A5057972040- Cardiovascular Disease and Adiposity
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Adipose Tissue and Metabolism
- Trauma Management and Diagnosis
- Cardiac Valve Diseases and Treatments
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Infective Endocarditis Diagnosis and Management
- Pneumothorax, Barotrauma, Emphysema
- Mechanical Circulatory Support Devices
- MicroRNA in disease regulation
- Vascular Procedures and Complications
- MXene and MAX Phase Materials
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Issues in Pregnancy
- Circular RNAs in diseases
- Infectious Aortic and Vascular Conditions
- Adipokines, Inflammation, and Metabolic Diseases
- Peripheral Artery Disease Management
- Advanced Memory and Neural Computing
- Fuel Cells and Related Materials
- Pleural and Pulmonary Diseases
Yale New Haven Hospital
2020-2024
Yale University
2020-2024
University Hospital of Heraklion
2016-2023
University of Crete
2017
Foundation for Research and Technology Hellas
2014
Background Data from the International Registry of Acute Aortic Dissection indicate that guideline criterion 5.5 cm for ascending aortic intervention misses many dissections occurring at smaller dimensions. Furthermore, studies natural behavior have generally treated root and aorta as 1 unit despite embryological, anatomical, functional differences. This study aims to disentangle histories aforementioned segments, allowing define specific criteria segments aorta. Methods Results Diameters...
Pericoronary adipose tissue (PCAT) is a source of microRNAs (miRs) that act as messengers for intercellular communication. We investigated whether the PCAT surrounding significant coronary atherosclerotic lesions shows specific miR expression patterns compared with plaque-free segments. included 49 patients 3-vessel artery disease (CAD) and 19 severe valvular but no CAD, who underwent elective cardiac surgery. The was harvested from two sites: adjacent to lesion miR-133a, miR-21, miR-26b,...
Ascending aortic aneurysms pose a different risk to each patient. We aim provide personalized stratification for such patients based on sex, age, body surface area and aneurysm location (root versus ascending).
Heart failure can be treated with devices that mechanically support the circulation. The improvement of these would benefit many patients, especially those refractory to maximal pharmacological treatment and ineligible for heart transplantation. This study examined whether shape memory alloy (SMA) fibers, which are fibers contract when electric current flows through them relax passively flow is interrupted, wrapped around failing assist in its pumping action. A band SMA was a silicon...
Pneumorachis, or intraspinal air, can be a rare result of blunt thoracic trauma. We report the case 40-year-old man with multiple injuries and pneumorachis associated persistent tachycardia. As factors that increase heart rate were gradually ruled out, air was considered potential culprit. Computed tomography revealed at level, which possibly promoted cardiac arrhythmogenesis. Air may transiently compress preganglionic sympathetic nerves output to heart.
The clinical importance of following up on the ascending aortic diameter lies in fundamental presumption that wall pathology eventually manifests as a change shape. However, describes vessel locally, and 55 mm criterion fails to prevent most dissections. We hypothesized geometric changes across aorta are not necessarily imprinted its diameter; i.e. maximum correlates weakly insignificantly with elongation, surface stretching, engorgement, tortuosity.
We report a subtle-discrete aortic dissection, without bulging of the wall or aneurysm valve pathology periaortic effusion, which resulted in lethal cardiac tamponade to 35-year-old male.
A 52-year-old woman presented with a complex ventricular arrhythmia in an intraoperative context, during kyphoplasty for osteoporotic fracture of lumbar vertebra. The subject showed no indications previous cardiovascular condition.Causes arrhythmias associated the procedure were excluded. Due to her positive family history dilated cardiomyopathy, upcoming thoughts made unmasking asymptomatic cardiomyopathy. Nevertheless, intracardiac cement embolism was diagnosed and, finally, patient...
The aneurysms of the innominate artery represent a rare form aneurysmal disease. Management in an early elective basis is recommended due to risk stroke and rupture. Treatment options include open surgery, which gold standard, endovascular repair. We describe debranching-first technique proximal arch replacement for huge aneurysm discuss surgical strategy cannulation, perfusion organ protection.
Pericoronary adipose tissue (PCAT) plays a key role in the pathogenesis of atherosclerosis. PCAT is source microRNAs (miRs) that acts as messengers for intercellular communication. In this study, we investigated whether surrounding coronary occlusive atherosclerotic lesions shows specific miR expression patterns compared to plaque-free segments. We evaluated miRs are known be implicated pathophysiology atherosclerosis.We included 49 patients (38 men, age 65±9 years) with 3-vessel artery...
Pericoronary adipose tissue (PCAT) regulates arterial homeostasis, is considered to act in paracrine manner, and plays a role the pathogenesis of atherosclerosis. PCAT may be source microRNAs (miRs) that target other tissues as messengers for intercellular communication. In this study, we investigated whether surrounding coronary occlusive atherosclerotic lesions shows specific miRs expression patterns patients with diabetes type 2 compared non-diabetic patients.We enrolled 46 (30 men, aged...
A 52-year-old woman presented with malignant ventricular arrthythmogenesis intraoperatively during kyphoplasty for an osteoporotic fracture of a lumbar vertebra. No previous cardiovascular condition was known. Causes arrhythmogenesis associated the procedure were excluded. Due to her positive family history dilated cardiomyopathy, upcoming thoughts made unmasking asymptomatic cardiomyopathy. Nevertheless, intracardiac cement embolism diagnosed and, finally, patient underwent open heart...
Abstract Background Pericoronary adipose tissue (PCAT) regulates arterial homeostasis, is considered to act in paracrine manner, and plays a role the pathogenesis of atherosclerosis. The nuclear receptor Peroxisome Proliferator-Activated gamma (PPARγ) key regulator adipogenesis, alterations its function are associated with different pathological processes related metabolic syndrome inflammatory response. Purpose To investigate whether PCAT surrounding coronary occlusive atherosclerotic...
Abstract Background Pericoronary adipose tissue (PCAT) plays a key role in the pathogenesis of atherosclerosis. PCAT is source microRNAs (miRs) that acts as messengers for intercellular communication. In this study, we investigated whether surrounding coronary occlusive atherosclerotic lesions shows specific miR expression patterns compared to plaque-free segments. Purpose To evaluate miRs are known be implicated pathophysiology Methods We included 49 patients (38 men, age 65±9 years) with...