A5100702423- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Bone and Joint Diseases
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Parkinson's Disease Mechanisms and Treatments
- Bone health and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 and Mental Health
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Vitamin D Research Studies
- Mesenchymal stem cell research
- Inflammatory mediators and NSAID effects
- Bone health and osteoporosis research
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Natural product bioactivities and synthesis
- Autoimmune and Inflammatory Disorders Research
- Genetic Associations and Epidemiology
Northeast Agricultural University
2025
Henan University
2025
Henan University Huaihe Hospital and Huaihe Clinical Institute
2014-2024
Zhongshan Hospital of Xiamen University
2023
Jiangsu University
2018-2021
Fujian Medical University
2018-2021
Fujian Provincial Hospital
2020
The coronavirus disease 2019 (COVID-19) can lead to neurological symptoms such as headaches, confusion, seizures, hearing loss, and loss of smell. link between COVID-19 Parkinson's (PD) is being investigated, but more research needed for a definitive connection.
Abstract The majority of human infectious diseases originate from mammals and are inherently zoonotic. Non-human primates (NHPs) not only carriers many zoonotic pathogens, but also the best intermediary for virus shift harmless to harmful due their similar phylogenetic relationship with humans. Knowledge NHP viral composition its underlying information can therefore provide an assessment risk cross-species transmission spillover diseases. However, studies that have successfully eliminated...
The emergence and rapid development of antibiotic resistance poses a serious threat to global public health. Streptococcus suis (S. suis) is an important zoonotic pathogen, the its has made infections difficult treat. combination non-antibiotic compounds with antibiotics considered promising strategy against multidrug-resistant bacteria. However, mechanism by which metabolites act as adjuvant remains unclear. Here, we found that guanosine metabolism was repressed in S. suis. Exogenous...
Abstract Background Parkinson’s disease (PD), a globally prevalent neurodegenerative disorder, has been implicated with oxidative stress (OS) as central pathomechanism. Excessive reactive oxygen species (ROS) trigger neuronal damage and may induce disulfidptosis—a novel cell death modality not yet characterized in PD pathogenesis. Method Integrated bioinformatics analyses were conducted using GEO datasets to identify PD-associated differentially expressed genes (DEGs). These subjected to:...
Osteomyelitis, an infection of the bone and marrow, imposes a heavy burden on public health care systems owing to its progressive destruction sequestration. Human mesenchymal stem cells (hBMSCs) play key role in process formation, mounting evidence has confirmed that long noncoding RNAs (lncRNAs) are involved hBMSC osteogenic differentiation. Nevertheless, exact function molecular mechanism lncRNAs differentiation during osteomyelitis development remain be explored. In this study, hBMSCs...
Objectives: Osteosarcoma (OsC) is the most common primary bone malignant tumor with lower incidence and high degree of malignancy, but exact mechanism remains unknown. More evidence demonstrated microRNAs (miRNAs) could contribute to progression. In this study, we investigated expression functions miR-320 in OsC cells. Materials Methods: levels several human cell lines normal osteoblastic line were tested by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR)....
Osteosarcoma (OS) is a common malignant bone cancer and still growing threat to young people. Circular RNAs (CircRNAs) are reported be involved in the development of diverse human cancers. However, role circUBAP2 OS progression rarely reported.Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted detect expression levels miR-641 tissues cells. Cell Counting Kit-8 (CCK-8) assay employed check cell proliferation. The ability invasion evaluated by transwell assay. protein...
ABSTRACT The molecular mechanism of autophagy in Lactoferrin (LF) induced osteoblast differentiation is not fully demonstrated. In this study, alkaline phosphatase (ALP) activity, alizarin red S staining and ELISA were used to study N-terminal propeptide type I procollagen (PINP) expression. mRFP-GFP-LC3 adenoviruses, mono-dansylcadaverine (MDC) staining, scanning electron microscopy, western blot analysis was employed probe the LF autophagy. interaction between receptor Neighbor Brca1 gene...
Abstract Multiple proinflammatory conditions, including chemotherapy, radiotherapy, transplant rejection, and microbial infections, have been identified to induce involution of the thymus. However, underlying cellular molecular mechanisms these inflammatory conditions inducing apoptosis thymic epithelial cells (TECs), main components thymus, remain largely unknown. In circulation, mature dendritic (mDCs), predominant initiator innate adaptive immune response, can migrate into Herein, we...
Objective To evaluate the protective effects of hydrogen sulfide supplementation against osteoporosis in diabetic rats.Methods The rat model was established 90 two-month-old SD rats,and injected with sodium sulfide.The rats were randomly divided into three groups:group A,sham control (SHAM) ; group B,diabetic rats; and C,rats supplemented sulfide.At 2nd,4th 6th week after establishment blood glucose,sugar tolerance bone density measured rats.Results showed a significant decrease glucose...
Objective To evaluate the effects of hydrogen sulfide on interleukin(IL)-1, tumor necrosis factor(TNF)-α levels in type Ⅱ diabetic rats with osteoporosis. Methods We studied 90 adult male Wistar aged 2 months, and divided into three groups: A group:25 as control group (A group), 29 osteoporosis B group, 30 dealt sulfide(C group); after ovariectomy 2, 4 6 weeks, blood samples were collected to detect IL- 1, TNF-α levels. Results After IL-1, electrophoresis result image analyze...