A5052086076- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Infectious Aortic and Vascular Conditions
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- COVID-19 Clinical Research Studies
- Cardiac and Coronary Surgery Techniques
- Trauma and Emergency Care Studies
- Congenital Heart Disease Studies
- Tracheal and airway disorders
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Coronary Artery Anomalies
- Health and Medical Research Impacts
- Kawasaki Disease and Coronary Complications
- Healthcare Systems and Challenges
- Cardiac Arrest and Resuscitation
- Ultrasound in Clinical Applications
- Acute Ischemic Stroke Management
- Cardiac tumors and thrombi
- Head and Neck Anomalies
St Bartholomew's Hospital
2020-2025
William Harvey Research Institute
2023-2024
Master's College
2023
Queen Mary University of London
2023
Barts Health NHS Trust
2022
University Hospital of Wales
2014-2021
Leicester General Hospital
2021
Morriston Hospital
2016-2017
Background Acute Type A aortic dissection (TAAD) is a life-threatening condition that carries significant mortality and morbidity; proportion of the survivors might require further procedures in mid-/long-term follow-up. Quality life (QoL) after TAAD not well studied. Aortic Dissection Surgery (QUADS) first multicentre study to assess QoL surgically treated TAAD. Methods tailored questionnaire for was designed with patient public involvement. Patients who underwent surgery from 2018 2022...
Abstract The management of thoraco-abdominal aortic aneurysms (TAAA) remains challenging particularly in patients considered unsuitable for conventional endovascular due to unfavourable anatomy or unfit traditional open surgical approaches comorbidities. In response these limitations, a novel hybrid prosthesis has emerged as an alternative designed reduce invasiveness, avoid cross-clamping and extracorporeal circulation. Thoracoflo® (Terumo Aortic, Glasgow, UK), been developed bridge the gap...
Abstract The coronavirus 2019 (COVID-19) pandemic has disrupted patient care across the NHS. Following suspension of elective surgery, priority was placed in providing urgent and emergency surgery for patients with no alternative treatment. We aim to assess outcomes undergoing cardiac who have COVID-19 infection diagnosed early postoperative period. identified 9 developed following surgery. These had a significant length hospital stay extremely poor mortality 44%. In conclusion, outcome...
The novel coronavirus, now termed SARS-CoV-2, has caused a significant global impact in the space of 4 months. Almost all elective cardiac surgical operations have been postponed order to reduce transmission and allocate resources adequately. Urgent emergency surgery is still taking place during pandemic. decision operate urgent patients with active/recent COVID-19 infection difficult make, particularly as it an unknown disease entity setting emergent surgery. We present case series three...
To analyse operative outcomes and mid-term results following isolated aortic valve replacement (AVR) in patients with low-flow low-gradient severe stenosis (LFLG AS) compared normal flow high-gradient (NFHG AS). A retrospective analysis of data for all AVRs performed AS at our centre the last 17 years ( n = 846). Two groups were identified: LFLG 198, 23%) [subdivided into: True 66, 33%) paradoxical 132, 67%)] NFHG 648, 77%). Follow-up was done by clinical visits telephone interviews. The...
During the worldwide COVID-19 pandemic, elective cardiac surgery was suspended to provide ICU beds for patients and those requiring urgent surgery. The aim of this study is assess effect pandemic on outcomes awaiting surgery.A multi-centre prospective cohort study.The adult waiting list as 1 March 2020 across seven UK surgical centres.Patients centres.Primary outcome surgery, percutaneous therapy or death at one year.Data were collected prospectively centres. Primary year. Demographic data...
Abstract Objectives Aortic pathologies often present with elevated inflammatory biomarkers due to the nature of disease. Open aortic surgery causes significant trauma body mandatory ischemic periods, long cardiopulmonary bypass times and polytransfusion. We aim determine postoperative trends on inflammation for different type in segments aorta. Methods Retrospective review prospectively collected data 193 consecutive patients who underwent our centre between 2017 2021, grouped according...
