A5083795576- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- COVID-19 and healthcare impacts
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Cardiac tumors and thrombi
- Clinical practice guidelines implementation
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac and Coronary Surgery Techniques
- Aortic aneurysm repair treatments
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Trauma and Emergency Care Studies
- Cardiovascular Issues in Pregnancy
- Coronary Interventions and Diagnostics
- Healthcare Systems and Challenges
- Infective Endocarditis Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Infectious Aortic and Vascular Conditions
- Health and Medical Research Impacts
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Atrial Fibrillation Management and Outcomes
St Bartholomew's Hospital
2017-2024
British Heart Foundation
2023
Queen Mary University of London
2023
William Harvey Research Institute
2023
St George's Hospital
2013-2020
St George's Hospital
2009-2020
Mount Sinai Medical Center
2018
St Thomas' Hospital
2017
Guy's and St Thomas' NHS Foundation Trust
2016
University of London
2014
Abstract The PAX8/PPARγ (PPFP) fusion-oncogene is moderately specific for follicular thyroid carcinomas (FTC). It remains unknown whether this can be translated into improved diagnosis, classification, or outcome prediction. We studied a cohort of well-characterized adenomas (FA), FTC, and Hürthle cell (HCC) from patients with complete clinical follow-up, to determine PPARγ immunohistochemistry (as surrogate expression) helps distinguish FA FTC assess its diagnostic accuracy as an adjunct...
Abstract The coronavirus 2019 (COVID-19) pandemic has disrupted patient care across the NHS. Following suspension of elective surgery, priority was placed in providing urgent and emergency surgery for patients with no alternative treatment. We aim to assess outcomes undergoing cardiac who have COVID-19 infection diagnosed early postoperative period. identified 9 developed following surgery. These had a significant length hospital stay extremely poor mortality 44%. In conclusion, outcome...
To present a detailed description of aortic arch morphology in patients with aneurysm and dissection undergoing thoracic endovascular repair (TEVAR).Morphological assessment the was performed consecutive series TEVAR between November 2003 April 2009. In absence standardized reporting criteria, any patient requiring overstenting left subclavian artery (LSA) considered to have pathology arch. all, 49 (31 men; mean age 70 years, range 43-86) analyzed (25 aneurysms 24 dissections). The proximal...
Minimally invasive aortic valve replacement (Mini-AVR) is a technically advanced procedure. However, it results in equivalent operative mortality, less bleeding and reduced intensive care/hospital stay when compared with conventional AVR. Our aim was to assess the impact of trainee performance on short-term outcomes patients undergoing elective urgent Mini-AVR where significant proportion were performed by trainees. All non-emergency, urgent, isolated between September 2005 December 2012...
During the worldwide COVID-19 pandemic, elective cardiac surgery was suspended to provide ICU beds for patients and those requiring urgent surgery. The aim of this study is assess effect pandemic on outcomes awaiting surgery.A multi-centre prospective cohort study.The adult waiting list as 1 March 2020 across seven UK surgical centres.Patients centres.Primary outcome surgery, percutaneous therapy or death at one year.Data were collected prospectively centres. Primary year. Demographic data...
Abstract Objectives Aortic pathologies often present with elevated inflammatory biomarkers due to the nature of disease. Open aortic surgery causes significant trauma body mandatory ischemic periods, long cardiopulmonary bypass times and polytransfusion. We aim determine postoperative trends on inflammation for different type in segments aorta. Methods Retrospective review prospectively collected data 193 consecutive patients who underwent our centre between 2017 2021, grouped according...
The clinical outcomes of patients discharged after prolonged postoperative intensive care unit (ICU) stay following cardiac surgery are unclear. aim this study was to assess survival and functional status in whose ICU exceeded 5 or 10 days a tertiary surgical unit.Patients undergoing adult between October 2008 2010 who stayed an for 5-10 (Group A) >10 B) were studied. Demographics, operative details data prospectively collected. follow-up all performed by telephone questionnaire. Functional...
BackgroundInhomogeneity of ventricular contraction is associated with sudden cardiac death, but the underlying mechanisms are unclear. Alterations in impact electrophysiological parameters through mechanoelectric feedback. This has been shown to promote arrhythmias experimental studies, its effect vivo human heart unclear.ObjectiveThe purpose this study was quantify regional myocardial deformation provoked by a increase loading (aortic occlusion) on electrophysiology.MethodsIn 10 patients...
In the United Kingdom, coronavirus disease 2019 (COVID-19) pandemic has led to cessation of elective surgery. However, there remains a need provide urgent and emergency cardiac thoracic surgery as well continue time-critical cancer This study describes our early experience implementing protocol safely deliver major in midst pandemic.Data on all patients undergoing cardiothoracic at single tertiary referral center London were prospectively collated during first 7 weeks lockdown Kingdom. A...
Guidelines recommend concomitant atrial fibrillation (AF) ablation during cardiac surgery to restore normal sinus rhythm (NSR). The study determines, what extent patients with AF undergoing at our institution received a procedure, these procedures entailed, and short-term outcomes.A retrospective of 2,984 over 18 months. Patients who were in preoperative identified those underwent procedure (Group 1) compared did not 2).Three hundred thirteen (10.5%) had pre-operative AF; paroxysmal (19.5%),...
Abstract Background Errors in the handover of patients from cardiothoracic operating room (OR) to intensive care unit (ICU) can compromise patient safety. We have previously shown that standardising operation names and educating junior medical staff enhanced accuracy note titles. Aim This study aimed assess name consistency OR ICU notes, evaluating impact standardisation education. Method A prospective cardiac surgery at St. Bartholomew's Hospital was undertaken November 29 December 10,...
Abstract Background Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiac disease characterised by myocardial hypertrophy in absence of alternative causes. Most HCM patients have left ventricular outflow tract (LVOT) obstruction due to systolic anterior motion mitral valve (MV) leaflet and interventricular septum thickening. Septal myectomy coupled with MV repair or replacement can resolve this obstruction. Case We present a 42-year-old female referred for septal...
<title>Abstract</title> Rapid growth of a left atrial myxoma was demonstrated in patient who showed no echocardiographic evidence the tumour when she admitted for an fibrillation catheter ablation. Eighteen months later, presented with temporary visual disturbance, and transthoracic echocardiography 35 x 25 20 mm myxoma. This excised en-bloc histopathology confirmed diagnosis benign