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Huiping Chen

ORCID: 0000-0003-0308-7415
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About
Contact & Profiles
A5047141334
Research Areas
  • Cancer Immunotherapy and Biomarkers
  • CAR-T cell therapy research
  • Immune cells in cancer
  • Nanoplatforms for cancer theranostics
  • Phagocytosis and Immune Regulation
  • Epigenetics and DNA Methylation
  • Ferroptosis and cancer prognosis
  • Cancer, Lipids, and Metabolism
  • Immune Cell Function and Interaction

Sun Yat-sen Memorial Hospital
 2023-2024

Sun Yat-sen University
 2023-2024

Guangzhou Regenerative Medicine and Health Guangdong Laboratory
 2023

 CD8+ T cell–Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance
OPENALEX - Publications 
Liyan Lao Wenfeng Zeng Penghan Huang Huiping Chen Zishuo Jia and 7 more Pei Wang Di Huang Jia-Ning Chen Yan Nie Linbin Yang Wei Wu Jiang Liu

Abstract The therapeutic efficacy of chemotherapy is in part a result its ability to enhance adaptive antitumor immune responses. However, tumor cells exploit various evasion mechanisms escape the attack and blunt chemosensitivity. Herein, we report that through single-cell profiling microenvironment, identified subset CD161-overexpressing CD8+ T enriched chemoresistant tumors. CD161 engagement repressed calcium influx cytolytic capacity acid sphingomyelinase activation ceramide generation....

10.1158/2326-6066.cir-22-0356 article EN cc-by-nc-nd Cancer Immunology Research 2023-01-05
 Simeprevir induces ferroptosis through β-TrCP/Nrf2/GPX4 axis in triple-negative breast cancer cells
OPENALEX - Publications 
Zhirong Lin Z. George Liu Xinyu Yang Zhilong Pan Yaxin Feng and 7 more Yunyi Zhang Huiping Chen Liyan Lao Jianing Chen Fujun Shi Chang Gong Wenfeng Zeng

10.1016/j.biopha.2024.117558 article EN Biomedicine & Pharmacotherapy 2024-10-14
 Data from CD8<sup>+</sup> T cell–Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance
OPENALEX - Publications 
Liyan Lao Wenfeng Zeng Penghan Huang Huiping Chen Zishuo Jia and 7 more Pei Wang Di Huang Jia-Ning Chen Yan Nie Linbin Yang Wei Wu Jiang Liu

&lt;div&gt;Abstract&lt;p&gt;The therapeutic efficacy of chemotherapy is in part a result its ability to enhance adaptive antitumor immune responses. However, tumor cells exploit various evasion mechanisms escape the attack and blunt chemosensitivity. Herein, we report that through single-cell profiling microenvironment, identified subset CD161-overexpressing CD8&lt;sup&gt;+&lt;/sup&gt; T enriched chemoresistant tumors. CD161 engagement repressed calcium influx cytolytic capacity acid...

10.1158/2326-6066.c.6551199 preprint EN 2023-04-04
 Supplementary Figures and Tables from CD8<sup>+</sup> T cell–Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance
OPENALEX - Publications 
Liyan Lao Wenfeng Zeng Penghan Huang Huiping Chen Zishuo Jia and 7 more Pei Wang Di Huang Jia-Ning Chen Yan Nie Linbin Yang Wei Wu Jiang Liu

&lt;p&gt;Supplementary figures S1-S8 and tables S1-S6&lt;/p&gt;

10.1158/2326-6066.22546539 preprint EN cc-by 2023-04-04
 Data from CD8<sup>+</sup> T cell–Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance
OPENALEX - Publications 
Liyan Lao Wenfeng Zeng Penghan Huang Huiping Chen Zishuo Jia and 7 more Pei Wang Di Huang Jia-Ning Chen Yan Nie Linbin Yang Wei Wu Jiang Liu

&lt;div&gt;Abstract&lt;p&gt;The therapeutic efficacy of chemotherapy is in part a result its ability to enhance adaptive antitumor immune responses. However, tumor cells exploit various evasion mechanisms escape the attack and blunt chemosensitivity. Herein, we report that through single-cell profiling microenvironment, identified subset CD161-overexpressing CD8&lt;sup&gt;+&lt;/sup&gt; T enriched chemoresistant tumors. CD161 engagement repressed calcium influx cytolytic capacity acid...

10.1158/2326-6066.c.6551199.v1 preprint EN 2023-04-04
 Supplementary Figures and Tables from CD8<sup>+</sup> T cell–Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance
OPENALEX - Publications 
Liyan Lao Wenfeng Zeng Penghan Huang Huiping Chen Zishuo Jia and 7 more Pei Wang Di Huang Jia-Ning Chen Yan Nie Linbin Yang Wei Wu Jiang Liu

&lt;p&gt;Supplementary figures S1-S8 and tables S1-S6&lt;/p&gt;

10.1158/2326-6066.22546539.v1 preprint EN 2023-04-04
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