A5085593319- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Advanced Fluorescence Microscopy Techniques
- Cancer-related gene regulation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Retinal and Macular Surgery
- Genetic Syndromes and Imprinting
- Cancer Cells and Metastasis
- Chemical Reactions and Isotopes
- Estrogen and related hormone effects
- Chemokine receptors and signaling
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Breast Cancer Treatment Studies
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Immune cells in cancer
Duke Kunshan University
2024
Sun Yat-sen Memorial Hospital
2022-2024
Sun Yat-sen University
2022-2024
Carle Foundation Hospital
2014-2023
Abstract Wide local excision (WLE) is a common surgical intervention for solid tumors such as those in melanoma, breast, pancreatic, and gastrointestinal cancer. However, adequate margin assessment during WLE remains significant challenge, resulting reinterventions to achieve control. Currently, no label-free imaging method available surgeons examine the resection bed vivo microscopic residual Optical coherence tomography (OCT) enables real-time high-resolution of tissue microstructure....
Intraoperative imaging of tumor microenvironment reveals correlations between extracellular vesicle density and breast pathology.
Abstract The heterogeneity of cancer-associated fibroblasts (CAFs) might be ascribed to differences in origin. CD10 and GPR77 have been reported identify a chemoresistance-inducing CAF subset breast cancer. However, the precise mechanism for formation + CAFs remains unknown. In this study, we found that CCL18 expression was positively correlated with density cancer associated poor response chemotherapy. Moreover, secreted by tumor-associated macrophages (TAMs) activated phenotype normal...
Evaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption resection lymphatic structure, whether nodes or axillary contents, histological examination. While reasonably effective at detection macrometastasis, majority resected are histologically negative. Improvements need to be made better detect micrometastasis, minimize eliminate complications, provide...
We report the development and implementation of an intraoperative polarization-sensitive optical coherence tomography (PS-OCT) system for enhancing breast cancer detection. A total 3440 PS-OCT images were intraoperatively acquired from 9 human specimens diagnosed by H&E histology as healthy fibro-adipose tissue (n = 2), stroma or invasive ductal carcinoma (IDC, n 5). standard OCT-based metric (coefficient variation (CV)) PS-OCT-based metrics sensitive to biological birefringence (i.e.,...
Early growth response 1 (EGR1) is a crucial transcription factor composed of zinc finger structures, inhibitory and activating regulatory regions. We identified the biological effect molecular mechanisms EGR1 in breast cancer (BC).
With the latest advancements in optical bioimaging, rich structural and functional information has been generated from biological samples, which calls for capable computational tools to identify patterns uncover relationships between characteristics various biomedical conditions. Constrained by existing knowledge of novel signals obtained those bioimaging techniques, precise accurate ground truth annotations can be difficult obtain. Here we present a weakly supervised deep learning framework...
Histone demethylases, enzymes responsible for removing methyl groups from histone proteins, have emerged as critical players in regulating gene expression and chromatin dynamics, thereby influencing various cellular processes. LSD2 LSD1 attracted considerable interest among these demethylases because of their associations with cancer. However, while has received significant attention, not been recognized to the same extent. In this study, we conduct a comprehensive comparison between LSD1,...
Breast-conserving surgery is a frequent option for women with stage I and II breast cancer, radiation treatment, can be as effective mastectomy. However, adequate margin detection remains challenge, too often additional surgeries are required. Optical coherence tomography (OCT) provides potential method real-time, high-resolution imaging of tissue during surgery. Intra-operative OCT excised tissues has been previously demonstrated by several groups. In this study, novel handheld surgical...
Histone demethylases, enzymes responsible for removing methyl groups from histone proteins, have emerged as critical players in regulating gene expression and chromatin dynamics, thereby influencing various cellular processes. LSD2 LSD1 attracted considerable interest among these demethylases because of their associations with cancer. However, while has received significant attention, not been recognized to the same extent. In this study, we conduct a comprehensive comparison between LSD1,...
Abstract With the latest advancements in optical bioimaging, rich structural and functional information has been generated from biological samples, which calls for capable computational tools to identify patterns uncover relationships between characteristics various biomedical conditions. Constrained by existing knowledge of novel signals obtained those bioimaging techniques, precise accurate ground truth annotations can be difficult obtain. Here we present a weakly supervised Deep Learning...
Techniques have been developed to localize sentinel lymph nodes during cancer surgery and for post-operative histology. Intraoperative OCT, however, uniquely offers microscopic label-free in vivo assessment of metastatic disease.