A5048439092- RNA Research and Splicing
- RNA regulation and disease
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Receptor Mechanisms and Signaling
- High Altitude and Hypoxia
- Mitochondrial Function and Pathology
- Climate Change and Health Impacts
- Health and Lifestyle Studies
- Ion channel regulation and function
- Chronic Kidney Disease and Diabetes
- Neuroscience of respiration and sleep
- Erythropoietin and Anemia Treatment
- Biomarkers in Disease Mechanisms
- Muscle metabolism and nutrition
- Neuroscience and Neuropharmacology Research
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Sirtuins and Resveratrol in Medicine
- RNA and protein synthesis mechanisms
- Systemic Sclerosis and Related Diseases
Radboud University Nijmegen
2025
Universidad Nacional de Colombia
2015-2022
Life Science Zurich
2021
University of Zurich
2021
ETH Zurich
2021
Universidad de Guanajuato
2014
Suicide is a major public health concern, and the number of deaths by suicide has been increasing in recent years US. There are various biological risk factors for suicide, but causal molecular mechanisms remain unknown, suggesting that investigation novel integrative approaches necessary. Transfer (t)RNAs their modifications, including cytosine methylation (m5C), have received little attention regarding role normal or diseased brain function, though they dynamic mediators protein synthesis....
Synaptic targeting with subcellular specificity is essential for neural circuit assembly. Developing neurons use mechanisms to curb promiscuous synaptic connections and direct synapse formation defined compartments. How this selectivity achieved molecularly remains enigmatic. Here, we discover a link between mRNA poly(A)-tailing axon collateral branch-specific connectivity within the CNS. We reveal that RNA-binding protein Musashi binds encoding receptor tyrosine phosphatase Ptp69D, thereby...
the development of this research is base on growing interest in understanding adaptations to chronic hipoxia mainly range intermediate altitudes (1 500-3 000 m.s.n.m) and need establish parameters normality variables [Hb], Hct SO2 for diagnostic characterization population purposes.to analyze behavior SaO2 at different (970 m.s.n.m, 1 520 728 923 2 180 m.s.n.m 600 order contribute knowledge high altitude physiology clinical field support diagnosis anemia.clinically healthy subjects with low...
<h3>Background</h3> Obesity and sedentary lifestyle has increased in the last years. In Mexico, The Ministry of Education included information for children about physical activity nutrition elementary schools, another hand, Health suggest program ‘5 steps health’ (5SH), which is based theory to change habits. <h3>Aim</h3> Investigate healthy habits 10 12 years old comparing traditional education Vs ‘5SH’ <h3>Methods</h3> Children were randomly assigned group (n = 101, 1 session/week) or 5SH...
Although lithium has long been one of the most widely used pharmacological agents in psychiatry, its mechanisms action at cellular and molecular levels remain poorly understood. One targets Li+ is phosphoinositide pathway, but whereas impact on inositol lipid metabolism well documented, information physiological effects level lacking. We examined two mammalian cell lines effect acute exposure mobilization internal Ca2+ phospholipase C (PLC)-dependent membrane conductances. first corroborated...
<h3>Introduction</h3> Obesity is a risk factor for mitochondrial dysfunction and cardiovascular metabolic diseases. In previous research, we demonstrated that 12 weeks of aerobic training (AT) increased the content SIRT3 protein in skeletal muscle sedentary obese adolescents. improves function. There are not studies have compared effect AT resistance (RT) on content. <h3>Object</h3> To compare versus RT <h3>Methods</h3> Twenty-seven male adolescents (age: 16.7 ± 0.9 years; BMI: 33.7 4.3...