, 2) predict comorbidities PCOS, 3) are altered with combined oral contraceptive pill (COCP) or metformin therapy.Data from 200 adolescent female participants aged 12 21 years, most obesity, enrolled across 6 studies pediatric endocrinology were included: 70 non-PCOS...
Candida albicans, clinically the most important human fungal pathogen, rapidly develops resistance to antifungal drugs. The acquisition of has been linked various types genome changes. As part an ongoing study this problem, we investigated mutation, stability and drug in C. albicans strains with deletions base excision repair (BER) genes NTG1, APN1 OGG1, nucleotide (NER) RAD2 RAD10. BER mutants did not exhibit any change their susceptibility DNA-damaging agents, but NER were extremely...