A5000826278- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Hippo pathway signaling and YAP/TAZ
- Plant and animal studies
- Insect symbiosis and bacterial influences
- Animal Behavior and Reproduction
- Developmental Biology and Gene Regulation
- Infectious Diseases and Tuberculosis
- Systemic Lupus Erythematosus Research
- Cerebrospinal fluid and hydrocephalus
- Cell death mechanisms and regulation
- Head and Neck Surgical Oncology
- Invertebrate Immune Response Mechanisms
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Peripheral Neuropathies and Disorders
- Intracranial Aneurysms: Treatment and Complications
- Genomics and Phylogenetic Studies
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Alcoholism and Thiamine Deficiency
- Diagnosis and treatment of tuberculosis
- Nitric Oxide and Endothelin Effects
National Institute of Advanced Industrial Science and Technology
2019-2025
The Open University of Japan
2019-2023
Waseda University
2019
The University of Tokyo
2009-2016
University of Lausanne
2015
Keio University
1983-2000
Kanazawa University
2000
Saiseikai Central Hospital
1999
Takeda (Japan)
1999
Kawasaki Municipal Hospital
1989-1991
Social insects frequently engage in oral fluid exchange – trophallaxis between adults, and adults larvae. Although is widely considered a food-sharing mechanism, we hypothesized that endogenous components of this might underlie novel means chemical communication colony members. Through protein small-molecule mass spectrometry RNA sequencing, found trophallactic the ant Camponotus floridanus contains set specific digestion- non-digestion related proteins, as well hydrocarbons, microRNAs, key...
We investigated the clinical and pathologic characteristics of stroke in 234 patients with systemic lupus erythematosus. Thirteen (5.6%) developed cerebrovascular disease. Cerebral infarction was noted eight, cerebral hemorrhage two, subarachnoid three. In seven (54%) these 13 patients, occurred less than or equal to 5 years after erythematosus diagnosed. Among predisposing risk factors for stroke, hypertension most important. Lupus anticoagulant detected three (38%) anticardiolipin antibody...
A patient with clinical features of idiopathic normal pressure hydrocephalus, who responded dramatically to shunting, was found a necropsy have severe hypertensive and arteriosclerotic vasculopathy multiple lacunar infarcts. There no pathological evidence thickened leptomeninges, fibrosis the arachnoid villi, or Alzheimer9s disease. An abnormal absorption mechanism demonstrated cisternography by an increase in concentration homovanillic acid cerebrospinal fluid. It is suggested that vascular...
Caspase is best known as an enzyme involved in programmed cell death, which conserved among multicellular organisms. In addition to its role caspase emerging indispensable a wide range of cellular functions, have recently been termed caspase-dependent nonlethal processes (CDPs). this study, we examined the involvement death signaling tissue-size determination using Drosophila wing model. We found that executioner caspases Dcp-1 and Decay, but not Drice, promoted growth independently...
The caspases comprise a family of cysteine proteases that function in various cellular processes, including apoptosis. However, how the balance is struck between caspases' role cell death and their nonapoptotic functions unclear. To address this issue, we monitored protein turnover an endogenous caspase inhibitor, Drosophila IAP1 (DIAP1). DIAP1 E3 ubiquitin ligase promotes ubiquitination thereby prevents activation. For study, developed fluorescent probe to monitor external sensory organ...
In metazoan development, the precise mechanisms that regulate completion of morphogenesis according to a developmental timetable remain elusive. The Drosophila male terminalia is an asymmetric looping organ; internal genitalia (spermiduct) loops dextrally around hindgut. Mutants for apoptotic signaling have orientation defect their terminalia, indicating apoptosis contributes morphogenesis. However, physiological roles in been unclear. Here, we show role organogenesis using time-lapse...
Significance Inotocin, the oxytocin/vasopressin-like peptide, is widely conserved in arthropods; however, little known about its molecular function. Here, we show that, ants, expression levels of inotocin and receptor are correlated with age workers their behavior. We also demonstrate that signaling involved desiccation resistance by regulating synthesis cuticular hydrocarbons. propose up-regulation as switch tasks from nursing to foraging a key physiological adaption survive drier...
