A5010941560- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- Menopause: Health Impacts and Treatments
- Testicular diseases and treatments
- Estrogen and related hormone effects
- Gestational Trophoblastic Disease Studies
- Gynecological conditions and treatments
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Multiple and Secondary Primary Cancers
- Ectopic Pregnancy Diagnosis and Management
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Growth Hormone and Insulin-like Growth Factors
- Pregnancy-related medical research
- Hypothalamic control of reproductive hormones
- Birth, Development, and Health
Fudan University
2024
National Taiwan University
2004-2023
Second Affiliated Hospital of Nanjing Medical University
2017
Taipei Veterans General Hospital
2016
National Yang Ming Chiao Tung University
2016
National Taiwan University Hospital
2003-2015
In-Q-Tel
2011
Penn Presbyterian Medical Center
2002
Eunice Kennedy Shriver National Institute of Child Health and Human Development
1984
National Institutes of Health
1984
Abstract Reports of the bone-protective effects resveratrol, a naturally occurring phytoestrogen and agonist for longevity gene SIRT1, have highlighted this compound as candidate therapy osteoporosis. Moreover, SIRT1 antagonism enhances adipogenesis. There has been speculation that resveratrol can promote osteogenesis through but mechanism remains unclear. In study we investigated molecular how modulate lineage commitment human mesenchymal stem cells to other than We found promoted...
Abstract Objective To compare tumor characteristics and clinical outcome of patients with cervical locally advanced adenocarcinoma ( AC )/adenosquamous carcinoma ASC ) squamous cell SCC ). Design Retrospective study. Setting National Taiwan University Hospital, Taipei, Taiwan. Population All n = 35), or 194) FIGO stage ≥IIB who received definitive radiotherapy concurrent chemoradiotherapy CCRT from January 1995 to December 2009. Method Medical histopathological record review. Main measures...
To investigate the clinical significance of tumor-infiltrating lymphocytes (TILs) within tumor milieu, we quantitatively measured and compared subpopulations TILs in 24 patients with stage I–III breast carcinoma. Peripheral blood mononuclear cells (PBMCs), normal parenchyma-infiltrating (NILs), were isolated from tissue specimens quantified by flow cytometry. The results showed that increased proportion CD8+ T cells, decreased CD4+ was significant gated CD3+ as to autologous NILs or PBMCs (P...
// Ruey-Jien Chen 1 , Chia-Tung Shun 2 Men-Luh Yen Chia-Hung Chou and Ming-Chieh Lin Department of Obstetrics Gynecology, National Taiwan University, Taipei 100, Pathology, Correspondence to: Chen, email: rjchen@ntuh.gov.tw Keywords: G9a, angiogenesis, cancer cell proliferation, xenograft, patient survival Received: April 09, 2016 Accepted: May 12, 2017 Published: July 07, ABSTRACT Research suggests that the epigenetic regulator a H3K9 histone methyltransferase, is involved in invasion...
BACKGROUND: The aim of this study was to evaluate telomerase activity in tissue from cases gestational trophoblastic disease (GTD) and placental early late human pregnancies. METHODS: We used a telomeric repeat amplification protocol assay measure 132 samples normal pregnancies, spontaneous abortions, late-pregnancy intrauterine fetal death, GTD. RESULTS: Telomerase detected more often pregnancies GTD than abortions (P < 0.001). During gestation, no significant difference detection rates...
The expression of lysophosphatidic acid (LPA)-specific receptors in cervical cancer has not been clearly defined. In this study, we identified LPA1, LPA2 and LPA3 receptors' mRNA SiHa, HeLa CaSki cell lines by RT-PCR. These were associated with tumor proliferation vitro. We then used a xenograph animal model to evaluate the effects these on vivo tumorigenicity. When SiHa cells different receptor patterns seeded backs SCID mice, resulting knockout both significantly attenuated growth;...
Context: The corpus luteum is a dynamic endocrine structure with periodic development and regression during menstrual cycles. Its lifespan can be prolonged by human chorionic gonadotropin (hCG). However, the signal mechanisms of this phenomenon remain unclear.