Open surgical repair remains the gold standard for treatment of thoracoabdominal aortic aneurysm (TAAA). Surgery aims to replace whole length diseased distal aorta while protecting spinal cord and visceral organs limit ischemia-related complications. The substantial associated risks, including death, paraplegia, renal failure requiring permanent dialysis, respiratory complications leading prolonged intensive care unit stay, still outweigh natural history TAAA with conservative treatment.We...
A significant restructuring of the healthcare services has taken place since declaration coronavirus disease 2019 (COVID-19) pandemic, with elective surgery put on hold to concentrate intensive care resources treat COVID-19 as well protect patients who are waiting for relatively low risk from exposure potentially infected hospital environment.Multicentre study, 19 participating centers, define impact pandemic provision aortovascular and patients' outcomes after having adapted thresholds...
Objective The coronavirus disease 2019 (COVID-19) pandemic has restructured the healthcare systems, prioritizing resources to treat COVID-19 patients. aim of this study was establish if patients affected by acute aortic syndrome (AAS) had unrestricted access emergency treatment and evaluate outcome these during peak pandemic. Methods This is a retrospective analysis prospectively collected data between March June 2020 from 19 participating cardiac surgery centers in United Kingdom. Results...
Objective The coronavirus disease (COVID-19) increases the respiratory complications and carries a higher mortality in immediate postoperative period. aim of this study was to analyze outcomes patients with type A acute aortic syndromes (AAS) diagnosed COVID-19 perioperative Methods Retrospective analysis prospectively collected data between March August 2020 from 20 participating cardiac surgery centers United Kingdom. Results Among 122 who underwent emergency surgical repair for AAS at...
Abstract Retrograde type A aortic dissection (RTAAD) can be spontaneous or secondary to the instrumentation of descending and thoraco-abdominal aorta. It has anatomical differences compared antegrade that impact management prognosis. Treatment is not standardized. We report our approach RTAAD in institution between 2018 2022 (n = 15). The mean age was 60.1 years 93% were male. Aortic valve, coronary arteries supra-aortic trunks spared by 80% cases; distal extension iliacs common lower limb...
The coronavirus disease 2019 (COVID-19) pandemic has posed challenges to health care services across the world. There been a significant restructuring of resources protect for patients with COVID-19-related illness and maintain emergency urgent medical surgical activity. This study assessed access treatment, logistical challenges, outcomes acute aortic syndrome during early months COVID-19 in United Kingdom.This was multicenter study, from March 1 May 20, 2020 that included 19 cardiac...
Objective Exploratory analysis to conceptualize and evaluate the potential cost-effectiveness economic drivers of using a novel tissue valve compared with mechanical heart valves for surgical aortic replacement (SAVR) in people aged 55–64 65+ stenosis (AS) from National Health Service (NHS) UK perspective.Methods A decision-analytic model was developed partitioned survival model. Parameter inputs were obtained published literature. Deterministic probabilistic sensitivity analyses (DSA PSA)...
We present a patient with large thymoma on the right thoracic cavity developing from visceral pleura. This is rare location for this tumour, and only few had been reported to date in literature.
To analyze operative outcomes and mid-term results after isolated aortic valve replacement (AVR) in low-flow, low-gradient stenosis (LFLG AS) by comparing the 2 subcategories (classic [CLFLG] paradoxical [PLFLG]).This was a retrospective analysis of prospectively collected data for all AVR LFLG AS performed our center during last 13 years (n = 198; CLFLG AS, n 66, 33% PLFLG 132, 67%). Median follow-up 3.7 ± 3.3 years.Preoperative mean gradient 30.2 8.8 mm Hg group 31.4. 7.0 mmHg (P .001)....
In the United Kingdom, coronavirus disease 2019 (COVID-19) pandemic has led to cessation of elective surgery. However, there remains a need provide urgent and emergency cardiac thoracic surgery as well continue time-critical cancer This study describes our early experience implementing protocol safely deliver major in midst pandemic.Data on all patients undergoing cardiothoracic at single tertiary referral center London were prospectively collated during first 7 weeks lockdown Kingdom. A...