Polyrhachis lamellidens is a temporary socially parasitic ant. The newly mated P. queen takes over colony of several Camponotus ant species and uses the labor host workers in early stages social parasitism. To facilitate genomic resources for these species, we assembled annotated chromosomal genome using 10× Genomics linked-read Hi-C sequencing, draft its host, japonicus, long-read sequencing with Revio system. assembly 214.1 Mb, 95.5% BUSCO completeness, contains 13,703 protein-coding...
Necrotic cells elicit an inflammatory response through their endogenous factors with damage-associated molecular patterns. Blocking apoptosis in Drosophila wings leads to the necrosis-driven systemic immune by unknown mechanisms. Here, we demonstrate that activation necrotic is mediated commensal gut microbiota. Removing microbiome attenuates hyperactivation of innate signaling IMD pathway necrosis-induced flies. trigger Gluconobacter expansion gut. An isolated sp. strain sufficient for...
Social isolation negatively affects health, induces detrimental behaviors, and shortens lifespan in social species. Little is known about the mechanisms underpinning these effects because model species are typically short-lived non-social. Using colonies of carpenter ant Camponotus fellah, we show that hyperactivity, alters space-use, reduces via changes expression genes with key roles oxidation-reduction an associated accumulation reactive oxygen These physiological localized to fat body...
<b><i>Article abstract</i></b> We analyzed the pathologic features of silent, small hyperintense foci in basal ganglia and thalamus on MRI T2-weighted images (T2WI). Eight were histologically lacunar infarcts (LI), 21 dilated perivascular spaces (DPS). The with smooth margins mostly DPS, whereas those irregular LI (<i>p</i> = 0.018). Most putaminal most thalamic 0.001). mean areas DPS overlapped below 19.6 mm<sup>2</sup>. shape site T2WI are important for differentiating from DPS.
Article abstract The authors report a case of localized hypertrophic mononeuropathy involving the femoral nerve in 20-year-old woman referred because progressive weakness and atrophy left thigh. MRI showed an enlarged biopsies fascicles displayed concentric pattern cells resembling onion bulb. These were positive for epithelial membrane antigen immunostaining had incomplete basal lamina.
Integrative and conjugative elements (ICEs) are widespread mobile DNA in the prokaryotic world. ICEs usually retained within bacterial chromosome, but can be excised transferred from a donor to new recipient cell, even of another species. Horizontal transmission ICEclc, prevalent ICE proteobacteria, only occurs developed specialized transfer competent (tc) cells population. tc become entirely dedicated at cost cell proliferation. The growth impairment is mediated by two ICEclc located genes,...
Social animals, such as primates and some insects, have been shown to exchange symbiotic microbes among individuals through sharing diet or habitats, resulting in increased consistency of microbiota social partners. The ant is a representative insects exhibiting various castes within colony; queens, males, nonreproductive females (so-called workers) show distinct morphologies, physiologies, behaviors but tightly interact with each other the nest. However, how this context affects their gut...
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare multisystem disorder. Although its pathogenesis remains elusive, there evidence that vasculopathy may have an important role.1-3 We report autopsied case of POEMS in which necrotizing vasculitis was identified as salient pathologic feature. A 63-year-old man admitted to the hospital because difficulty walking tingling sensation his legs. On physical examination, edema bilateral legs...
Apoptosis is essential for normal development. Large numbers of cells are eliminated by apoptosis in early neural development and during the formation connections. However, our understanding this life-or-death decision incomplete, because it difficult to identify dying conventional strategies. Live imaging powerful studying apoptosis, can trace a death-fated cell throughout its lifetime. The Drosophila sensory organ convenient system neural-cell selection via lateral inhibition. We recently...
Apoptosis is essential for normal development. Large numbers of cells are eliminated by apoptosis in early neural development and during the formation connections. However, our understanding this life-or-death decision incomplete, because it difficult to identify dying conventional strategies. Live imaging powerful studying apoptosis, can trace a death-fated cell throughout its lifetime. The Drosophila sensory organ convenient system neural-cell selection via lateral inhibition. We recently...